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The Groucho ortholog UNC 37 interacts with the short Groucho like protein LSY 22 to control developmental decisions in C elegans

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Academic year: 2020

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Figure

Fig. 1. Left/right asymmetry of the ASE neurons is controlled bya complex network of regulatory factors, including (downstream gcy-5::mCherryexpressed in ASER (the ‘two ASEL’ phenotype)
Fig. 2. Molecular identity of lsy-22Variants were considered as background if they were also found inother WGS datasets from the laboratory (see Materials and methods).**, 1/7 was found to be a heterozygous variant
Fig. 3. lsy-22 and unc-37 control similardevelopmental processes. (A)lsy-22 synergizes with
Fig. 4. LSY-22 physically interacts with UNC-37. (hybrid assay with UNC-37 and LSY-22 fused to the GAL4-activatingdomain (AD) or DNA-binding domain (BD) shows interaction of thesetwo proteins

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