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Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320

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Academic year: 2020

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Figure

Figure 1. Functional inhibition of bone marrow mesenchymal stromal cells in chronic myelogenous leukemia
Figure 2. Leukemia cell-secreted exosomes are efficiently taken up by BMMSC. (A) Transmission electron microscopy images of exosomes derived from K562 cells
Figure 3. Leukemia cell-secreted exosomes inhibit BMMSC function in vitrodays, followed by ALP staining after 14 days or by alizarin red staining after 28 days
Figure 4. Specific repertoires of miRNAs are sorted into leukemia exosomes. (A) Deep sequence data visualization by scatter plot comparing miRNAs in K562 cells and derived exosomes
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