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<p>Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats</p>

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Academic year: 2020

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Figure 1 Continuous intrathecal infusion of melatonin type-2 (MT-2) agonist IIK-7 attenuated the development of nerve-transection-induced neuropathic pain (n=6)
Figure 2 Pre-treatment of IIK-7 antagonist 4-p 20 mins prior to IIK-7 administration did not result in significant blockade of IIK-7-induced anti-nociception in nerve-transection-induced neuropathic pain (n=6)
Figure 4 IIK-7 reduces ROS production induced by TLR1/2 agonist PAM3CSK4. Thebone-derived macrophages are either untreated (Blank) or treated with IIK-7 (25 ng) orstimulated with triacylated bacterial lipopeptide PAM3CSK4 (5 μg/mL) or pre-incubatedIIK-7 fo
Figure 6 IIK-7 treatment reduces PSNT-induced iNOS expression in rat spinalquantifor the vehicle-injected group
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