1
1. The extracellular fluid isA. 80 % interstitial fluid and 20 % plasma B. 60 % interstitial fluid and 40 % plasma C. 50 % interstitial fluid and 50 % plasma D. None of the above
2. The fluid mosaic model is found in A. Amino acid forming proteins B. Nucleic acids forming DNA C. Lipid bilayer of plasma membrane
D. Arrangement of collagen fibers in cellular matrix
3. Which type of membrane junction is
responsible for holding adjacent cells firmly together in areas that are subjected to considerable stretching such as skin
A. Tight junction B. Desmosomes C. Gap junctions D. None of the above
4. The type of membrane junction which plays an important role in electrical conductivity of heart cells and smooth muscle is
A. Tight jucntion B. Gap junction C. Desosomes D. Pace maker’s
5. Mitochondria are the site of all the following except
A. Oxidative phosphorylation B. Kreb’s cycle
C. Glycogen synthesis D. Glycogen breakdown
6. The following organelle is surrounded by single layer
A. Mitochondria
B. Endoplasmic reticulum C. Peroxisomes
D. Filaments
7. Golgi bodies are responsible for A. Synthesis of polypeptides B. Formation of glycoproteins only
C. Modification and sorting of glycoproteins D. Lipid and steriod synthesis.
8. Which cell organelles contain DNA? A. Mitochondria
B. Golgi body
C. ER D. Centriole
9. A gene in a DNA is responsible for coding of A. An aminoacids
B. A polypeptide C. A part of polypeptide D. None of the above
10. The code word of which proteins is also as initiation code for proteins
A. Leucine B. Isoleucine C. Methionic D. lyrine
11. The m-RNA formed by transcription of DNA to RNA are 75-90 % shorter than originally transcribed because
A. The DNA contains 76-90 % of nonsense condons which are deleted by m-RNA processing.
B. Only relevant codons are transcribed in m-RNA
C. The proteins formation requires only small and shorter m-RNA for translation. For movement through nucleus
D. The initial codon and terminal codons are deleted making m-RNA shorter.
12. The mitotic apparatus consists of
A. Spindle fibres, centromere and a single chromatid
B. Spindle fibres, centromeres, a single chromatid, centriole.
C. Centriole, spindle fibre. D. None of the above 13. In primary active transport
A. The addition of Na+on the higher Na+ concentration will cause movement of molecules into the cell
B. The covalent bonding will cause informational modulation of carrier protein.
C. The use of ATPase enzymes causes high solubility of substrate in lipid bilayer and hence its transport in the cell.
D. The concentration gradient of Na+ plays most important role.
14. In secondary active transport the movement of Na+ is
2
A. From intracellular high concentration toextracellular low concentraion
B. From intracellular low concentration to extracellular high concentraion
C. Not to be considered
D. Not possible in any direction. 15. A hypertonic solution contains
A. More than 300mmoles/L of non diffusible ions and variable diffusible ion concentration B. The total ion concentration should be above
300mmoles/L
C. A diffusible ion concentration above 300 mmoles/L
D. 20 moles of solute/litre. 16. Osmotic pressure
A. It is a pressure of a solution which causes osmotic flow
B. It is the pressure that must be applied to the solution to prevent osmotic flow.
C. It is directly proportional to the molecular weight of the solute
D. It arises due to complete impermeability to solute and water of a membrane
17. Coenzyme A is reponsible for’ A. Transmethylation
B. Transacetylation C. -2H-transport D. Transfer of folic acid.
18. The hydrolysis of ATP-ADP releases A. 2Kcal/mol
B. 7Kcal/mol C. 38Kcal/mol D. 42Kcal/mol
19. Cell shape and motility is provided by A. Microfilaments
B. Microtubules C. Golgi apparatus D. Nucleus
20. Protein synthesis takes place in A. Ribosome
B. Rough endoplasmic reticulum C. Nucleus
D. Golgi bodies
21. Which of the following molecules can easily penetrate a biological membrane:
A. Small sized lipid soluble and unionised molecules
B. Highly charged, large sized and lipid non soluble
C. Small sized, ionised and lipid soluble molecules
D. Large sized lipid non-soluble
22. The osmolarity of fluid A is twice that of B (A is hypertonic with respect to B) they are seperated by a semipermeable membrane the water will most.
A. From A towards B B. From B towards A C. No movement will occurs D. Can move in either direction
23. All of the following are true of active transport except
A. Active transport of inorganic ions required B. Certain drugs can block this transport system
energy and is unidirectional.
C. Substances are transported from low to high concentration by utilising energy against concentration gradient
D. Glucose is usually actively transported into the muslce
24. The largest fraction of the total body fluid is A. Extracellular
B. Intracellular fluid C. Plasma
D. Whole blood
25. Which of the following proteins is mainly responsible for colloidal osmotic pressure (oncotic pressure)
A. Albumin B. Fibrinogen C. Alpha globulin D. Beta globulin
26. During formation of oedema, ie., movement of
water from vascular into extra-vascular
space,plasma colloid osmotic pressue acts in the same direction as
A. Capillary pressure B. Arteriole pressure C. Tissue pressure
D. Tissue osmotic pressure
27. Which of the following tries to retain fluid within vascular compartment?
3
A. Increased capillary pressure and venouspressure
B. Tissue pressure and colloidal oncotic pressure of plasma
C. Increased permeability and colloidal oncotic pressure of plasma
D. All of the above 28. Oedema is formed when
A. Tissue osmotic pressure in lower than that of plasma colloidal osmotic pressure
B. Increased permeability of capillaries with increased blood pressure in capillaries
C. The blood collidal osmotic pressure is reduced with the increase in plasma collidal osmotic pressure
D. None of the above
29. Which of the following is associated with sensation of cold?
A. Pacinaian corpusles B. End organs of Ruffini’s C. Naked nerve ending D. Meissener corpuscles
30. Which organ has maximum flow of blood in ms/100g per min?
A. Skin B. Kidney C. Brain D. Heart
31. In myelinated nerve, the depolarisation wavejumps from one node of ranvier to the next. This form of conduction is which results inhigher velocity of transmission is called as A. Pandromic conduction
B. Saltatory conduction C. Orthodromic conduction D. Antichromic conduction 32. A motor unit is made up of
A. Flexor muscle and an extensor muscle
B. A single skeletal muscle and all the motor neurons that supply it
C. A single motor neutron and all the muscle fibreas it innervates
D. All the motor neurons in which responses are observed after maximal stimulation of a single sensory nerve
33. The strength of contraction of skeletal muscle does not depend on
A. Total number of motor units stimulated B. Duration of action potential in the motor nerve C. Frequency of action potential in each motor
nerve
D. Amount of summation in each motor unit 34. All of the following are ture about tension
receptors except
A. Muscle spindles have high threshold
compared to tendon organs
B. Muscle spindles are oriented parallel to long axis of extrafusal muscle fibres
C. Muscle spindle responds only to passive stretch
D. Tendon organ responds both to passive stretch and contraction
35. Voluntary contraction of skeletal muscle is A. Tetanic in nature
B. Not always tetanic in nature C. Never tetanic in nature
D. Not related to tetanic response
36. A unique character of smooth muscle is
A. It can sustain contraction for prolonged periods B. Des not require calcium for contraction
C. ATP is not required for contraction D. All of the above
37. Which of the following receptors are correctly matched for sensation
A. Touch meissener’s corpuscles B. Pressure – pacinian corpuscles C. Heat – krauases bulb
D. All of the above
38. If the blood colloidal osmotic pressure decreases, fluid will shift from
A. Intra cellular spaces to the inerstitial space (extravascular space)
B. Blood (vacular compartment) to interstitial space (extravascular compartment
C. Extracellular space to intracellular space (interstitial space to blood)
D. None of the above
39. Which organ has maximum weight next to skin A. Liver
B. Kidney C. Brain D. Heart
4
40. The number of sodium channels per µm2 ofmembrane in myelinated nerve fiber is maximum at the
A. Axon hillock B. Axon terminal C. Node of Ranvier D. Cell body
41. Oxygen affinity decreases in A. Hypoxia
B. Hypothermia C. HbF
D. Increased Ph
42. Increase in partial pressure of CO2 leading to
release of oxygen to the tissues is A. Haldane effect
B. Bohr effect C. Bruer effect D. Hamburger effect
43. Vital capacity is a measure of A. Tidal volume
B. Inspiratory reserve volume plus expiratory volume.
C. Tidal volume plus inspiratory reserve volume plus expiratory reserve volume
D. Expiratory reserve volume plus reserve volume
44. Which of the following statements about pulmonary surfactant is false
A. It is secreted by type II pneumocytes B. It contains lecithin and sphinogomyelin C. It increases surface tension
D. It prevents collapse of smaller alveoli
45. Which of the following does not stimulate alveolar hyperventilation
A. Hypoxia B. Hypercapnia C. Acidosis
D. Stretching airways
46. At high altitudes the following changes take place except
A. Increases in respiratory rate B. Increases in depthof respiration
C. Increases in O2 carrying capacity of blood.
D. Increases in partial pressure of CO2
47. The most common form of hypoxia is A. Hypoxic
B. Stagnant C. Anaemic D. Histotoxic
48. Ventilation perfusion ratio is maximum in A. Base of lung
B. Apex of lung
C. Posterior lobe of lung D. Middle lobe of lung
49. Kussmaul’s respiration occurs in response to A. Decrease in pH of blood
B. Increase in pH of blood
C. Obstructive pulmonary disease D. Carbon monoxide poisoning
50. Shift of the oxygen dissociation curve to right is caused by the following factors EXCEPT A. Increased 2, 3, BPG
B. Increased temperature
C. Increased concentration of carbon – di – oxide D. Increased concentration of oxygen
