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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation

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Figure 1: Regulation of the cell cycle by cyclin-CDK complexes Each stage of the cell cycle is tightly regulated by a specific CDK molecule complexed with its partnering cyclin
Figure 2: The enzyme cascade resulting in substrate ubiquitylation (Dikic et al., 2009) (A) The activation of ubiquitin monomers and their transfer to the substrate
Figure 3: Pathway of a 26S proteasome substrate (Hochstrasser, 2009) (A) Substrates are marked for degradation by poly-ubiquitylation
Figure 4: The APC/C and SCF complexes regulate each other during different stages of the cell cycle (Fasanaro et al., 2010) (A) During the G phase, APC/CCdh1 regulates SCF
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ALTERNATIVE FUNCTIONS OF CIZ Discussion Identifying a possible E3 ligase responsible for Ciz1 ubiquitylation: APC/C Cdh Determining phosphorylation rate profiles of Ciz1-N471 by cyclin A-CDK2 at T293 and S CDK-mediated phosphorylation of Ciz Ciz1 is a target of the ubiquitin proteasome system

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