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Compound Libraries

2015

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Customize Your Library

You can customize your library by selecting compounds of interest.

Build the right library for your research endeavors by choosing from compounds in all of our available libraries. You could select:

Please contact us at [email protected] to customize your library. Specific

Compounds

Quantities Plate map Concentration Format

(Dry/solid or DMSO solution)

Nat Med, 2014, 20(8): 954-60 Nat Cell Biol, 2015, 17(1): 57-67 Nat Prod Rep, 2014, 31(6): 718-29 Cancer Res, 2014, 74: 1702

Oncogene, 2014, 10.1038/onc.2014.351 Oncotarget, 2014, 5(15): 6512-25 Mol Cancer Ther, 2014, 13(2): 353-63 ACS Chem Biol, 2014, 9(5): 1160-71 Mol Cancer Res, 2014, 12(5): 703-13

Antimicrob Agents Chemother, 2014, 58(8): 4875-84 ...

Product Citations

Contents

L1700 Bioactive Compound Library...1

L1200 Kinase Inhibitor Library... 2

L1300 FDA-approved Drug Library...3

L1100 Inhibitor Library... 4

L1900 Epigenetics Compound Library...5

L1400 Natural Product Library...5

L3500 Target Selective Inhibitor Library... 6

L2200 GPCR Compound Library...7

L3000 Anti-cancer Compound Library... 8

L1800 Tyrosine Kinase Inhibitor Library...

.

...9

L2100 Stem Cell Signaling Compound Library...9

L2300 Cambridge Cancer Compound Library... 10

L2400 Pfizer Licensed Compound Library...11

L2600 Autophagy Compound Library... 12

L2700 Ion Channel Ligand Library...12

L2800 PI3K/Akt Inhibitor Library...13

L3300 Apoptosis Compound Library...13

L3400 MAPK Inhibitor Library...14

L2500 Protease Inhibitor Library...14

L3100 Anti-infection Compound Library...15

L2900 Anti-diabetic Compound Library...15

0

5 10 15 20 25 30 35 40 45 50 0 5 10 15 20 25 30 35 40 45 50

Compound Libraries (96-Well)

Compound Library Advantages

Compound Libraries are ready-to-use chemical libraries used for drug discovery, lab drug screening, drug target identification, and other pharmaceutical-related applications.

The libraries consist of a unique and diverse collection of over 2,100 small molecules with validated biological and pharmacological activities.

Safety and effectiveness of the compounds has been demonstrated by preclinical and clinical research, and many of the compounds are FDA-approved.

The collections of unique small molecules, which include inhibitors, activators, antagonists, and agonists, are focused on over 200 targets that are part of more than 20 signaling pathways. These pathways include, among many others, apoptosis, PI3K/Akt/mTOR, and MAPK pathways.

Structurally diverse, medicinally active, and cell permeable ◆ Rich documentation with structure, IC50, and customer reviews ◆ NMR and HPLC validated to ensure high purity

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0 5 10 15 20 25 30 35

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Number of

Kinase Inhibitors

Kinase Inhibitor Library

Cat.No.

L1200

Kinase Inhibitor Library

• A unique collection of 378 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)

• Bioactivity and safety confirmed by preclinical research and clinical trials • Some inhibitors have been approved by the FDA

• Most are ATP competitive

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Bioactive Compound Library

Cat.No.

L1700

Bioactive Compound Library

• A unique collection of 1902 bioactive chemical compounds for high throughput screening (HTS) and high content screening (HCS)

• Bioactivity and safety confirmed by preclinical research and clinical trials • Some compounds have been approved by the FDA

• Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Number of Bioactive Compounds

0 5 10 15 20 25 30 35 40 45 50 Othe rs AMPA /kainate Rece ptor Estroge n/proge stoge n Receptor 5 10 0 5 0 0 5 10 15 20 25 30 35 40

(4)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Inhibitor Library FDA-approved Drug Library

Customize Your Library

Toll Free: (877) 796-6397

Phone: (832) 582-8158 www.selleckchem.com [email protected]

4

Excellent Validation, Technical Support and Prompt Delivery

3

Cat.No.

L1100

Inhibitor Library

• A unique collection of 1224 small molecule inhibitors for high throughput screening (HTS) and high content screening (HCS)

• Bioactivity and safety confirmed by preclinical research and clinical trials • Some inhibitors have been approved by the FDA

• Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

PI3K AChR HDAC COX VEGFR EGFR CDK PDE JAK RAAS mTOR MEK c-Met Raf PARP GluR Akt GSK-3 p38 MAPK Bcr-Abl ATPase Bcl-2 IGF-1R ATM/ATR DPP-4 DUB FLT3 HER2 IκB/IKK p53 PLK PPAR Rho Src CFTR Kinesin PDGFR Syk Aromatase Autophagy Caspase Chk FAK GPR Integrase MMP NF-κB PKC ROCK Sirtuin STAT ALK AMPK BTK CETP Factor Xa IAP MAO Mdm2 PDK-1 Pim TNF-alpha c-Kit CRM1 DHFR FAAH FGFR HIF JNK LRRK2 p97 SGLT cAMP CaSR Dynamin FXR IDO PAK PERK P-gp S6 Kinase TRPV APC BACE CCR c-Myc CSF-1R CXCR DNA-PK ERK gp120/CD4 Integrin NOD1 PAFR PKA Survivin Tie-2 VDA Wee1 5-HT Receptor HSP (e.g. HSP90) Sodium Channel Aurora Kinase Calcium Channel Topoisomerase P450 (e.g. CYP17) Androgen Receptor TGF-beta/Smad Proteasome Wnt/beta-catenin Potassium Channel Dehydrogenase Gamma-secretase Opioid Receptor Cysteine Protease DNA/RNA Synthesis HIV Protease Transferase Carbonic Anhydrase Endothelin Receptor GABA Receptor HCV Protease P2 Receptor Serine Protease Hydroxylase OX Receptor Proton Pump S1P Receptor Telomerase 5-alpha Reductase Ferroptosis Liver X Receptor LPA Receptor Adenosine Receptor Beta Amyloid E1 Activating E2 Conjugating E3 Ligase Ephrin receptor MT Receptor IL Receptor Phosphorylase Substance P Adrenergic Receptor Histamine Receptor Estrogen/progestogen Receptor Dopamine Receptor Reverse Transcriptase Epigenetic Reader Domain Histone Methyltransferase Microtubule Associated Cannabinoid Receptor DNA Methyltransferase Hedgehog/Smoothened HMG-CoA Reductase Histone Demethylase AMPA/kainate Receptor Phospholipase (e.g. PLA) Histone Acetyltransferase Procollagen C Proteinase Vasopressin Receptor Others

Cat.No.

L1300

FDA-approved Drug Library

• A unique collection of 1018 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS)

• Locate new targets for old drugs

• Bioactivity and safety confirmed by clinical trials • All compounds have been approved by FDA

• Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Number of FDA-approved Compounds AMPA/kainate Receptor 0 5 10 15 20 25 30 35 40 0 5 Estrogen/progestogen Receptor

(5)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Target Selective Inhibitor Library Epigenetics Compound Library / Natural Product Library

Cat.No.

L1400

Natural Product Library

• A unique collection of 131 natural products for high throughput screening (HTS) and high content screening (HCS)

• Structurally diverse, bioactive, and cell permeable • Rich documentation with structure and IC50

• NMR and HPLC validated ensure high purity

Cat.No.

L1900

Epigenetics Compound Library

• A unique collection of 128 small molecule modulators (inhibitors and activators) with biological activity used for epigenetics research and associated assays. A variety of structurally and mechanistically different compounds are included

• A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure the highest purity

Targets include:

HDAC JAK Aurora Kinase PARP Sirtuin Pim HIF FLT3 CDK EGFR MAO

Epigenetic Reader Domain

Histone Methyltransferase DNA Methyltransferase Histone Demethylase

Histone Acetyltransferase Sodium Channel

Cat.No.

L3500

Target Selective Inhibitor Library

• A unique collection of 464 validated bioactive compounds covering over 140 targets • Each compound was selected based on its ability to principally interact with a single target, leading to minimal off-target activity

• Selectivity is at least 100-fold higher relative to non-primary target(s)

• Targets cover a wide variety of signaling pathways, including PI3K/Akt, MAPK, PTK, JAK, apoptosis, and others

• This unique tool is ideal for studying mechanisms of action or for target screening • Compounds are structurally diverse, biologically active, and cell permeable

• Selleck provides rich supporting documentation which includes compound structure, IC50,

and customer reviews

• Compounds are NMR and HPLC validated to ensure our customers receive high purity compounds

Targets include:

ATM/ATR GluR HDAC RAAS AChR EGFR GPR JAK MEK PI3K PLK Akt ATPase Bcl-2 Bcr-Abl BTK CDK COX DUB IκB/IKK Kinesin MAO MMP p38 MAPK PARP PDE Proteasome Rho STAT VEGFR ALK AMPK Aromatase Caspase CETP CFTR Chk c-Met CRM1 DHFR DPP-4 FAAH Factor Xa FAK FLT3 GSK-3 HIF IAP IGF-1R Integrase Integrase LRRK2 mTOR NF-κB p53 p97 PDGFR PKC PPAR Raf ROCK SGLT Sirtuin Src Syk Telomerase TNF-alpha cAMP CaSR Dynamin Ferroptosis FGFR FXR HER2 Hydroxylase JNK LPA Receptor OX Receptor P2 Receptor PDK-1 PERK P-gp Pim S1P Receptor S6 Kinase Transferase TRPV Beta Amyloid CCR CSF-1R CXCR E1 Activating E2 conjugating E3 Ligase ERK gp120/CD4 IDO MT Receptor NOD1 PAFR PAK PKA Substance P Survivin Tie-2 VDA Wee1 Adrenergic Receptor Histamine Receptor TGF-beta/Smad 5-HT Receptor Cysteine Protease Dopamine Receptor Epigenetic Reader Domain HSP (e.g. HSP90) Aurora Kinase Cannabinoid Receptor Dehydrogenase Estrogen/progestogen Receptor Gamma-secretase Histone Methyltransferase Wnt/beta-catenin Androgen Receptor Calcium Channel Carbonic Anhydrase DNA Methyltransferase Endothelin Receptor GABA Receptor Hedgehog/Smoothened HMG-CoA Reductase Opioid Receptor P450 (e.g. CYP17) Potassium Channel Sodium Channel Topoisomerase 5-alpha Reductase Adenosine Receptor AMPA/kainate Receptor Histone Demethylase Liver X Receptor Microtubule Associated Reverse Transcriptase DNA/RNA Synthesis Histone Acetyltransferase Phospholipase (e.g. PLA) Phosphorylase Serine Protease Vasopressin Receptor Others

Size (Pre-dissolved in DMSO)

(6)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Anti-cancer Compound Library

Customize Your Library

GPCR Compound Library

Toll Free: (877) 796-6397

Phone: (832) 582-8158 www.selleckchem.com [email protected]

8

Excellent Validation, Technical Support and Prompt Delivery

7

Targets include:

Cat.No.

L2200

GPCR Compound Library

• A unique collection of 254 small molecules targeting G protein coupled receptors used in GPCR screening by pharmaceutical and biotechnology companies in various research and drug development projects

• All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity

• A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery.

• It is estimated about 200 so-called orphan GPCRs are functionally unknown, as a result, use of our GPCR Small Molecule Compound Library for screening the functionally unknown GPCRs may yield potentially new GPCR-based drug candidates

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure the highest purity

AChR GluR SGLT cAMP CaSR COX CXCR PDE 5-HT Receptor GABA Receptor P2 Receptor OX Receptor S1P Receptor MT Receptor Opioid Receptor TGF-beta/Smad Adrenergic Receptor Histamine Receptor Dopamine Receptor Gamma-secretase Estrogen/progestogen Receptor Cannabinoid Receptor Hedgehog/Smoothened Endothelin Receptor AMPA/kainate Receptor Others

Targets include:

Cat.No.

L3000

Anti-cancer Compound Library

• A unique collection of 386 anti-cancer small molecules for 12 types of cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc

• This library contains inhibitors of PI3K, HDAC, mTOR, CDK, Aurora Kinase, JAK, etc • Some compounds have been approved by the FDA

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

PI3K HDAC VEGFR EGFR mTOR JAK CDK c-Met Bcr-Abl MEK PLK Aromatase Bcl-2 Kinesin PARP Raf FLT3 Mdm2 p38 MAPK Sirtuin Src Akt c-Kit IGF-1R PDGFR Pim PKC STAT TNF-alpha ATM/ATR Caspase Chk FAK FXR GSK-3 HER2 IL Receptor IκB/IKK JNK PDE PDK-1 Rho SGLT Telomerase AMPK APC Autophagy BTK CCR CETP COX DHFR DNA-PK DUB ERK FAAH FGFR HIF Hydroxylase IAP IDO MMP p53 PAK PERK PPAR ROCK Substance P Survivin Syk Tie-2 Transferase VDA Wee1 DNA/RNA Synthesis Microtubule Associated HSP (e.g. HSP90) Topoisomerase Estrogen/progestogen Receptor Aurora Kinase Androgen Receptor Gamma-secretase Proteasome Wnt/beta-catenin DNA Methyltransferase TGF-beta/Smad Hedgehog/Smoothened S1P Receptor Dehydrogenase Endothelin Receptor Epigenetic Reader Domain Histone Demethylase HMG-CoA Reductase Liver X Receptor Others

(7)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO) Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Cambridge Cancer Compound Library Tyrosine Kinase Inhibitor Library / Stem Cell Signaling Compound Library

Cat.No.

L1800

Tyrosine Kinase Inhibitor Library

• A unique collection of 141 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)

• Bioactivity and safety confirmed by preclinical research and clinical trials • Some tyrosine kinase inhibitors have been approved by FDA

• Structurally diverse, medicinally active and cell permeable • Rich documentation with structure, IC50 and customer reviews

• NMR and HPLC to ensure the high purity

Targets include:

VEGFR EGFR c-Met Bcr-Abl IGF-1R FLT3 HER2 Src PDGFR Syk FAK ALK BTK c-Kit FGFR JAK CSF-1R mTOR Tie-2 VDA Ephrin receptor

Cat.No.

L2100

Stem Cell Signaling Compound Library

• A unique collection of 81 small molecule inhibitors with biological activity used for stem cell regulatory and signaling pathway research. All of the small molecule inhibitors in the stem cell screening library are well characterized with biological and pharmaceutical activity

• A powerful tool for researching the mechanism behind stem cells, regenerative therapy, means differentiation, drug screening based on tumor stem cells, as well as other pharmaceutical and biological applications

• The stem cell inhibitor library contains small molecules associated with signaling pathways which modulate the function of stem cells such as Wnt, Notch, SMAD, and Hedgehog signaling • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure the highest purity

Targets include:

JAK GSK-3 Wnt/beta-catenin TGF-beta/Smad Gamma-secretase Hedgehog/Smoothened PKC ROCK Bcr-Abl STAT BACE EGFR Sirtuin Others

Cat.No.

L2300

Cambridge Cancer Compound Library

• A highly value-added library derived through a collaboration with researchers at the MIT Koch Institute

• A unique collection of 313 cancer-targeted compounds for high throughput screening (HTS) and high content screening (HCS)

• Embraces the whole spectrum of cancer targets, from kinases to Notch signaling, to metabolic targets

• Structurally diverse, medicinally active and cell permeable • Rich documentation with structure and IC50

• NMR and HPLC to ensure the high purity

Targets include:

PI3K HDAC VEGFR mTOR CDK c-Met EGFR JAK Bcr-Abl PARP Raf Bcl-2 FLT3 MEK Sirtuin Src Kinesin PDGFR PLK Akt ATM/ATR Chk c-Kit FAK FXR GSK-3 IGF-1R IκB/IKK PKC SGLT AMPK APC BTK Caspase CCR CETP COX DHFR DNA-PK FAAH FGFR HIF Mdm2 NF-κB p53 PDE PDK-1 Pim PPAR Rho ROCK STAT Survivin Syk Tie-2 VDA Wee1 Aurora Kinase Aromatase p38 MAPK Proteasome TGF-beta/Smad S1P Receptor Telomerase TNF-alpha Autophagy IL Receptor S6 Kinase Substance P Transferase Topoisomerase DNA/RNA Synthesis Estrogen/progestogen Receptor Microtubule Associated Androgen Receptor DNA Methyltransferase HSP (e.g. HSP90) Gamma-secretase Hedgehog/Smoothened Dehydrogenase Endothelin Receptor Histone Methyltransferase HMG-CoA Reductase Liver X Receptor Wnt/beta-catenin Others

(8)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Customize Your Library

Pfizer Licensed Compound Library Autophagy Compound Library / Ion Channel Ligand Library

Toll Free: (877) 796-6397

Phone: (832) 582-8158 www.selleckchem.com [email protected]

12

Excellent Validation, Technical Support and Prompt Delivery

11

Targets include:

Cat.No.

L2400

Pfizer Licensed Compound Library

• All 85 compounds are licensed by Pfizer and have been marketed or clinically proven bioactive • Wide range of potential uses: from anti-cancer compounds (Bosutinib) to a glycylcycline antiobiotic (Tigecycline) to combat the growing prevalence of antibiotic resistance • Purchase as a diverse library or individually to meet your drug-discovery needs

• Reliability Guarantee: All compounds are developed, validated, and manufactured by Pfizer • All compounds are validated using NMR and HPLC

• Detailed preclinical research data and safety information available

c-Met COX MEK PDE RAAS AChR mTOR PDGFR VEGFR CCR CDK CETP EGFR FAAH FAK FGFR HER2 JAK PI3K Src Factor Xa p38 MAPK S6 Kinase Topoisomerase 5-HT Receptor Adrenergic Receptor Aromatase Estrogen/progestogen Receptor P450 (e.g. CYP17) Proton Pump Sodium Channel Autophagy Calcium Channel DNA/RNA Synthesis Dopamine Receptor Epigenetic Reader Domain Hedgehog/Smoothened Histamine Receptor HMG-CoA Reductase HSP (e.g. HSP90) Phosphorylase Potassium Channel Procollagen C Proteinase Others

Cat.No.

L2600

Autophagy Compound Library

• A unique collection of 152 small molecules with autophagy-inducing or autophagy-inhibiting activity

• A useful tool for studying the roles of molecules in autophagy

• Targets Proteasome, HIF, HDAC, Aurora Kinase, Sirtuin, E3 Ligase, Calcium Channel, mTOR, etc • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

HDAC mTOR Proteasome PI3K DUB Autophagy p53 Sirtuin HIF LRRK2 Bcl-2 cAMP EGFR FLT3 p97 Pim ROCK APC ATPase Bcr-Abl CDK E1 Activating E3 Ligase IL Receptor IκB/IKK JAK Mdm2 PDGFR Proton Pump Survivin TNF-alpha Aurora Kinase Calcium Channel Microtubule Associated Adrenergic Receptor DNA/RNA Synthesis Dopamine Receptor Epigenetic Reader Domain Estrogen/progestogen Receptor HSP (e.g. HSP90) Opioid Receptor Potassium Channel Serine Protease Sodium Channel Topoisomerase

Targets include:

Cat.No.

L2700

Ion Channel Ligand Library

• A unique collection of 52 small molecule modulators used for Ion channel research • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

(9)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Cat.No.

L3400

MAPK Inhibitor Library

• A unique collection of 44 small molecule inhibitors used for MAPK signaling research • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

MEK Raf p38 MAPK JNK ERK

Cat.No.

L2800

PI3K/Akt Inhibitor Library

• A unique collection of 98 small molecule inhibitors used for PI3K/Akt/mTOR pathway research • A valuable tool for researching the survival, proliferation, and apoptosis of cells

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

PI3K mTOR Akt GSK-3 ATM/ATR AMPK PDK-1 S6 Kinase DNA-PK EGFR HDAC PDGFR PKA Sirtuin Other

Cat.No.

L3300

Apoptosis Compound Library

• A unique collection of 35 small molecules used for apoptosis research • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

Bcl-2 p53 Caspase IAP Mdm2 TNF-alpha PERK Survivin

Cat.No.

L2500

Protease Inhibitor Library

• A unique collection of 43 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS)

• Bioactivity and safety confirmed by preclinical research and clinical trials • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Targets include:

Proteasome DPP-4 Gamma-secretase HIV Protease HCV Protease Serine Protease Caspase Cysteine Protease MMP BACE Others

(10)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Size (Pre-dissolved in DMSO)

100 μL/well (10 mM solution) 250 μL/well (10 mM solution)

Targets include:

Cat.No.

L2900

Anti-diabetic Compound Library

• A unique collection of 32 small molecules affecting the development of diabetes • Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

DPP-4 PPAR GPR SGLT AMPK PARP Sirtuin Potassium Channel Calcium Channel Dehydrogenase Endothelin Receptor P450 (e.g. CYP17) Transferase Others

Targets include:

Cat.No.

L3100

Anti-infection Compound Library

• A unique collection of 118 anti-infective small molecules with biological activity of antibiotics, antifungal drugs,anti-HIV,etc

• The compounds in this library mainly include sulfonamides, aminoglycosides, tetracyclines and macrolides

• A useful tool to research infectious disease for academic institutions, medical research organizations, and the pharmaceutical industry

• Structurally diverse, medicinally active, and cell permeable • Rich documentation with structure, IC50, and customer reviews

• NMR and HPLC validated to ensure high purity

Integrase PARP Autophagy CCR DHFR NF-κB Reverse Transcriptase HIV Protease HCV Protease DNA/RNA Synthesis Estrogen/progestogen Receptor Topoisomerase Cysteine Protease P450 (e.g. CYP17) Serine Protease Others

Customize Your Library

Anti-infection Compound Library / Anti-diabetic Compound Library

Excellent Validation, Technical Support and Prompt Delivery

(11)

Headquarters

Technical Support

Tel: +1 832 582-8158 x3

E-mail: [email protected] (We strive to reply to all email inquiries within one business day.)

Order & Inquiry

Delivery

Europe

Tel: +49 89 46148500 (Language: English, French, Spanish, German) Fax: +49 89 461485022

E-mail: [email protected]

E-mail: [email protected]

Order & Inquiry

Delivery

United States

E-mail:[email protected] Tel:+1 713 535-9129 Toll Free: +1 877 796-6397 Tel: +1 832 582-8158 Fax: +1 832 582-8590 E-mail: [email protected]

References

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