WIDAD UNIVERSITY COLLEGE WIDAD UNIVERSITY COLLEGE
FACULTY OF ALLIED HEALTH SCIENCES FACULTY OF ALLIED HEALTH SCIENCES
CASE STUDY
CASE STUDY
AMNIOTIC FLUID EMBOLISM
AMNIOTIC FLUID EMBOLISM
POSTING UNIT: LABOR ROOM, HOSPITAL TENGKU AMPUAN AFZAN POSTING UNIT: LABOR ROOM, HOSPITAL TENGKU AMPUAN AFZAN
(HTAA), KUANTAN, PAHANG. (HTAA), KUANTAN, PAHANG.
NAME: MOHAMAD RAIS BIN MOHD
NAME: MOHAMAD RAIS BIN MOHD SHUHAIMISHUHAIMI MA
MATRIC TRIC NUMBER: NUMBER: SP511!"!#SP511!"!# I$C
CONTENTS NO CONTENT PAGE 1. D*++-+ 1 . C/0 1 !. S+2 /3 S46- %. D+/2+ ! 5. M//2- % 7. C68+9/-+ 7 &. P2+ 7 . R*9 &
DEFINITION
Amniotic fluid embolism is a rare but serious condition that occurs when amniotic fluid the fluid that surrounds a baby in the uterus during pregnancy or fetal material, such as fetal cells, enters the mother's bloodstream. Amniotic fluid embolism is most likely to occur during delivery or
immediately afterward.
CAUSES
It is thought that this condition results from amniotic fluid entering the maternal circulation via the uterine veins, which then has either a direct effect on the lungs, or triggers an immune response in the mother.
In order for amniotic fluid to enter the maternal circulation, there are three prerequisites:
• Ruptured membranes a term used to define the rupture of
the amniotic sac!
• Ruptured uterine or cervical veins
• A pressure gradient from uterus to vein
Although e"posure to fetal tissue is common and thus finding fetal tissue within the maternal circulation is not significant, in a small percentage of women this e"posure leads to a comple" chain of events resulting in collapse and death. #here is some evidence that Amniotic $luid %mbolism A$%! may be associated with abdominal trauma or amniocentesis. A &( study showed that the use of drugs to induce labor, such as misoprostol, nearly doubled the risk of A$%. A maternal age of )* years or older, caesarean or instrumental vaginal delivery, polyhydramnios, cervical laceration or uterine rupture, placenta previa or abruption, eclampsia, and fetal distress were also associated with an increased risk.
SIGNS AND SYMPTOMS
+igns and symptoms of amniotic fluid embolism might include:
• +udden shortness of breath
• %"cess fluid in the lungs pulmonary edema!
• +udden failure of the heart to effectively pump blood cardiovascular
collapse!
• ife-threatening problems with blood clotting disseminated
intravascular coagulopathy!
• Altered mental status, such as an"iety
• hills
• Rapid heart rate or disturbances in the rhythm of the heart rate
• $etal distress, such as a slow heart rate
• +ei/ures
• oma
• +udden fetal heart rate abnormalities
• 0leeding from the uterus, incision or intravenous I1! sites
DIAGNOSIS
#he diagnosis of amniotic fluid embolism is based on a doctor's evaluation. A diagnosis is typically made after other conditions have been ruled out. In
some cases, a diagnosis is only made after maternal death.
• 0lood tests, including those that evaluate clotting, heart en/ymes,
electrolytes and blood type, as well as a complete blood count 0!
• %lectrocardiogram %2 or %32! to evaluate heart rhythm
• 4ulse o"imetry to check the amount of o"ygen in blood
• hest 5-ray to look for fluid around heart
• %chocardiography to evaluate heart function
MANAGEMENT M3+9/8 C/
Admit the patient with amniotic fluid embolism A$%! into the intensive care unit I6!.
• Administer o"ygen to maintain normal saturation. Intubate if
necessary.
• Initiate cardiopulmonary resuscitation 4R! if the patient arrests.
If she does not respond to resuscitation, perform a perimortem cesarean delivery.
• #reat hypotension with crystalloid and blood products. 6se
pressors as necessary.
• Avoid e"cessive fluid administration. 7uring the initial phase, right
ventricular function is suboptimal. %"cess fluid may overdistend the Right ventricle which could increase the risk of a right sided myocardial infarction.
• onsider pulmonary artery catheteri/ation in patients who are
hemodynamically unstable.
• ontinuously monitor the fetus. 7eliver immediately following
cardiac arrest if gestational age is 8 &) weeks. %arly evaluation of clotting status and early initiation of massive transfusion protocols is recommended.
• #reat coagulopathy with fresh fro/en plasma $$4! for a prolonged
activated partial thromboplastin time a4##!, cryoprecipitate for a
fibrinogen level less than 9 mgd, and transfuse platelets for platelet counts less than &,;.
<emodialysis with plasmapheresis and e"tracorporeal membrane o"ygenation %=>! with intra-aortic balloon counterpulsation have been described in case reports with successful outcomes in treating A$% patients with cardiovascular collapse. #he use of anticoagulation during %=> may worsen bleeding in patients with A$%. 6se of %=> is not routinely recommended.
S02+9/8 C/
4erform emergent cesarean delivery in arrested mothers who are unresponsive to resuscitation.
COMPLICATIONS
• sudden cardiac arrest • e"cessive blood loss
• acute respiratory distress • multiple organ failure
PROGNOSIS
+urvival after Amniotic $luid %mbolism A$%! has improved significantly with early recognition of this syndrome and prompt and early resuscitative measures.
#he decrease in the mortality rate results solely from early diagnosis and prompt treatment rather than prevention of the syndrome, since the cause is unknown. #hose women who survive long enough to be transferred to the I6 have a better chance of survival. Although mortality rates have declined, morbidity remains high with severe sequelae, particularly neurologic impairment.
REFERENCES
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