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Basic Human Pathology Lecture #5 Acute Inflammation / Wound ...

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Overview: Tissue Responses to Damage

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Formation of Acute Inflammatory Exudate

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Formation of an Acute Inflammatory Exudate

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Clinical Effects of Acute Inflammation

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“4 + 1” Cardinal Signs of Inflammation

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Acute Inflammation/Wound Healing and Repair I

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Key Facts - Neutrophils

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Acute Inflammation/Wound Healing and Repair I

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Neutrophil Granules and Their Contents

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Acute Inflammatory Response

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Neutrophilic phagocytosis - cont’d

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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White Blood Cells (a.k.a. leukocytes or WBC’s)

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Parulis (gum boil; abscess on the gingiva) = localized accum...

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Pus draining from a fistula of an abscessed tooth

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Acute Inflammation/Wound Healing and Repair I

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Fibrinous Exudate – Pericardium

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Purulent Exudate of the Brain

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Abscess in the Skin = Localized Accumulation of Neutrophils...

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Acute Inflammatory Response

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Acute Inflammatory Response

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Acute Inflammatory Response

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Acute Inflammatory Response

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Acute Inflammatory Response

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Acute Inflammatory Response

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

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Cell Membrane Phospholipids

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Endogenous Mediators:

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Acute Inflammatory Response

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Biosynthesis of Leukotrienes and Lipoxins

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

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Acute Inflammation Mechanisms

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Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Overview of the Complement System

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Acute Inflammation Mechanisms

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Acute Inflammation/Wound Healing and Repair I

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Acute Inflammation Mechanisms

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Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair I

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Acute Inflammatory Response

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Acute Inflammation/Wound Healing and Repair I

References

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