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The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

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Academic year: 2021

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Figure

FiGuRe 1 | inflammasome sensors and activators. A wide variety of pathogenic ligands and intracellular mediators are involved in inflammasome assembly
TAbLe 1 | Molecular and clinical features of autoinflammatory diseases associated with mutations in inflammasome sensor proteins.
FiGuRe 2 | Regulatory mechanisms of NLRP3 inflammasome assembly. The expression levels of NLRP3 are regulated by miR-223 in basal conditions but  can be upregulated after cell recognition of pathogen-associated molecular patterns that induce NF- κB signali

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