1,25-dihydroxyvitamin D3
Inhibition of T lymphocyte mitogenesis by 1,25 dihydroxyvitamin D3 (calcitriol)
... 1,25-dihydroxyvitamin D3 (calcitriol), the most biologically active metabolite of vitamin D, upon phytohemagglutinin (PHA)-induced lymphocyte blast ...
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1,25 Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels
... 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) induces the differentiation of normal human keratinocytes, in part by increasing their basal intracellular calcium levels (Cai) over a period of ...
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1, 25 Dihydroxyvitamin D3 Protects the Heart Against Pressure Overload-induced Hypertrophy without Affecting SIRT1 mRNA Level
... Sirtuin 1 (SIRT1) is regarded as a key deacetylase enzyme in cardiomyocytes which applies potential cardioprotective effects by functional regulation of different ...of 1, 25-dihydroxyvitamin ...
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Evidence that 1,25 dihydroxyvitamin D3 inhibits the hepatic production of 25 hydroxyvitamin D in man
... of 25-hydroxyvitamin D ...1,25-dihydroxyvitamin D3 [1,25(OH)2D3] would alter the response of serum 25-OHD to challenge with vitamin ...serum 25-OHD, from ...serum 25-OHD in ...
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Enterohepatic physiology of 1,25 dihydroxyvitamin D3
... 1,25-dihydroxyvitamin D3 were excreted in bile was not saturable in the dose range tested ...1,25-dihydroxyvitamin D3 present in bile were found to be much more polar than ...
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Renal Hypophosphatemic Rickets: Growth Acceleration After Long-Term Treatment with 1,25-Dihydroxyvitamin-D3
... Treatment with 1,25-dihydroxyvitamin-D3 and phosphorus supplementation for as long as 48 months was evaluated in six patients with renal hypophospha-.. temic rickets.[r] ...
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1,25 Dihydroxyvitamin D3 production by human keratinocytes Kinetics and regulation
... metabolize 25-hydroxyvitamin D3 to a number of metabolites, including 1,25-dihydroxyvitamin D3 ...for 25-hydroxyvitamin D3 of ...
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Effect of age on the conversion of 25 hydroxyvitamin D3 to 1,25 dihydroxyvitamin D3 by kidney of rat
... dihydroxyvitamin D3 after 24 h compared with ...tritiated 25-hydroxyvitamin D3 to its products was also measured directly in isolated slices of renal ...1,25-Dihydroxyvitamin D3 ...
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Vitamin D dependent rickets type II Defective induction of 25 hydroxyvitamin D3 24 hydroxylase by 1,25 dihydroxyvitamin D3 in cultured skin fibroblasts
... 1,25(OH)2D or vitamin D-dependent rickets type II (DD II). Fibroblasts were preincubated with varying concentrations of 1,25(OH)2D3 for 15 h and were then incubated with 0.5 microM [3H]25(OH)D3 at 37 ...
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1,25-Dihydroxyvitamin D3 and Development of Tuberculosis in Cattle
... In a repeat experiment using five experimentally infected FIG. 3. Inhibition of PBMC proliferation to ESAT-6 (a) and ConA (b) by a monoclonal antibody to the VDR. Antigen and mitogen concentrations were both 5 g/ml. ...
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Influence of the Vitamin D binding Protein on the Serum Concentration of 1,25 Dihydroxyvitamin D3: SIGNIFICANCE OF THE FREE 1,25 DIHYDROXYVITAMIN D3 CONCENTRATION
... At the end of pregnancy, the total concentrations of 1,25-(OH) 2 D 3 (97±26 ng/liter, n = 40) and DBP (616±84 mg/liter) are both significantly higher than in nonpregnant females and paired cord serum samples (48±11 ...
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Regulation of 1,25 dihydroxyvitamin D3 receptor gene expression by 1,25 dihydroxyvitamin D3 in the parathyroid in vivo
... 1,25(OH)2D receptor (VDR) in the parathyroid in vivo. Rats were injected with 1,25(OH)2D3 and the parathyroid-thyroid tissue analyzed for PTHmRNA and VDRmRNA. 1,25(OH)2D3 (50 and 100 pmol ip) decreased PTHmRNA at 6 h ...
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25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression
... Measurement of vitamin D metabolites was performed by liquid chromatography tandem- mass spectrometry (LC-MS/MS) as previously described [7]. Briefly, samples were prepared for analysis by protein precipitation followed ...
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Chronic 1,25 dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25 hydroxyvitamin D by increasing metabolic clearance rate
... of 25-OH-D to 24,25(OH)2D3 by kidney homogenates. The reduction in serum 25-OH-D3 was completely accounted for by an increase in ...serum 25-OH-D3 and 24,25(OH)2D3 was shown not to be ...
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Original Article Effect of 1, 25-Dihydroxyvitamin D3 on triglyceride content and expressions of protein tyrosine phosphatase-1B in liver of type 2 diabetes mellitus rat
... Protein tyrosine phosphatase-1B (PTP-1B) was one new therapeutic target towards the treat- ment of type 2 diabetes mellitus (T2DM), obe- sity and dyslipidemia, etc. The latest studies had found that PTP-1B was closely ...
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Influence of 1α, 25 dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes
... The transient receptor potential (TRP) superfamily is a non-selective cation ion channels with relative calcium selectivity. The TRPV sub-family is divided into two groups. TRPV1-4 channels are non-selective ion channels ...
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1 alpha,25 dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells
... 1,25-(OH)2- D3 on DNA synthesis and Ig production by normal human peripheral blood mononuclear (PBM) cells activated in vitro by the polyclonal lymphocyte activators pokeweed mitogen and phytohemagglutinin, and ...
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1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier
... The present study examined the [ 125 I]hAb(1-40) elimi- nation from the brain for 60 min, and considerable degradation of injected [ 125 I]hAb(1-40) might occur dur- ing this period. However, we showed ...
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Vitamin D and respiratory tract infections in childhood
... Abbreviations 1,25[OH]D: 1,25-dihydroxyvitamin D3; 25OHD: 25-hydroxycholecalciferol; ALRI: Acute lower respiratory tract infection; AOM: Acute otitis media; ARS: Acute rhinosinusitis; CA[r] ...
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Ligation of TLR9 induced on human IL 10–secreting Tregs by 1α,25 dihydroxyvitamin D3 abrogates regulatory function
... neutral conditions or with 1α25VitD3 (open bar) until day 14 (t0). Cells cultured with 1 α 25VitD3 for 14 days were then restimu- lated with (filled squares) or without (open diamonds) 1α25VitD3 for up 2 weeks. ...
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