1,4 dihydropyridine
QSAR STUDIES ON NOVEL 1, 4 DIHYDROPYRIDINE DERIVATIVES
... -diphenyl-1, 4- dihydropyridine-3, 5-dicarbohydrazides [2A-2D’] and 2, 6-dimethyl- 1,4-dihydro-pyridine-3, 5-yl-bis[carbonyl-2-(phenyl)]pyrazolidine-3, 5-diones] [3A -3D’] were carried ...
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Synthesis and Antitubercular Activity of N3,N5-Diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-
... The development of a reproducible screening procedure for tuberculosis infection permitted to introduce 1,4-DHPs as a prototype of anti-tuberculosis agents [6]. It could be seen from pervious study [5] that an aryl-amid ...
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SYNTHESIS AND CHARACTERIZATION OF 2,6-DICHLORO-1-(NSUBSTITUTED PHENYL)-1,4-DIHYDROPYRIDINE-3,5- DICARBALDEHYDES AND THEIR TRANSFORMATION INTO EFFECTIVE ANTIFUNGAL 4-THIAZOLIDINONE DERIVATIVES
... phenyl)-1,4- dihydropyridine-3,5-dicarbaldehyde (1mmole) was refluxed with two different aromatic primary amines(2mmole) in water bath for 4-5 hours using ethanol as solvent and few drops of glacial acetic ...
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Anticonvulsant, analgesic and anti inflammatory activities of some novel pyrrole and 1,4 dihydropyridine derivatives
... In recent years, the high therapeutic properties of thiosemicarbazone and their heterocyclic related drugs have been attracting the attention the medicinal chemists. Pyrrole and 1,4-dihydropyridine derivatives ...
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HKUST-1 as an efficient and reusable heterogeneous catalyst for synthesis of 1,4-dihydropyridine at room temperature
... A mixture of aldehyde (1 mmol), ethyl acetoacetate (2 mmol), ammonium acetate (1 mmol) and HKUST-1 (10 mg) was stirred in a flask containing 5 mL ethanol for the appropriate time. The progress of the ...
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Synthesis of Novel 1,4- Dihydropyridine Derivatives Bearing Biphenyl-2'-Tetrazole Substitution as Potential Dual Angiotensin II Receptors and Calcium Channel Blockers
... of 4- or 5-carboxaldehyde intermediate was first removed in acidic media and then classical Hantzsch reaction was employed in order to obtain the final ...protected 4- or 5-carboxaldehyde intermediate ...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2,6 BIS((E) (2 HYDROXYNAPHTHALEN 1 YL)DIAZENYL) 1 SUBSTITUTED PHENYL 1,4 DIHYDROPYRIDINE 3,5 DICARBALDEHYDE
... An entire new series of 2,6-bis((E)-(2-hydroxynaphthalen-1-yl)diazenyl)-1-substitutephenyl- 1,4-dihydropyridine-3,5-dicarbaldehyde 5a-j have been synthesized in a facile manner from ...
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SYNTHESIS, CHARACTERIZATION AND DEVELOPMENT OF VALIDATED RP HPLC METHOD FOR THE ESTIMATION OF PROCESS RELATED IMPURITY DIETHYL 4 (4 CHLOROPHENYL) 2, 6 DIMETHYL 1, 4 DIHYDROPYRIDINE 3, 5 DICARBOXYLATE FROM AMLODIPINE BULK AND FORMULATION
... A successful hantzsch pyridine synthesis method was developed for the synthesis of diethyl 4-(4-chlorophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylate impurity. The ...
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VIRTUAL TOXICITY STUDIES OF NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES
... All the derivatives except 3C showed the computed probability value less than 0.7 and negative discriminant scores are not likely to produce a positive response in an experimental assay and negative contribution to the ...
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An efficient One pot Synthesis of 1, 4 Dihydropyridine Derivatives under Solvent free Condition
... of 1, 4 – Dihydropyridines were accomplished by the condensation of Acetoacetnilide, Aromatic aldehydes and Ammonium acetate in the presence of Bismuth trichloride as catalyst under solvent free ...
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Synthesis, crystal structure and Hirshfeld surface analysis of diethyl 2,6 dimethyl 4 (thiophen 3 yl) 1,4 dihydropyridine 3,5 dicarboxylate
... 1,4-Dihydropyridine derivatives exhibit a large range of biological activities (Stout & Meyers, 1982; Wei et al., 1989; Bossert & Vater, 1989; Mauzerall & Westheimer, 1955). They have been used as ...
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A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG- ...
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Efficient Procedure for Preparation of 1,4-Dihydropyridines under Green Chemistry Conditions
... Observing the biological and medicinal properties of these 1,4-dihydropyridine derivatives, herein an efficient, economic, straightforward multicomponent reaction involving ethylacetoacetate, arylaldehyde and ...
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Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three- component reaction of various aldehydes, ethyl ...
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4 (4 Bromophenyl) 2,5 diethoxycarbonyl 6 methylthieno[2,3 b]pyridine
... a 4- (4-bromophenyl)-substituted thieno[2,3-b]pyridine, obtained by the reaction of ethyl 4-(4-bromophenyl)-6-chloro-5-formyl- 2-methyl-1,4-dihydropyridine-3-carboxylate (Verdecia et ...
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Synthesis and establishment of Amlodipine impurity G reference standard
... Dimethyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which is impurity of amlodipine besilate was synthesized. Hantzsch condensation of methyl acetoacetate with 2-chlorobenzadehyde ...
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3 Methyl 4 nitrophenol–4 dimethylaminopyridine (1/1)
... Data collection: APEX2 Bruker, 2008; cell refinement: SAINT Bruker, 2008; data reduction: SAINT; programs used to solve structure: SHELXS97 Sheldrick, 2008; programs used to refine struc[r] ...
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4 (4 Carboxybenzyl) 1 methylpiperazin 1 ium picrate
... , is a salt obtained by cocrystallization of 4-[(4-methylpiperazin-1- yl)methyl]benzoic acid and picric acid. The cations adopt an ‘L-shaped’ conformation and are linked into chains along [010] by ...
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4 [4 Dimethylamino 1 (4 fluorophenyl) 1 hydroxybutyl] 3 (hydroxymethyl)benzonitrile
... 1-Bromo-4-fluorobenzene (1.6 g, 9 mmol) in tetrahydrofuran (THF) was converted to the Grignard reagent, with ethyl magnesium bromide (1.3 g, 9.9 mmol), and added to 5-cyanophthalide (1.4 g, 8.8 mmol) in THF ...
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1 [4 (4 Hydroxyphenyl)piperazin 1 yl]ethanone
... The molecular structure of the title compound is illustrated in Fig. 1. The piperazine ring has a chair conformation with puckering parameters (Cremer & Pople, 1975), Q, θ, and φ = 0.5661 (13) Å, 174.05 (12)° ...
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