12/15-Lipoxygenase
12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... at 15 mA constant current for stacking, and at 25 mA for pro- tein ...against 12/15-lipoxygenase, or phosphory- lated p38 MAPK, ERK, or SAPK/JNK were applied at 4˚C overnight, after which ...
10
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12- HETE and 13-HODE in animal models
... Human 15-lipoxygenase 1 (15-LOX-1) converts LA to anti-tumor 13-S-hydroxyoctadecadienoic acid (13-HODE) and 15-LOX-2 converts AA to 15-hydroxyeicosatetraenoic acid ...human ...
10
12/15 lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function
... that 12/15-lipoxygenase–meditated (12/15-LO–mediated) enzymatic lipid oxidation regulates DC activation and fine-tunes consecutive T cell ...Specifically, 12/15-LO ...
12
Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... intertwining 12/15- lipoxygenase, oxidation of LDL, and atherosclerosis lesion development? The 12/15-lipoxygenases are cytosolic intracellular enzymes that can interact with plasma ...
9
Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
... accumulation. 12/15-LOX-deficient myeloid splenocytes exhibited similar levels of total but decreased nuclear accumulation of ...that 12/15-LOX regulates ICSBP/IRF-8 nuclear accumulation ...
211
Brem, Christian (2018): Effekte der Lipoxygenase-12/15- und der Lipoxygenase-5-Hemmung auf die Entwicklung des sekundären Hirnschadens nach experimentellem Schädel-Hirn-Trauma. Dissertation, LMU München: Medizinische Fakultät
... der Lipoxygenase-12/15 vor Trauma das Gesamtvolumen des Hirnschadens nach Schädelhirntrauma ...LOX- 12/15 Inhibition das Gesamtüberleben von neuronalen Zellen nach glutamatinduziertem ...
101
Macrophage mediated 15 lipoxygenase expression protects against atherosclerosis development
... human 15-LO cDNA (12), a generous gift from ...the 15-LO ...the 15-LO transgenic rabbits were crossbred with WHHL rabbits that had been derived from English half-lop rabbits ...
9
Systems pharmacology based approach to investigate the in vivo therapeutic efficacy of Albizia lebbeck (L ) in experimental model of Parkinson’s disease
... Arachidonate 12- lipoxygenase, 12S-type; ALOX12B: Arachidonate 12-lipoxygenase, 12R-type; ALOX15: Arachidonate 15-lipoxygenase; ALOX15B: Arachidonate 15- ...
16
Expression of 5 lipoxygenase and 15 lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
... humans, 15-LO exists as two different enzymes with different cell localizations and product profiles ...[10]. 15-LO-1 converts AA to an unstable intermediate, 15- hydroperoxyeicosatetraenoic acid, ...
11
In vivo action of 15 lipoxygenase in early stages of human atherogenesis
... a 15-lipoxygenase in hu- man atheroma (10) and in lesions of cholesterol-fed rabbits (11), but its absence in normal vessel ...a 12 wk feeding period indicating the in vivo activity of the enzyme ...
7
Human articular chondrocytes express 15 lipoxygenase 1 and 2: potential role in osteoarthritis
... 5-LOX, 12-LOX, and 15-LOX. Two different human 15-LOXs have been identified that differ in tissue distribution and substrate ...preferences. 15- LOX-1 is expressed in reticulocytes, ...
12
Phenotype prediction for mucopolysaccharidosis type I by in silico analysis
... 15-LOX-DICE: 15-Lipoxygenase Differentiation Control Element; GAG: glycosaminoglycans; HGMD: human gene mutation database; HMM: hidden Markov model; hnRNP: heterogeneous nuclear ribonucleoproteins; ...
14
Arachidonate 15 lipoxygenase is required for chronic myeloid leukemia stem cell survival
... arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the survival of leukemia stem cells (LSCs) in a murine model of BCR-ABL–induced chronic myeloid leukemia ...of 15-LO function ...
17
Giri_EBJ_2012(2011-12-15)
... 12 JPCalcW is based on the reduced models of liquid junction potentials that uses the generalized Henderson liquid junction potential equation (Bard and Faulkner 2000; Barry and Diamond 1970; Barry 1989; Barry and ...
37
Vol 15, No 12 (2016)
... A recent survey investigating conceptions of assessment among faculty and students in higher education contained both quantitative and qualitative items (DiLoreto, 2013[r] ...
10
Vol 15, No 12 (2016)
... One does not need to conduct too much research to come across blanket statements that point to the increasing discrepancy between the academic outcomes of boys and[r] ...
34
Vol 15, No 12 (2016)
... In light of the above, this study outlines one method of teaching a literary text, the novel, in a university literature course focusing on students‟ vocabulary development ov[r] ...
19
Vol 15, No 12 (2016)
... The Israeli Managing Director Circular (Ministry of Education, Culture and Sport, 2006) which specifies the mathematics curriculum for elementary schools, is grounded in th[r] ...
18
Vol 15, No 12 (2016)
... Service-learning projects allow students to think outside of the box. These projects provide real-life knowledge that they might not have acquired otherwise. “Students may feel empowered by their experiences to assist ...
12
Vol 15, No 12 (2016)
... choices of using research-based practices seemed to occur in a much more haphazard manner without seeming to give much thought as to why she was using the practices she had chosen. Sara also placed much more emphasis on ...
28