2′,3′-cyclic nucleotide
Expression, purification, and initial characterization of different domains of recombinant mouse 2',3' cyclic nucleotide 3' phosphodiesterase, an enigmatic enzyme from the myelin sheath
... 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNPase) is an enzyme expressed abundantly in myelin. In myelin, CNPase is localized in the non-compact regions, such as the periaxonal ...
7
Expression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro
... 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is a protein that hydrolyzes cyclic nucleotides to mono- phosphates (2′ ...Ca 2+ fluxes and may regulate the ...
17
Dual implication of 2',3' cyclic nucleotide 3' phosphodiesterase as major autoantigen and C3 complement binding protein in the pathogenesis of multiple sclerosis
... mune response in MS using molecular immunological ap- proaches combined with Edman chemical sequencing and mass spectrometry to characterize peptides and other mole- cules complexed with Ig, MHC molecules, and heat shock ...
10
Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: glial proteins associated with cell damage and loss
... and 2 ′ , 3 ′ -cyclic nucleotide 3 ′ -phosphodiesterase (CNPase) were analysed through Western blotting of hydrocephalic CSF samples (n = 17) and compared with data from CSF of normal ...
12
Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes
... CNP: 2 ′ ,3 ′ -Cyclic nucleotide 3 ′ phosphodiesterase; DA: Dopaminergic; DAPI: 4 ′ -6-Diamidino-2- phenylindole; DAT: Dopamine transporter; DAZL: Deleted in azoospermia-like ...
19
LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
... file 2: Figure S2a, ...coexpressed 2’ ,3’-cyclic nucleotide 3′ phosphodiesterase (CNPase), a cell type-specific marker of oligodendrocytes (Figure ...
11
Establishment of transgene-free induced pluripotent stem cells reprogrammed from human stem cells of apical papilla for neural differentiation
... CNPase: 2 ’ , 3 ’ -cyclic nucleotide-3 ’ - phosphodiesterase; (D)MEM: (Dulbecco ’ s) modified Eagle ’ s medium; DPSCs: dental pulp stem cells; EBs: embryoid bodies; ESCs: embryonic stem ...
11
Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis
... ligand 2; CD: Cluster of differentiation; CNPase: 2 ′ ,3 ′ -cyclic-nucleotide 3 ′ -phosphodiesterase; CNS: Central nervous system; DAPI: 4 ′ ,6-diamidino-2-phenylindole; ...
18
In vitro behavior of human intestinal mucosa The influence of acetyl choline on ion transport
... The possibility that the autonomic nervous system may influence the function of intestinal mucosa was investigated by assessing the effect of acetyl choline on ion transport in human intestine. Isolated pieces of ...
9
The Effects of the Immunologic Release of Histamine upon Human Lung Cyclic Nucleotide Levels and Prostaglandin Generation
... The effect of the antigen-induced, immunoglobulin (Ig)E-dependent release of mediators from human lung tissue was analyzed for coincident changes in the tissue levels of cyclic nucleotides. Simultaneously with the ...
10
The arabidopsis cyclic nucleotide interactome
... To investigate whether the candidate CNBPs contain potential CNBDs, their sequences were aligned with known CNBDs. To achieve this, CNB domains were ex- tracted from representative organisms across kingdoms including ...
18
The effects of cyclophosphamide and its derivatives on cyclic nucleotide metabolism
... In human lung, A-PDE exhibits a Km for cyclic AMP of 0.5 pM and demonstrates negative cooperativity effects. It is predominantly membrane bound and probably corresponds to the Mr = 200,000 protein isolated by ...
305
Cyclic Nucleotide induced Maturation of Human Promyelocytic Leukemia Cells
... morphologically. Formyl-peptide receptor expression was the earliest marker of these modified programs of maturation. The receptor appeared within 2 h after treatment and increased linearly for 72 h. Receptor ...
13
Molecular Mechanisms of a Retinal Cyclic Nucleotide-Gated Channel
... manner (Sun et al., 1996; Flynn and Zagotta, 2001; Contreras and Holmgren, 2006). Again, these latter studies are in direct opposition with the location of the gate in the S6 segment, as shown in Kv channels using a ...
165
Excitation contraction coupling in the rat anococcygeus muscle
... that cyclic nucleotide changes occur in many different cellular compartments, only one of which is important in the regulation of ...the cyclic nucleotide ratio in all of the compartments are ...
212
Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin
... of cyclic AMP accumulation was inhibited 75--80% by the prostacyclin synthetase inhibitors 12-hydroperoxyeicosatetraenoic acid or 9,11-azoprosta-5,13-dienoic ...stimulated cyclic AMP accumulation in the ...
8
The role of cyclic nucleotides and cyclic nucleotide phosphodiesterase in development of Mysococcus santus analysis of mutants.
... aggregation or sporulatwn. Type II strains were able to aggregate but did not spbrulate, A strain classed as a Type III strain was a low capacity fruiter. r Each category displayed defects in cyclic ...
59
The 3'-terminal nucleotide sequences of adenovirus types 2 and 5 DNA.
... The reaction mixture was incubated at 11 C for was Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Short nucleotide sequences at the 3'-termini of adenovirus types 2 an[r] ...
5
Adenyl cyclases and cAMP in plant signaling - past and present
... 1970s, 3'-5'-cyclic adenosine monophosphate (cAMP) had been firmly established as an important sig- naling molecule and second messenger in both animals and lower eukaryotes ...of cyclic AMP in ...
5
Cyclic Association Rules Mining under Constraints
... the cyclic association rules generated ...of cyclic association rules[5]; (ii) the contribution of Thuan [6] and revisited [7,8], (iii) the method introduced by Ben Ahmed and Gouider ...
8