24,25-dihydroxyvitamin D3
Vitamin D dependent rickets type II Defective induction of 25 hydroxyvitamin D3 24 hydroxylase by 1,25 dihydroxyvitamin D3 in cultured skin fibroblasts
... 1,25(OH)2D or vitamin D-dependent rickets type II (DD II). Fibroblasts were preincubated with varying concentrations of 1,25(OH)2D3 for 15 h and were then incubated with 0.5 microM [3H]25(OH)D3 at 37 ...
8
Effects of I ,25-Dihydroxyvitamin-D3 on Renal Function, Mineral Balance, and Growth in Children with Severe Chronic Renal Failure
... 24,25-dihydroxyvitamin-D3 secretion, especially in relation to phosphorus,44’45 is being investigated by various laboratories.46’47 The role of hyperphospha- temia in suppressing serum c[r] ...
15
Impaired stimulation of 25 hydroxyvitamin D 24 hydroxylase in fibroblasts from a patient with vitamin D dependent rickets, type II A form of receptor positive resistance to 1,25 dihydroxyvitamin D3
... detection of 1,25-(OH)2D3 action in normal skin fibroblasts. Following treatment of normal cell monolayers with 1,25-(OH)2D3 there was more than a 20-fold increase of 25-hydroxy- vitamin D-24-hydroxylase ...
11
1,25 Dihydroxyvitamin D3 production by human keratinocytes Kinetics and regulation
... parathyroid hormone(1-34) and isobutylmethylxanthine are added. Exogenously added 1,25(OH)2D3 at concentrations as low as 10(-12) M reduces endogenous 1,25(OH)2D3 production, increases 1,25(OH)2D3 catabolism, and ...
11
The effects of 1α,25 dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion
... Prostaglandins are primary mediators of inflammation and have important roles in the immune response and the inflammatory processes associated with rheumatoid arthri- tis, and PGE 2 has been implicated in the ...
8
25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression
... Early human studies described skeletal muscle morphological changes consisting of non- specific/type II fast-twitch fiber atrophy and degeneration, that were reversible with vitamin D supplementation in patients with ...
20
1 alpha,25 dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells
... dihydroxyvitamin D3 (24,25-(OH)2-D3) had a similar inhibitory effect. 1,25-(OH)2-D3 was not cytotoxic and did not affect unactivated ...1,25-(OH)2- D3 is a potent inhibitor of human PBM ...
6
Optimal bone fracture repair requires 24R,25 dihydroxyvitamin D3 and its effector molecule FAM57B2
... the 24-hydroxylated metabolite 24R,25(OH) 2 D 3 (15, 16), as preincubation with either 25(OH)D 3 ; 1,25(OH) 2 D 3 ; 1,24,25(OH) 3 D 3 ; or the non-natural epimer 24S,25(OH) 2 D 3 (15, 16) was ...
13
Chronic 1,25 dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25 hydroxyvitamin D by increasing metabolic clearance rate
... of 25-OH-D to 24,25(OH)2D3 by kidney homogenates. The reduction in serum 25-OH-D3 was completely accounted for by an increase in ...serum 25-OH-D3 and 24,25(OH)2D3 was shown not to be ...
8
Enterohepatic physiology of 1,25 dihydroxyvitamin D3
... within 24 h. The process by which products of 1,25-dihydroxyvitamin D3 were excreted in bile was not saturable in the dose range tested ...1,25-dihydroxyvitamin D3 present in bile were ...
9
Regulation of 1,25 dihydroxyvitamin D3 receptor gene expression by 1,25 dihydroxyvitamin D3 in the parathyroid in vivo
... 1,25(OH)2D receptor (VDR) in the parathyroid in vivo. Rats were injected with 1,25(OH)2D3 and the parathyroid-thyroid tissue analyzed for PTHmRNA and VDRmRNA. 1,25(OH)2D3 (50 and 100 pmol ip) decreased PTHmRNA at 6 h ...
9
Hyperresponsiveness of vitamin D receptor gene expression to 1,25 dihydroxyvitamin D3 A new characteristic of genetic hypercalciuric stone forming rats
... Animals and diets. A colony of GHS rats was created by mating spontaneously hypercalciuric male and female Sprague-Dawley rats (18, 28, 29). Classification of rats as hypercalciuric was done at com- pletion of weaning, ...
11
1,25 Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels
... trisphosphate (IP3). Treatment of keratinocytes for 24 h with 1 nM 1,25(OH)2D3 resulted in a two- to four-fold potentiation of the Cai response of these cells to ATP. This potentiation was inhibitable with ...
9
Effect of age on the conversion of 25 hydroxyvitamin D3 to 1,25 dihydroxyvitamin D3 by kidney of rat
... dihydroxyvitamin D3 after 24 h compared with ...tritiated 25-hydroxyvitamin D3 to its products was also measured directly in isolated slices of renal ...1,25-Dihydroxyvitamin ...
7
The Influence of 1α.25-Dihydroxyvitamin D3 Coating on Implant Osseointegration in the Rabbit Tibia
... based on a previous in vitro investigation [18]. 1.25-(OH) 2 D 3 was diluted in ≥ 99.5% ethanol until desired concentrations were achieved. The implants were soaked in the respective solution for 1 h and thereafter were ...
8
Renal Hypophosphatemic Rickets: Growth Acceleration After Long-Term Treatment with 1,25-Dihydroxyvitamin-D3
... Treatment with 1,25-dihydroxyvitamin-D3 and phosphorus supplementation for as long as 48 months was evaluated in six patients with renal hypophospha-.. temic rickets.[r] ...
12
Ligation of TLR9 induced on human IL 10–secreting Tregs by 1α,25 dihydroxyvitamin D3 abrogates regulatory function
... however its functional relevance remains unclear. Here we have shown that TLR9 is highly expressed by human Treg secreting the antiinflammatory cytokine IL-10 induced following stimulation of blood and tissue CD3 + T ...
13
Decreased 1,25 dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients
... 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in uremic hyperparathyroidism is thought to be caused, in part, by a 1,25(OH)2D3 receptor (VDR) deficiency in the ...
9
1, 25 Dihydroxyvitamin D3 Protects the Heart Against Pressure Overload-induced Hypertrophy without Affecting SIRT1 mRNA Level
... 1, 25-dihydroxyvitamin D on the hypertrophic markers and cardiac level of SIRT1 mRNA in rats following the aortic ...1,25 dihydroxyvitamin D3 (H+VD), rats received propyleneglycol as a vitamin ...
10
Ameloblasts and odontoblasts, target cells for 1,25 dihydroxyvitamin D3: a review
... Int I De, Bioi 39; 257 262 (1995) Ameloblasts and odontoblasts, target cells for 1,25 dihydroxyvitamin D3 a review ARIANE BERDAL', PETROS PAPAGERAKIS, DOMINIQUE HaTTON, ISABELLE BAILLEUL FORESTIER, JE[.] ...
6