3′ splice site
Selective Inhibition of Splicing at the Avian Sarcoma Virussrc 3′ Splice Site by Direct-Repeat Posttranscriptionalcis Elements
... in splice sites are consistent with the interaction of HIV-1 Rev with the spliceosomal machinery (11, ...src 3⬘ splice site is inhibited by the UDR will require isolation of the pu- tative ...
11
Utilization of the Bovine Papillomavirus Type 1 Late-Stage-Specific Nucleotide 3605 3′ Splice Site Is Modulated by a Novel Exonic Bipartite Regulator but Not by an Intronic Purine-Rich Element
... cryptic splice site further ...3605 3⬘ splice site BP in the BPV-1 late ...3225 3⬘ splice site-containing pre-mRNA or in Drosophila dsx pre-mRNAs showed that this ...
11
Interaction between the Negative Regulator of Splicing Element and a 3′ Splice Site: Requirement for U1 Small Nuclear Ribonucleoprotein and the 3′ Splice Site Branch Point/Pyrimidine Tract
... U2-dependent 3 * splice ...adenovirus 3 * splice ...the 3 * splice site, and it was sensitive to a mutation that was previously shown to abolish U11 snRNP binding and NRS ...
7
Mutagenesis of the Yeast Gene PRP8 Reveals Domains Governing the Specificity and Fidelity of 3′ Splice Site Selection
... These alleles suppress point mutations in the PyAG motif at the 3' splice site and do not alter uridine tract recognition.. The strongest of these alleles map to a r[r] ...
17
Function of a Bovine Papillomavirus Type 1 Exonic Splicing Suppressor Requires a Suboptimal Upstream 3′ Splice Site
... alternative 3 * splice sites at nucleotide (nt) 3225 and nt ...3225 3 * splice ...AG-rich 3 * end ...the 3 * splice site in the BPV-1 late pre-mRNA, Rous sarcoma ...
8
Congenital hypothyroidism due to mutations in the sodium/iodide symporter Identification of a nonsense mutation producing a downstream cryptic 3' splice site
... at 2 h, 2% at 4 h, and , 1% at 6 and 24 h). Scanning showed faint vi- sualization of both thyroid lobes, with possible reduction of activity in the right lower pole. Ultrasound displayed a very heteroechogenic thyroid ...
9
A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism
... A case of congenital goiter with defective thyroglobulin synthesis has been studied in molecular terms. The patient is the fifth of a kindred of six, three of which have a goiter. The parents are first cousins. ...
6
A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing
... the 3⬘ end of the Friend MuLV se- ...5⬘ splice site that is implicated in MuLV-driven rearrangements of the c-myb proto-oncogene (15, ...alternative splice donor site mentioned above, ...
6
New chimeric splice junction in adenovirus type 2-simian virus 40 hybrid viral mRNA.
... It contained an RNA splice junction which extended from a donor 5' nucleotide within the adenoviral RNA sequences to an acceptor 3' splice site within the early region of SV40 at 0.46 SV[r] ...
9
The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts.
... Transcripts from two of the mutants with precise deletions of the 19S introns were processed to 16S RNA species by utilization of the normal 16S 3' splice site and one of two 5' splice s[r] ...
9
Messenger RNA reprogramming by spliceosome mediated RNA trans splicing
... 5′ splice site domain can trans-splice to a 3′ splice site in the target pre-mRNA (ii in Figure 5); a PTM with a 3 ′ splice site domain can ...
8
Splice site skipping in polyomavirus late pre-mRNA processing.
... Since the VP1' exon retains only 81 nt deriving from the wild-type VP1 exon [14 nt adjacent to the VP1 3' splice site and 67 nt just upstream of the polyA site], exon skipping is not lik[r] ...
8
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2 dependent introns
... Browser site [22] we obtained spliced alignments of human ESTs (file ...ported 3' splice sites to identify 3-nt splice variant pairs ...minor splice variant did not exceed the ...
11
Correction of ClC 1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy
... conductance of chloride ions in the sarcolemma. However, the mechanistic basis of the chloride channelopathy and its relationship to the development of myotonia are uncertain. Here we show that a morpholino antisense ...
7
Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron.
... Further analysis showed that these RNAs were a completely unspliced env mRNA and an RNA in which an intron between the 3-globin 5' splice site and the tat/rev 3' splice site had been rem[r] ...
8
Transforming viruses spontaneously arise from nontransforming reticuloendotheliosis virus strain T-derived viruses as a result of increased accumulation of spliced viral RNA.
... Thus, a transition and deletion in CM135 3' of the 5' splice site used by Rev-T and an insertion in CM136 5' of the 3' splice site used by Rev-T were sufficient to convert a nontransform[r] ...
8
Simian virus 40 late mRNA leader sequences involved in augmenting mRNA accumulation via multiple mechanisms, including increased polyadenylation efficiency.
... These studies showed that addition of sequences which contain the late leader 3' splice site to the late promoter led to an increase in the accumulation of mRNA expressed by the promoter[r] ...
9
Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1.
... A highly sensitive assay for 5' splice site usage was designed by engineering an ACTl-CUP1 construct with duplicated 5' splice sites; mutations were introduced into[r] ...
13
Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.
... Its LTR comprises U3 derived from PR-C virus, whereas R and U5 are derived from endogenous virus; the splice donor site of viral leader RNA is linked directly to the splice acceptor site[r] ...
12
Transcriptome-Wide Analysis Of Hypoxic Cancer Cells Identify Alternative Splicing As A Mechanism To Inhibit Translation
... compared to other transcripts of NEK6. Likewise, splicing of MXI1 is directly influenced by HIF-binding, which impacts alternative promoter usage in this gene (84). Splicing is differentially regulated in cancer due to a ...
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