3-THIAZOLIDIN-4-ONE
DESIGN, SYNTHESIS AND IN SILICO STUDY OF NOVEL SERIES OF 2 PHENYL 3 (5 SULFANYL 1,3,4 THIADIAZOL 2 YL) 1,3 THIAZOLIDIN 4 ONE DERIVATIVES WITH POTENTIAL ANTI TUBERCULAR ACTIVITY
... 2-phenyl- 3-(5- sulfanyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one derivatives were synthesized by convenient one-pot three-component reaction of amine, aldehyde and mercaptoacetic ...
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Thiazolidinone as a pharmacologically active molecule
... V. Murugesan et al. performed comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) based 3D QSAR study of 2,3-diaryl-1,3-thiazolidin-4-one ...
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Journal of Applied Pharmaceutical Science
... 1,3-thiazolidin-4- one derivatives and their in vitro antibacterial ...1,3-thiazolidin- 4-one derivatives with an ethylester moiety at position 5 (compounds 4a and 4c) are good ...
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SYNTHESIS AND IN VITRO ANTIOXIDANT, ANTI INFLAMMATORY ACTIVITY OF THIAZOLYL THIAZOLIDIN 4 ONE DERIVATIVES
... 2-(4-chlorophenyl)-3-(4-phenyl-4,5-dihydro-1,3-thiazole-2-yl)-1,3-thiazolidin-4-one (2e) White solid; M.P. 204-206ºC; Yield: 78%; λmax= 309.40; IR (KBR) cm-1: 3354 (broad trough ...
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ANTI BACTERIAL ACTIVITY OF 3 (4 ARYL SUBSTITUTED 3 – YL) – THIAZOLIDIN 4 – ONE AND THEIR DERIVATIVES
... RESULTS AND DISCUSSION: Based on the literature review an attempt was made to synthesize some thiazolidin-4-one compounds by microwave oven. The antibacterial screening of the synthesized compounds ...
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Synthesis and Characterization of 2-imino-3–(2-Hydroxylphenyl)-1-Thiazolidin-4-one Substituted Ammine Complexes of Cr(III), Co(III), Ni(II) and Cu(II)
... As regards chelation through 2-imino-3– (2-hydroxylphenyl)-1-thiazolidin-4-one ligand, IR spectra exhibit significant features in υ O-H (phenolic) and υ C-N-C (heterocyclic’s) regions. The ...
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Hyperglycedemia and hypertriglyceridemia activities of newly synthesized compounds derived from 3'-(4-halophenyl)-5'-arylidene spiro(cyclohexane- (1,2')-thiazolidin)-4'-one
... form 3'-(4-halophenyl)-7'-(4-halo- or 4- methyl-phenyl)-5'-mercapto-3a',7a'-dihydro-3'H-spiro [cy-clohexane-1,2'- thiazolo [4,5-d] pyrimidin]-7a'-ol (14a-c), respectively (Scheme ...
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Antiinflammatory, analgesic and antipyretic activity of certain thiazolidinones
... for thiazolidin-4-one derivatives tested in the present study for having action similar to ...OCH 3 , NO 2 and OH in the aromatic ring resulted in increased activity as compared to ...
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DESIGN, SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED 3-(BENZOTHIAZOLE)-2-(PHENYL)-THIAZOLIDIN-4-ONE HETEROCYCLIC COMPOUNDS AND ITS BIOLOGICAL EVALUATION
... The test organisms (Aspergillus flavus and Candida albicans) were sub- cultured using potato dextrose agar medium. The tubes containing sterilized medium were inoculated with test fungi and after incubation at 25 °C for ...
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Synthesis and Characterization of the Thiazolidinone and/or Thiourea substituted Amine Complexes of Cu (II)
... Mixed ligand complexes of copper (II), involving either Mercaptyl thiazolidinone (1) [2-(2- hydroxy benzoyl)-3-N-(2-mercaptyl)-1-Thiazolidin-4-one] or Pyridine thiazolidinone (2) [ 2-(2- ...
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Synthesis, characterization and antimicrobial activity of some novel 2,3 disubstituted thiazolidin 4 one derivatives
... The several thiazole and thiazolidinone derivatives have been shown to exhibit excellent medicinal property. Thiazolidinones possessing antibacterial[1], anti-tubercular[2], antithyroid and amoebicidal[3]activity, ...
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MICROWAVE ASSISTED SYNTHESIS OF SOME NEW THIAZOLIDIN 4 ONE DERIVATIVES CONTAINING A PYRIMIDONE AND QUINOLINE MOITIES
... on thiazolidin-4- one derivatives I am reporting the synthesis 6-Methyl-2-oxo/thioxo-4-(substituted) phenyl-1, 2, 3, 4-tetrahydro-pyrimidine-5-carboxylic acid ...
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DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL 2 (5 (1H INDOL 3 YL) 1, 3, 4 THIADIAZOL 2 YLIMINO) 5 (SUBSTITUTED BENZYLIDENE) THIAZOLIDIN 4 ONE ANALOGUES
... -1, 3, 4- thiadiazol -2- ylimino) thiazolidin -4 -one (6): Indole- (1, 3, 4-thiadiazol-2-yl) -2-chloroacetamide ...for 3 h, the product obtained was filtered and ...
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THIAZOLIDIN-4-ONE DERIVATIVES ON HUMAN LUNG FIBROBLAST SHOWS OXYGEN FREE RADICAL SCAVENGING ACTIVITY
... To a constantly stirred solution of malononitrile (0.5 g, 0.00757 mol.) in 10.0 mL of ethanol, an appropriately substituted aromatic/heteroaromatic aldehyde (4a-l; 0.00757 mol) and 2-4 drops of pyridine was slowly ...
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Antitumor effect of 4-(N,N- dimethyl)-3-(3-Mercapto-5-Phenyl [1,2,4] triazol-4yl)- thiazolidin-4-one in liver carcinoma cell lines Hep G2 by (HCS) technique
... 8. George S., Pokhrel S., Xia T., et al., (2010) Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano , 4:15–29. 9. Abraham V.C., Towne D.L., ...
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AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN 2 YL THIAZOLIDIN 4 ONES
... novel 3-(5-methyl-1- phenyl- 1H-1,2,3-triazol-4-yl)- 6-aryl- 7H- [1, 2, 4] triazolo[3,4b] [1,3,4] thiadiazine derivatives 27 shown antibacterial activity against four human pathogenic bacteria ...
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SYNTHESIS AND ANTIMICROBIAL POTENTIAL OF THIAZOLIDIN-4-ONE DERIVATIVES
... All the synthesized derivatives were subjected to antimicrobial screening against Gram negative E. Coli, Gram positive bacteria: B. Subtilis, S. aureus, and fungal strains: A. niger. and C. albicans. by zone of ...
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Synthesis of novel Sultams containing thiazolidin 4 one heterocycles
... 3-(2-(1,1-dioxido-1,2-thiazetidin-2-yl)ethyl)-2-(4-nitrophenyl)thiazolidin-4-one 8(f) : yield, 55%; m.p: 215-1 0 C IR (KBr) pellets reflect the molecular structure and showed the ...
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Synthesis, Characterization and Study of Liquid Crystalline Behavior of New Compounds Containing Thiazolidin-4-one, 1, 2, 3-Triazole and Benzimidazol Rings
... Synthesis of 1,1-((1,3 Phenylenebis (Azanediyl)) Bis (2-Oxoethane-2,1- diyl))Bis(4,5-Dihydro-1H-1,2,3-Triazole-4- Carbonyl Chloride) [VI] and 1,1- ((1,3 Phenylenebis (Azanediyl)) Bis (2- Oxoethane-2,1-diyl)) Bis ...
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Synthesis of 5-arylidine-2-(3, 4, 5-trimethoxyphenyl)-3-(4-phenylthiazol-2-yl) Thiazolidin-4-one Derivatives as a Novel Class of Antimicrobial Agents
... of 4~thiazilidinone, we found that thiazole is a versatile motif comprising biocidal unit (S~C=N) which is easily metabolised inside the body and is already been a parent structure in many synthetic drugs that ...
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