3xTg-AD mice
Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology
... (3xTg-AD) mice. Brain sections of mice aged 18 months (c and d) and 20 months (a, b, e – h) were stained with a NeuN antibody (red) to detect neurons and an anti-A β antibody (McSA1, brown) to ...
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Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection
... during AD and to be activated following immune chal- lenge outside of the CNS ...In 3xTg-AD mice, infec- tion with the mouse hepatitis virus by intracranial injection increased levels of ...
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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
... control 3xTg-AD mice ...in mice treated with PLX5622 for 3 months. Mice were first tested on the Morris water maze, another hippocampal-dependent task that tests learning and mem- ory ...
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IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology
... in AD was initially motivated by the hy- pothesis that it contains natural, polyclonal, conformation- specific antibodies against ...of AD patients compared to controls ...treated mice, consistent ...
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Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
... the 3xTg-AD ...APPswe mice [37], suggesting that disruption of cellular membrane homeostasis could also contribute to inflam- matory molecule induction, and perhaps, regional differ- ences in lipid ...
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Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
... including AD, PD, stroke and head trauma ...of AD patients by as much as 25-fold [43], in line with substan- tial elevations in TNF- α synthesis that were rapidly induced in RAW ...develop AD suggest ...
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Neuroprotective effects of CD4 CD25 Foxp3 regulatory T cells in a 3xTg-AD Alzheimer’s disease model
... into 3xTg-AD transgenic mice to ameliorate Alzheimer-like ...of 3xTg-AD mice but also contributed to the reduced cerebral Aβ burden and decreased inflammatory cytokine ...the ...
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GLP 1/GIP/Gcg三受体激动剂改善3xTg AD小鼠认知行为和病理特征研究
... of AD, and some drugs used for treatment of T2DM have been applied as a novel therapeutic strategy for ...triple-transgenic AD mice (3×Tg-AD) by using behavioral tests, immunofluorescence ...
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Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model
... of AD, as it is well established that their amount correlates with the disease staging in the AD brain [30] as well as in the 3xTg-AD model ...in 3xTg-AD mice, we ...
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Exercise and resveratrol increase fracture resistance in the 3xTg AD mouse model of Alzheimer’s disease
... the 3xTg-AD mice for a period of four ...to AD controls. 3xTg-AD mice treated with these modal- ities have three-point bending test results within the range of those of ...
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Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
... Examination of the data evaluated via mixed (repeated measures) model ANOVAs revealed no violations of any assumptions that would warrant using a statistical test other than the ones described. Assumptions were tested ...
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Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
... in AD pathological cascade of events is rather ...in AD versus age-matched controls might be reconsidered in this ...in AD autoptic brain ...mild AD were selected [49], meanwhile it decreased ...
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Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse model
... transgenic AD mice could be used as a marker of drug efficacy for mem- ory ...transgenic AD models, APP/PS1 [13] and 3xTg-AD [14], the presence of spike-wave discharges (SWDs) correlate ...
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Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease
... Many epidemiological and functional neuroimaging [62] studies have shown that the dysregulation of energy metabolism in the brain is a significant causative factor in the development of dementia. Positron emission tom- ...
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Abundance of Aβ5-xlike immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease
... Alzheimer’s disease (AD) is the most common type of de- mentia worldwide. It is characterized by the accumulation of specific proteins, namely tau and amyloid-beta protein (Aβ). In fact, these proteins are ...
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Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice
... the AD phenotype in 5X familial mice [57], few studies demonstrated the direct effect of inhibition of ERK activity in the AD ...the AD brain from neuroinflammation and sub- sequent ...
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Distinct Roles of Adenovirus Vector-Transduced Dendritic Cells, Myoblasts, and Endothelial Cells in Mediating an Immune Response against a Transgene Product
... Efficiencies of adenoviral vector infections in distinct cell types. In order to analyze the infectibilities of the distinct cell types present in muscle, EC, myoblasts, and DC were infected with an AdGal vector ...
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Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
... TLR4w AD mice. The role of IL-17 in the pathogenesis of AD remains to be ...TLR4m AD mice at 14–16 months of age showed an increase in fibrillar Aβ deposits compared to TLR4w ...
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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model
... transgenic mice (3 months) were decapitated, forebrains rapidly removed and placed in ice-cold mannitol-sucrose (MS) buffer pH 7.4 (225 mM mannitol, 75 mM sucrose, 5 mM Hepes, 1 mg/ml fatty acid free BSA (Roche ...
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The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
... huAPP/PS1 mice follow- ing seven months of treatment, and here we show that even when administered at a stage when pathology is advanced, J147 can significantly increase two factors criti- cal for memory ...
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