4-1BB
PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody
... or 4-1BB antibody (cata- log #MAB9371, clone #158321, R&D Systems; Minneap- olis, MN) was dosed ranging from 1 mg/kg to ...and 4 T1 tumors on the left ...
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Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation
... the 4-1BB receptor-ligand system in viral infection control is further supported by the fact that 4-1BB ligand-deficient mice exhibit impaired im- munity against lymphocytic choriomeningitis ...
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A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
... Chimeric antigen receptor (CAR)-expressing T cells are a promising therapeutic option for patients with cancer. We developed a new CAR directed against the disialoganglioside GD2, a surface molecule expressed in ...
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Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer
... anti-4-1BB augmented therapeutic efficacy of adoptively transferred TDLN cells, hence demonstrating an important role played by host NK cells in the combined therapy with T cell transfer plus ...
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Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
... In order to generate CD166 CAR-expressed T cells in vitro, we first constructed the lentivirus vectors contain- ing the sequence encoding the anti-CD166 scFv. The CD166-directed CAR expression was composed of an ...
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Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody
... cells (express CD45.2) were inoculated to CByJ.SJL(B6)-Ptprca/J (CD45.1 BALB/C) mice. Recipient mice were treated with SV-GFP 4 days later. GFP expression was measured the next day. Figure S2. SV infection ...
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Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice
... Although 4-1BB was originally described as a surface molecule present on leukocytes, recent studies have revealed that it is expressed in inflamed blood vessels, hypoxic endothelial cells and even ...
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Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation
... and 4-1BB or CD28 and OX40, with CD28 placed proximal to the cell membrane ...and 4-1BB ...and 4-1BB in a third-generation CAR showed enhanced antitumor effects and synergistic ...
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Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients
... with 4-1BBL exhibited increased persistence and anti- tumor activity in vivo ...and 4-1BB could ameliorate exhaustion by reducing the expression of known exhaustion-related genes and by modulating ...
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<p>Combination of CpG Oligodeoxynucleotide and Anti-4-1BB Antibody in the Treatment of Multiple Hepatocellular Carcinoma in Mice</p>
... anti- 4-1BB antibody into the tumor, the tumor growth rate at the injected drug site slowed, and the indicators were improved compared with those of the model ...while 4-1BB group had only a ...
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Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol
... or 4-1BB domains, and these 2nd-G CAR-T cells have achieved promising results in patients with ...or 4-1BB co-receptors have different in fl uence on the metabolic characteristics of CAR-T ...
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According to Hepatitis C Virus (HCV) Infection Stage, Interleukin-7 Plus 4-1BB Triggering Alone or Combined with PD-1 Blockade Increases TRAF1low HCV-Specific CD8+ Cell Reactivity
... infection, these cells are functionally impaired, which could be due to the failure of costimulation. This study describes exhausted specific T cells, characterized by low levels of expression of the signal transducer ...
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Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle
... used 4-1BB-deficient obese mice fed an HFD to investigate whether the 4-1BBL and 4-1BB system, another member of the TNF-TNFR superfamily, participates in obesity-induced skeletal ...
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4-1BB enhancement of CAR T function requires NF-κB and TRAFs
... mutated 4-1BB endodomain (mut01–mut04) to modulate NF-κB signaling. The 4-1BB endodo- main mutants were located in previously identified (29, 30, 32, 33) TRAF1–3 binding ...double ...
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Multivalent 4 1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice
... Aptamers correspond to a new class of therapeutic agents that offer important advantages over Abs to manipulate the immune sys- tem for therapeutic purposes. Abs are cell-based products requiring a complex and costly ...
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1-s2.0-S2372770519300324-main.pdf
... or 4-1BB-derived CSSD, which are currently used for CAR-T cell development, we found that the CAR-T cells with a herpes virus entry mediator (HVEM)-derived CSSD exhibited enhanced effector functions and ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... targeting 4-1BB with an agon- ist antibody can promote tumor control in numerous pre- clinical models, and is often associated with increased CTL effector capability ...mammary 4 T1 tumors in mice ...
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Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
... In light of the therapeutic potential of NKG2D CAR T cells for TNBC and because of the potential for ex- pression of NKG2DLs on healthy tissues, the concerns about potential “on-target, off-tumor” toxicity must be ...
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PD 1 identifies the patient specific CD8+ tumor reactive repertoire infiltrating human tumors
... of 4-1BB in fresh ovarian TILs, Ye et ...of 4-1BB, but not PD-1, on lymphocytes defines the population of tumor-reactive cells in the tumor ...than 4-1BB more comprehensive- ly ...
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Recognition of human gastrointestinal cancer neoantigens by circulating PD 1+ lymphocytes
... and 4-1BB upregulation following cocul- ture of the enriched populations of neoantigen-reactive lympho- cytes and PBLs transduced with neoantigen-specific TCRs with the autologous tumor cell lines derived ...
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