4- naphthoquinone
Synthesis and biological evaluation of new amino derivatives of 1,4 naphthoquinone
... The amino acid derivatives of 1,4-naphthoquinone (1-3), with aliphatic amino acids which do not contain side chains, were chosen for the synthesis of chlorides, thus was reduced the probability of occurrence of ...
8
Synthesis and characteristics of amino acid derivatives of 1,4 naphthoquinone
... that naphthoquinone derivatives with substituted chlorine atom exhibit some activity against fungi ...N-1,4- naphthoquinone derivatives are characterized by moderate toxicity ...
6
Vibrational study on the molecular structure of 1,4 naphthoquinone and 2 methyl 1,4 naphthoquinone and their radical anions by using density functional theory
... The quinones and their radical anion intermediates are important in understanding their functions in various chemical and biological processes involving redox reactions processes and also because of their potential ...
26
Loach embryos prooxidant-antioxidant status under the influence of amide derivatives of 1,4-naphthoquinone
... derivatives to penetrate pervitelline space and blas- tomeres plasma membrane. Amide derivatives of 1,4-naphthoquinone (FO-1, FO-2) cause damage to integrity of the cytoplasm membrane, the release of intracellular ...
8
In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2 aniline 3 hydroxy 1 4 naphthoquinone derivatives
... nanomolar order of magnitude. This high anti-malarial activity is probably due to the instability of the radical trifluormethylbenzene, which leads to the formation of free radicals that are toxic to the parasite [11]. ...
11
Yttrium Selective Poly(Vinyl) Chloride Sensor Based on Derivative of 2-Amino-1,4-Naphthoquinone
... The ligand (ionophores H) based on 2-amino-1,4-naphthoquinone have been synthesized and explored as neutral ionophores for preparing polyvinyl chloride-based membrane sensor for the determination of yttrium(III). ...
13
DESIGN, SYNTHESIS, AND EVALUATION OF 1,4 NAPHTHOQUINONE DERIVATIVES AS POTENTIAL EPITHELIAL GROWTH FACTOR RECEPTOR INHIBITORS
... including, 4- (phenylamino) pyrimido[5,4-d] pyrimidines, 4- (phenylamino) pyrrolo[2,3-d] pyrimidines, 4- (phenylamino) quinazolines, and 4-[ar(alk) ylamino] pyrido [4,3-d] pyrimidines 18 ...
11
Vibrational study on the molecular structure of Zin c Juglonate [Zn(5 hydroxy 1, 4 naphthoquinone) 2 ] by DFT and HF calculations
... Zinc -Juglonate (5-hydroxy 1, 4-naphthoquinone) was synthesized. The vibrational wave numbers of chelate have been calculated using Gaussian 09 software code, employing RHF / SDD basis set and DFT / B3LYP/ ...
8
Synthesis, Characterization, Molecular Docking Studies of Substituted 2-Amino 3-Chloro Naphthoquinone Derivatives and their Pharmacological Assessment
... 5. Silva et al., (2013) studied the “Synthesis of 2, 3-diyne-1, 4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines”. This study described a synthesize of a series of ...
99
Bactericidal and Bacteriostatic Activity of Isolated Naphthoquinone Fraction of Lawsonia Inermis and Synthetic Lawsone on Staphylococcus Epiderm
... (2-hydroxy-1, 4- ...of naphthoquinone fraction in view of isolation of lawsone from Lawsonia inermis was done by soxhlet extraction method and yield was found to be ...Isolated naphthoquinone ...
8
OXIDATIVE DEHYDROGENATION OF 1-TETRALONES: SYNTHESIS OF JUGLONE, NAPHTHAZARIN, AND ?-HYDROXYANTHRAQUINONES
... Treatment of 5,8-dihydroxy-1-tetralone (9) with either 2,3-dichloro-5,6- dicyano-1,4-benzoquinone (DDQ) in refluxing benzene or silver (I) oxide in refluxing 1,4-dioxane afforded juglone ...
9
DEVELOPMENT AND VALIDATION OF LC MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF QUINONES IN TECTONA GRANDIS LINN
... instrument. Shimadzu LCMS-8040 model (Triple Quadrupole Mass Spectrometer) was used for optimization of MRM transitions for 2-methylanthraquinone, 5-hydroxy-1,4- naphthoquinone, 2-(hydroxymethyl) anthraquinone and ...
10
Journal of Applied Pharmaceutical Science
... Protein Kinase C (PKC) is widely documented to be involved in the regulation of cancer cell growth, proliferation, survival, inflammation and apoptosis. This study evaluates the capability of 2-Methoxy-1,4- ...
5
Synthesis, compositional and spectral studies of some transition metal complexes with 3-aminolawsonoxime
... there has been growing interest in the structural study of the complexes derived from organic compounds containing oxygen and nitrogen donors with antimicrobial activity. Quinones are the naturally occurring materials in ...
7
Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA
... that naphthoquinone plumbagin is able to inhibit invasion and migration of malignant cells, especially by inhibition of metalloproteinase-2 and urokinase-plasminogen activator ...
18
Synthesis of Some New Bisindole Derivatives and Their Biological Activity
... Substituted 1,4-diaza-1,3-butadienes with 2 equivalents of 1,4-naphthoquinone in presence of ethanol or benzene produce corresponding substituted bisindoletetrones via criss-cross cycloaddition reaction. The ...
6
Vol 4, No 10-12 (2015)
... Treatment of 1,4-naphthoquinone 3 with indole in the presence of 2 mol % of TfOH at room temperature gave 2- (3-indolyl)-1,4-naphtoquinone 3a in 55 % yield. All the reactions of indoles a-d with ...
5
Synthesis and Antimicrobial Activity of 1,4-Naphthoquinones Derivatives with [1,2,4]-Triazole-3-thione Substitution
... during 4 h highest yields were detected using as a base K 2 CO 3 ...product 4 (78%) was received using Et 3 N, at 80° in toluene during 4 ...substitution 4, 6 to 2,3-dichloro-1 ...
5
Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles
... Abstract: Several reports have demonstrated the anticancer activities of plumbagin, a naphthoquinone derivative isolated from plants belonging to Plumbaginaceae family. However, to the best of our knowledge, there ...
10
Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis
... Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a quinone isolated from the roots of Plumbago zeylanica was recently reported to suppress the activation of NF- kappa B in tumor cells [1]. T cells and their ...
7