5-alpha reductase (type-2)
Testicular histological and immunohistochemical aspects in a post-pubertal patient with 5 alpha-reductase type 2 deficiency: case report and review of the literature in a perspective of evaluation of potential fertility of these patients
... patients 2, 9 and 10), presenting with clinical features resembling a 5α-R2 ...orchid 5 alpha-reductase type 2 deficiency patients ...in 5 alpha-reductase ...
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Molecular genetics of steroid 5 alpha reductase 2 deficiency
... the type 2 isozyme lead to male pseudohermaphroditism in which affected males have a normal internal urogenital tract but external genitalia resembling those of a ...The 5 ...
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The role of 5 alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme?
... by 5-alpha reductase (5-AR) enzymes types 1 and ...of 5-AR such as dutasteride and finasteride may therefore have an important role in the prevention and treat- ment of BPH and prostate ...
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Tissue distribution and ontogeny of steroid 5 alpha reductase isozyme expression
... The type 2 isozyme is transiently expressed in skin and scalp of ...newborns. Type 2 is the predominant isozyme detectable in fetal genital skin, male accessory sex glands, and in the ...
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High dose androgen therapy in male pseudohermaphroditism due to 5 alpha reductase deficiency and disorders of the androgen receptor
... have 5 alpha-reductase deficiency, and two have defects of the androgen receptor (the Reifenstein ...with 5 alpha-reductase deficiency and one man with the Reifenstein syndrome ...
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PIC50PRED: A PIC50 PREDICTION TOOL FOR 5 ALPHA REDUCTASE ENZYME
... 5-alpha reductase (5AR) is a promising target for prostate cancer. The enzyme is used in the irreversible conversion of testosterone to dihydrotestosterone (DHT). The concentration of DHT within the ...
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5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis
... steroid 5-alpha-reductases have been iden- tified, 5-alpha-reductase type I (SRD5A1) and 5-alpha- reductase type II (SRD5A2) ...described type ...
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Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors
... The pharmacophore model generated by considering 29 compounds, having activity against 5-alpha reductase. These compounds have significant structural properties mandatory for binding to the receptor ...
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A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits
... potential.5-alpha reductase inhibitors, such as finasteride and dutasteride, are becoming more commonly prescribed for women with hair ...and 5 mg ...
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Stabilization of Prostate Cancer with Amanita phalloides : Intervals with 5-Alpha-Reductase Inhibitors and Melatonin to Circumvent Resistance: Case Report Isolde Riede 1*
... Initially 50 ml of Amanita phalloides D2 were taken per year in 2010, in 2015 a dose of 50 ml is necessary per month to further stabilize the PSA level. Habituation of the cells is observed. Therefore the strategy of ...
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Impact of 5-Alpha Reductase Inhibitors Treatment for Benign Prostatic Hyperplasia on Erectile Dysfunction: A Meta-Analysis
... of 5-alpha reductase inhibitors treatment for BPH on erectile ...about 5-alpha reductase inhibitors therapy in BPH was performed among PubMed, EMBASE, Science Direct and The ...
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Genetic and pharmacological evidence for more than one human steroid 5 alpha reductase
... steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone, and impairment of this reaction causes a form of male pseudohermaphroditism in ...
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INDIAN HERBS THAT ACT AS 5-ALPHA REDUCTASE INHIBITORS
... called 5-alpha-reductase type II, which is required by the body to convert testosterone into DHT in the ...inhibiting 5-alpha-reductase type II as finasteride, the ...
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Role of 5 alpha-reductase inhibitors in the management of prostate cancer
... Abstract: Prostate cancer is one of the most complex and enigmatic oncologic problems in medicine. It is highly prevalent, particularly in elderly males. Unfortunately, its generally protracted and variable clinical ...
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<p>Integrative and Analytical Review of the 5-Alpha-Reductase Type 2 Deficiency Worldwide</p>
... -reductase type 2 de fi ciency is a rare condition with a worldwide distribution which needs to be considered as a diagnosis in front of all 46,XY newborn with atypical ...the 5 α - ...
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Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia
... within 2 years before the index date (n = 28) because some cancer treatments ...± 2 years), general practice attended, index date (same index date as the matched case), and start year in the CPRD ( ± ...
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Induction of a deficiency of steroid delta 4 5 alpha reductase activity in liver by a porphyrinogenic drug
... The hepatic enzymes that catalyze drug oxidations and the reductive metabolism of steroid hormones to 5alpha-derivatives are localized in membranes of the endoplasmic reticulum. Phenobarbital, which exacerbates acute ...
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Review Article Association between steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and prostate cancer risk: a meta-analysis study
... Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, In- gles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson ...
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SCREENING OF BIOACTIVE COMPOUNDS FROM LEAF OF CENCHRUS CILIARIS L FROM THAR REGION OF RAJASTHAN, INDIA
... . 2-Hexadecen-1-ol, 3, 7, 11, 15- tetramethyl-, [R- [R*, R*-(E)]]- and Phytol, acetate both are phenolic compounds in ...nature. 2-Methyltetracosane, also known as Isopentacosane belongs to the family of ...
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Underlying Genetic Defects in Diseases of Sexual Development in the Island of Cyprus Support the Founder Effect
... steroid reductase deficiency (5αsrd) is an autosomal recessive enzymatic deficiency that results from mutations in the 5α steroid reductase type 2 gene (srd5A2) that causes male ...
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