5-carbonitrile
One-pot three-component synthesis of pyrimidine-5-carbonitrile derivatives in water using p-dodecylbenzenesulfonic acid as catalyst and evaluation of in vitro anti-inflammatory and anthelmintic activities.
... The increasing importance of pyrimidines and their derivatives as intermediates for the synthesis of biologically and industrially useful compounds prompted us to synthesize pyrimidinecarbonitrile derivatives. Literature ...
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Synthesis of Novel 2-Butyl-1H-Benzo [4, 5] Imidazo [1, 2-A] Imidazo [4, 5-E] Pyridine-5-Carbonitrile Derivatives and Evaluation of Their Anticancer Activity
... A series of new 2-butyl-1H-benzo[4,5]imidazo[1,2-a]imidazo[4,5-e]pyridine-5-carbonitrile derivatives were synthesized by the self cyclisation of (E)-2-(1H-benzo[d]imidazol-2-yl)-3-(2-butyl- ...
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Synthesis, Crystal and Molecular Structure Studies and Hirshfeld Surface Analysis of a 6 amino 1,4 dihydro 3 methyl 4 (5,7 dimethyl 2 oxo 2Hchromen 4 yl)pyrano[2,3 c]pyrazole 5 carbonitrile
... 6-amino-1,4-dihydro-3-methyl-4-(5,7-dimethyl-2-oxo-2H-chromen-4-yl)pyrano[2,3-c]pyrazole-5- carbonitrile: The synthesis of 1,4-dihydropyrano[2,3-c]pyrazole compound was carried out via one-pot four ...
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SYNTHESIS AND ANTIOXIDANT ACTIVITY OF 6-IMINO-4-(METHYLTHIO)-2-(PYRIDINE-3-YL)-6H-1,3-THIAZINE-5-CARBONITRILE
... Synthesis of novel heterocyclic 6-imino-4-(methylthio)-2-(pyridin-3-yl)-6H-1,3-thiazine-5-carbonitrile (3) was prepared by condensing thionicotinamide (1) with bis(methylthio)methylene malononitrile (2) in ...
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SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY OF 4 THIAZOLIDINONE COMPOUNDS 1 (2,4 DINITROPHENYL) 4 (SUBSTITUTEDPHENYL) 6 [2 (4 CHLOROPHENYL) 4 OXO 1,3 THIAZOLIDIN 3 YL] 3 METHYL 1,4 DIHYDROPYRANO[2,3 C] PYRAZOLE 5 CARBONITRILE
... nitrophenyl)methylene]amino}-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile, thioglycolic acid and anhydrous zinc chloride in absolute ethanol were refluxed and then product obtained was ...
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Synthesis and characterization of 2 aminopyrimidine 5 carbonitrile derivatives and their antibiotic screening
... A solution of 1,2,3,4-tetrahydro-6-(4-fluorophenyl/4-bromophenyl/isobutyl)-4-oxo-2-thioxopyrimidine-5- carbonitrile(0.05mol) in DMF(70ml) was stirred for 3hr with potassium carbonate(0.1mol) and methyl ...
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EXPERIMENTAL AND DENSITY FUNCTIONAL THEORY INVESTIGATION OF BOND LENGTH, BOND ANGLE AND THERMODYNAMIC PARAMETERS IN DIHYDROPYRIMIDINE CARBONITRILE
... MAY-JUNE 2017, VOL- 4/31 www.srjis.com Page 5124 TABLE 3: Optimized bond angles of 1,2,3,4-tetrahydro-6-(3-nitrophenyl)-4-oxo-2- thioxopyrimidine-5-carbonitrile by DFT method at B3LYP level using 6-311++G ...
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Microwave Assisted Solid Phase Synthesis of Trisubstituted
... To synthesise 2,4-diaminopyrimidine-5-carbonitrile with 2% of BDDMA cross linked chloromethyl polystyrene resin having a chlorine loading capacity of 4.0 mmol/g as the solid support, at first, the N-C-N ...
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Journal of Applied Pharmaceutical Science
... Compounds 1a-c were allowed to react with phosphorus pentachloride and phosphorus oxychloride to give 4-chloro-6- (substituted)-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles 2a-c. Compounds 2a-c underwent variant ...
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Synthesis and characterization of novel 1,6-dihydropyrimidine derivatives for their pharmacological properties
... In the present work, synthesis of proposed compounds N′-(5-cyano-1-methyl-6-oxo-4-(thiophen-2-yl)-1,6- dihydropyrimidin-2-yl)substituted benzohydrazide (4a–d) and (E)-2-(2-substituted ...
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SYNTHESIS OF NOVEL PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES AND THEIR IN VITRO ANTIMICROBIAL AND CYTOTOXIC EVALUATION
... 4, 5-trimethoxyphenyl)-1, 4- dihydropyrimidine-5-carbonitrile (1) was prepared by refluxing an equimolar mixture of ethyl cyanoacetate, allyl thiourea and 3, 4, 5-trimethoxybenzaldehyde in ...
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Crystal Structure of 3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c] isoxazole-3a-carbonitrile
... was evaporated and purified by column chromatography (silica gel 60-120 mesh 7% EtOAc in hexanes) to provide the desired pure product 3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole-3a-carbonitrile a as ...
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Microwave Assisted Synthesis of Tri Substituted Pyridine 3 Carbonitrile Derivatives Using 3 Aminobut 2 Enenitrile
... 4,6-diphenlpyridine-3-carbonitriles 3 under conventional heating as well as microwave irradiation at different temperatures and time. After experimentation with different reaction temperatures and time, we found that the ...
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A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile
... Following the demonstration that both PCN and LCA activate classical target genes for PXR (PCN and LCA), FXR (LCA only) and VDR (LCA only), we next examined the total transcriptome response to these agents. Exposure of ...
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MW ASSISTED SYNTHESIS AND BIOLOGICAL PREDICTION STUDY OF SOME NEW PYRAZOLE 4 CARBONITRILE DERIVATIVES USING MALONONITRILE
... 3) The highest Pa value (0.907) for complement factor D inhibitor is being shown by 2- thiophen-2-ylmethylene-malononitrile (IIIa) while anaphylatoxin receptor antagonist activity (Pa=0.740) is being shown by ...
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One pot Multicomponent Synthesis of Some Pyridine 3 carbonitrile Derivatives and Their Biological Evaluation as Cytotoxic Agent
... incubated for further 4 h at 37∘C under 5% CO2. To stop the reaction and dissolve the formed crystals, 200 𝜇L of 10% sodium dodecyl sulphate (SDS) in deionized water was added to each well and incubated overnight ...
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DETERMINATION OF SOLUTE SOLUTE AND SOLUTE SOLVENT INTERACTIONS OF 2, 4 DIOXO PYRIMIDINE CARBONITRILE AND 4 OXO 2 THIOXO PYRIMIDINE CARBONITRILE IN 60% AQUEOUS DMSO AT 303 15 K
... Result And Discussion: The values of the densities, molar volumes, viscosities and relative viscosities of 2,4 dioxopyrimidine carbonitrile and 4-oxo-2-thioxo pyrimidine carbonitrile in 60 % aqueous DMSO ...
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A rapid and efficient route to synthesis of 2-amino-4H-pyran-3-carbonitrile derivatives in the presence of L-proline and their antimicrobial activity
... to 5 mol% the reaction time was shortened with higher yield (Table 4, entry ...from 5 mol% to 10 mol% reaction required prolonged heating with the low yield (Table 4, entry ...
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Synthesis, Crystal Structure, DFT studies, Docking Studies and Fluorescent Properties of 2-(Adamantan-1-yl)-2 H-isoindole-1-carbonitrile
... The atomic net charges of the DFT optimised structure are shown in figure 5. The two N-atoms have the highest electronegativity and showed the lowest net atomic charge values (N1 = -0.32 e and N2 = -0.19 e) within ...
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Vol 5, No 5 (2017)
... In all the previously mentioned applications, multilevel converters are as a rule progressively considered as a key innovation, subsequently of their ability to deal [r] ...
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