5-hydroxymethylcytosine
5 hydroxymethylcytosine profiling as an indicator of cellular state
... Figure 3. Proposed model of 5-methylcytosine, 5-hydroxymethylcytosine and TeT distribution associated with gene transcription. Activation of gene expression can occur through the active demethylation ...
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Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains
... expression. 5-hydroxymethylcytosine (5hmC) converted from 5-methylcytosine by the ten-eleven trans- location (TET) family of proteins has emerged as a new epigenetic ...in 5-methylcytosine ...
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5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin
... On this basis, our study aimed at investigating in two relevant cohorts of MPM the expression of 5-hydroxymethylcytosine (5- hmC), an epigenetic marker and an important regulator of embryonic ...
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Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia
... of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field of epigenetics, but information on the genome-wide distribution of 5hmC is ...
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TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma
... by 5′-cytosine methylation (5-methylcytosine ...converts 5-mC to 5-hydroxymethylcytosine ...decreased 5-hmC levels in various cancers, functions of 5-hmC and TET ...
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
... that 5‑methylcytosine (5mC) can be oxidized to 5‑hydroxymethylcytosine (5hmC) by the ten‑eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the ...
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A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels
... methylation. 5-hydroxymethylcytosine (5hmC) is the catalytic product of the Tet (Ten-11 translocation) family of enzymes and may serve as an intermediate of DNA ...both 5-methylcytosine (5mC) and ...
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Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability
... [7-9]. 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker that can be converted to 5-methylcytosine (5-mC) by the ten-eleven translocation (TET) gene family through a multistep ...
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Distinct and overlapping control of 5 methylcytosine and 5 hydroxymethylcytosine by the TET proteins in human cancer cells
... of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in an α-ketoglutarate- and Fe(II)-dependent manner ...generate 5-formylcytosine and 5-carboxylcyto- sine (5caC), both of ...
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Tissue type is a major modifier of the 5 hydroxymethylcytosine content of human genes
... of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of ...
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5-Hydroxymethylcytosine and Ten-Eleven Translocation Dioxygenases in Head and Neck Carcinoma
... converts 5-methylcytosine to 5-hydroxymethylcytosine ...and 5-hmC levels in head and neck squamous cell carcinoma (HNSCC) have not yet been ...analyzed 5-hmC levels and TET mRNA ...
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Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers
... modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and ...
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5-hydroxymethylcytosine and its potential roles in development and cancer
... the 5-carbon of cytosine, mostly within the CpG sequence context ...DNA. 5-hydroxymethylcytosine (5hmC) was initially found in the DNA of certain bacteriophages [3] and was reported in mammalian ...
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5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies
... marker 5-hydroxymethylcytosine, a functionally-significant indicator that has been shown to distinguish benign nevi from melanoma, was performed on all cases using immunohistochemistry and/or direct ...of ...
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Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer
... mark 5-hydroxymethylcytosine (5hmC) has recently been proposed as a novel candidate prognostic biomarker in several malignancies including ...of 5-methylcytosine (5mC) and can be further oxidized to ...
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Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma
... The methylation of cytosine in CpG islands is a modi- fication produced by DNMTs. Reversal of 5mC methyla- tion is accomplished in a multistep enzymatic process using Ten Eleven Translocation (TET) enzymes, thy- mine DNA ...
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Physiological and pathological implications of 5-hydroxymethylcytosine in diseases
... Recently, 5-hydroxymethylcytosine (5hmC), the product of 5-methylcytosine (5mC) demethylation, is emerging as a novel demethylation marker in many ...
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Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs
... To further elucidate the role of glucose in the dynamic regulation of 5mC and 5hmC, we performed an oral glu- cose tolerance test (OGTT) with a standard dose of 75 g glucose in 11 T2DM patients and 5 healthy ...
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Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI
... Zygote classification according to pronuclear morphology In this study, the dynamic patterns of 5mC and 5hmC were analyzed independently for the pPN and the mPN during pronuclear development in in vitro-produced equine ...
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5 hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer
... for 5-hmC enriched narrow and broad promoters in normal human colon. 5-hmC profiles for the top 5 loci of each promoter ...with 5-hmC ‘ narrow ’ promoters (top 1,000 ranked by 5-hmC ...
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