5-lipoxygenase-activating protein
Inhibition of 5 lipoxygenase activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
... that 5-lipoxygenase (5-LO) is a molecular determinant of these ...the 5-LO to macrophages of normal and chronically hypoxic rat lungs and also to vascular endothelial cells in chronically ...
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Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran
... Background: Stroke is a multifactorial disorder and a major cause of morbidity and mortality around the world. There are growing numbers of candidate gene pathways which are thought to be associated with stroke. Genes ...
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Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... precursor protein; BACE-1: β -site amyloid precursor protein cleaving enzyme 1; CNS: central nervous system; CREB: cAMP response element-binding protein; CTFs: C-terminal fragments; ELISA: ...
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Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study
... the 5-LO inhibitor zileuton to patients with severe asthma led to improvements in lung function ...the 5-LO pathway could confer beneficial effects on patients with persistent ...
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The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5 lipoxygenase activating protein
... of 5-LO, FLAP and GAPDH mRNA was performed in the GeneAmp 5700 Sequence Detection System (Applied Biosystems, Foster City, CA, USA) with the 2X Quantitect SYBR Green PCR Master Mix (Qiagen) used in accordance with ...
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A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye
... Respiratory syncytial virus (RSV) is an important cause of viral respiratory disease in children, and RSV bronchiolitis has been associated with the development of asthma in childhood. RSV spreads from the eye and nose ...
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Inhibition of the early asthmatic response to inhaled allergen by the 5-lipoxygenase activating protein inhibitor GSK2190915: a dose–response study
... The design was double-blind, three-way crossover, in three centers in the United Kingdom. Subjects were screened at least 14 days before the first treatment period. Eligible sub- jects received GSK2190915 10 mg and 50 mg ...
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Regulation of microsomal prostaglandin E2synthase 1 and 5 lipoxygenase activating protein/5 lipoxygenase by 4 hydroxynonenal in human osteoarthritic chondrocytes
... Twenty micrograms of total proteins from chondrocyte lysates treated with HNE under the indicated conditions were loaded for discontinuous 4 to 12% SDS-PAGE. Protein transfer, immunodetection and semiquantitative ...
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The HLA B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients
... arachidonate 5-lipoxygenase- activating protein), kinases (FYN, ATM), and inflam- mation (HMGB1, high-mobility group protein ...
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Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population
... (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5- lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk ...
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Augmentation of 5 lipoxygenase activity and expression during dengue serotype 2 infection
... Although dengue infection is characterized by an adult predominance and DENV serotype-2 is the most common circulating strain in Singapore, results from this study may not be applicable to younger patients with dengue ...
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Association between MEG3/miR-181b polymorphisms and risk of ischemic stroke
... Arachidonate 5-lipoxygenase-activating protein; ASW: African ancestry in Southwest USA; BDNF : Brain-derived neurotrophic factor; CEU: Utah residents with Northern and Western European ...
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Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1
... 5-LOX (1:300, (Chemicon International Inc. Temecula, CA, USA) and mouse monoclonal antibody against glycer- aldehyde 3-phosphate dehydrogenase (GAPDH) (1:5,000, Kangcheng Biotechnology Inc., Shanghai, China) at ...
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Lymphocytes stimulate expression of 5 lipoxygenase and its activating protein in monocytes in vitro via granulocyte macrophage colony stimulating factor and interleukin 3
... Monocytes were obtained from peripheral blood by previously described techniques (7a, 23). Briefly, blood was collected into acid- citrate-dextrose and red blood cells were allowed to sediment in the presence of dextran. ...
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<p>Lack of association between <em>ALOX5AP</em> genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses</p>
... Our study has some limitations that should be considered. First, the relationship between the ALOX5AP polymorphisms and the levels of leukotriene lipid mediators in IS patients was not evaluated due to lack of published ...
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Host control of Mycobacterium tuberculosis is regulated by 5 lipoxygenase–dependent lipoxin production
... with M. tuberculosis was associated with enhanced survival at high- dose aerosol challenge, although there were no apparent differenc- es in mortality at the lower inoculum infections. These contrasting outcomes of the 2 ...
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Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy
... bodies, A waves, and, later, delayed motor nerve conduc- tion velocities and decreased sensory nerve action po- tentials (Table 2). Moreover, a marked side difference in motor neuron conduction velocity and distal motor ...
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Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin triggered lipoxins in reperfusion
... and 5-LO expression, peritoneal leukocytes from mice with casein-induced peritonitis (2% casein for 4 hours) were collected as described (6), and total RNA was ...BLTR-III: 5′-TACGCCAGCGTCCTGCTT-3′; and ...
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Antioxidant and anticancer activities of polyphenolic compounds from three Acanthaceae medicinal species from Burkina Faso
... All the mediums and complements of cellular culture come from GIBCO-Invitrogen (Merelbecke, Belgium). The cells are cultivated in cellular culture bottles (T25 or T75) containing the culture medium MEM supplemented with ...
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Growth control of lung cancer by interruption of 5 lipoxygenase mediated growth factor signaling
... of 5-HPETE, 5-HETE d -lac- tone, and ...LTE4, 5-,12-, and 15-HETEs, and HPETEs, 15 HETE methyl ester, and 5-HETE d -lactone), and ...parent 5-eicosanoid derivative, as has been ...
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