A(2A) adenosine receptor
A<sub>2A</sub> adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE–knockout mice
... Abstract: Adenosine-induced coronary vasodilation is predominantly A 2A adenosine receptor (AR)-mediated, whereas A 1 AR is known to negatively modulate the coronary flow ...to ...
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A protective role for the A1 adenosine receptor in adenosine dependent pulmonary injury
... of adenosine are increased in the lungs of asthmatics (3), in which elevations correlate with the degree of inflammatory insult ...that adenosine may play a provocative role in asthma and COPD (5, ...6). ...
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Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy
... vaso-obliteration and hypoxia-induced revascularization (Zhang et al. 2015). This proposal is further substantiated by a recent large prospective phase III clinical study “Caf- feine Therapy for Apnea of Prematurity” ...
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Adenosine Receptors Machinery and Purinergic Receptors in Rat Primary Skeletal Muscle Cells
... for adenosine receptors (Castanon et ...which adenosine receptor (A 2A or A 2B ) leads to increases in cAMP levels, CGS21680, an A 2A adenosine receptor-selective agonist ...
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Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
... CD73-converted adenosine regulates platelet reactivity, we added the aforementioned inhibi- tors to MSC–platelet ...CD73-mediated adenosine generation causes platelet inhibition ...CD73-mediated ...
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Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine
... Interestingly, adenosine (released centrally and periph- erally as a breakdown product of ATP) is another neuro- modulator that seems to play a role in migraine pathophysiology ...(i) adenosine plasma ...
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Role of A2B adenosine receptor signaling in adenosine dependent pulmonary inflammation and injury
... lacking. Adenosine deaminase–deficient (ADA-deficient) mice develop pulmonary inflammation and injury that are dependent on increased lung adenosine ...
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Adenosine metabolism and murine strain–specific IL 4–induced inflammation, emphysema, and fibrosis
... on adenosine accumulation, ADA activity, and adenosine receptor expression in these ...in adenosine metabolism in C57BL/6 and Balb/c mice and dem- onstrate that these differences contribute to ...
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The role of HIFs in ischemia-reperfusion injury
... Abstract: The reduction or cessation of the blood supply to an organ results in tissue ischemia. Ischemia can cause significant tissue damage, and is observed as a result of a thrombosis, as part of a disease process, ...
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A systems pharmacology approach to the adenosine A1 receptor
... given receptor is often a function of the ...mammalian receptor- G protein ...to adenosine receptor signalling in yeast with a view to understanding the contribution of the ligand, ...
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The Adenosine Receptor Agonist 5’ N Ethylcarboxamide Adenosine Increases Glucose 6 Phosphatase Expression and Gluconeogenesis
... of adenosine A2 receptors increases cAMP levels, which are thought to mediate NECA-induced increases in serum glucose levels [7] because increases in cAMP production activate glycogen degradation ...
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Lehmann, Mandy (2008): The Effect of Lethal Toxin on the Respiratory Epithelium.. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Figure 2-7: Alternative splice variants of the TEM8 receptor. 10 Figure 2-8: The splice variants of the CMG2 receptor. 11 Figure 2-9: Anthrax toxin cycle. 12 Figure 2-10: Overview of the junction complex. ...
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The effect of receptor density on the binding and functional properties of the human adenosine A1 receptor
... II receptor family contain a group of 7TM receptors whose expression and pharmacological properties are dependent on interactions with accessory proteins termed receptor activity modifying proteins (RAMPs, ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... Objective: The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the trans- forming growth factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic ...
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Regulating STING in health and disease
... ADAR1: Adenosine deaminase acting on RNA 1; AGS: Aicardi-goutières syndrome; AMFR: Autocrine motility factor receptor; AMPK: Adenosine monophosphate activated protein kinase; ANA: Antinuclear ...
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“Platelet-associated regulatory system (PARS)” with particular reference to female reproduction
... There are experimental data demonstrating the pres- ence and actions of various neurotransmitters in the ovary, thus supporting the view that they might play a role in intraovarian regulatory mechanisms, although their ...
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Adenosine signaling promotes hematopoietic stem and progenitor cell emergence
... 60-6583 to EBs between days 4 and 6 significantly increased the number of hematopoietic colonies, including definitive erythroid (CFU-E), granulocyte/monocyte (CFU-GM), and multipotent ...
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Adenosine formed by 5′ nucleotidase mediates tubuloglomerular feedback
... underlying adenosine activ- ...Therefore, adenosine activ- ity achieved in these experiments met the conditions required to prove that TGF will not function normally unless adenosine activity is ...
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Effect of agonists of adenosine receptors on inflammatory markers in human Muller cells
... adenosine receptors. Recent studies have shown that inflammation plays a major role in the pathogenesis of diabetic retinopathy 29,30 . Several inflammatory markers have been reported which might be involved in ...
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Analgesic Effect of a Single Dose of Adenosine for Neuropathic Pain Reduction in a Patient with Primitive Neuroechtodermal Tumor
... Report of the Case: In this case report a 13-year-old male with primary neuroectodermal tumor (PNET) was administered in epidural space with adenosine to reduce his pain. The patient received 10ml of 0.25% ...
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