α Smooth muscle actin (αSMA)
Combined effects of interleukin-1α and transforming growth factor-β1 on modulation of human cardiac fibroblast function
... markers α-smooth muscle actin (αSMA) and connective tissue growth factor ...markers αSMA, CTGF, COL1A1 and ...in αSMA and blocked the gel contraction caused by ...
25
Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... genes α–smooth muscle actin (αSMA), CollagenIα1, and tissue inhibitor of metalloproteinases–1 (TIMP-1) in HSCs primed with the profibrogenic agent transforming growth factor–β (TGF-β) ...
18
Clonorchis sinensis lysophospholipase A upregulates IL 25 expression in macrophages as a potential pathway to liver fibrosis
... against α-smooth muscle actin (α-SMA) (Proteintech, Chicago, USA), IL-25 (R&D, Minneap- olis, USA), total ERK1/2, phospho-ERK1/2, total AKT, phospho-AKT, phospho-B-Raf (Cell ...
10
FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis
... of α-smooth muscle actin (α-SMA) in phLF led to inhibition of migration without affecting the FAK signaling pathway ...in actin dynamics may underlie the observed inhibition of ...
14
Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
... many α-smooth muscle actin (α-SMA)- positive cancer associated fibroblasts (CAFs) which in turn lead to an increased of an aberrant extracellular matrix (ECM) production [6, ...
12
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
... of α -smooth muscle actin ( α -SMA), fibroblast specific protein-1 (S100A4), COL-1, and FN were investigated by western blotting and quantitative real-time ...
11
Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study
... angiopoietin; α -SMA: α smooth muscle actin; BV/mm 2 : number of vessels per square millimetre; CCP: cyclic citrullinated peptide; CRP: C-reactive protein; DAS: disease activity score; ...
10
IL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts
... and α -smooth muscle actin ( α -SMA) was examined and the transforming growth factor (TGF)- β -related signaling pathways was evaluated in activated human lung fibroblasts (MRC-5 cells) ...
10
PAX7 is required for patterning the esophageal musculature
... anti-sarcomeric actin (5C5; 1:1000; Sigma-Aldrich), rabbit anti–α-smooth muscle actin (1:200; Abcam), rabbit anti-MyoD (1:500; Santa Cruz Biotechnology, ...
11
Immunohistochemical Evaluation of Stromal Myofibroblasts by Alpha Smooth Muscle Actin in Potentially Malignant and Malignant Lesions of the Oral Cavity: A Retrospective study
... of α-smooth muscle actin myofibroblasts in oral VC cases as compared to complete positivity in OSCC which they attributed to the lack of inductive effect of genetically altered carcinomatous ...
109
The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice
... and α-smooth muscle actin were increasing in the retina with the decreasing concentration of siRNA-PKCα, indicating that intraocular siRNA-PKCα can partly inhibit changes of markers for glia ...
10
Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
... monoclonal α-smooth muscle actin (α-SMA) antibody (A2547, Sigma-Aldrich), rabbit polyclonal fi- bronectin (FN) antibody (ab2413, Abcam, Cambridge, MA), rabbit polyclonal phospho-Akt ...
12
Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
... I, α-smooth muscle actin (α-SMA), fibronectin, and con- nective tissue growth factor (CTGF), compared with eutopic endometrial MSCs from women with or without endometriosis and that ...
13
Original Article All-trans retinoic acid in combination with collagen IV induces the differentiation of mouse embryonic stem cells into smooth muscle cells
... of smooth muscle cells (SMC) plays an important role in human diseases including atherosclerosis, hypertension and ...detect α-smooth muscle actin (α-SMA) and ...
7
Inhibition of airway remodeling in IL 5–deficient mice
... express α-smooth muscle actin and tenascin ...expressing α-smooth muscle actin ...influences smooth muscle layer thickness or levels of expression of ...
11
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
... contrast, α-smooth muscle actin (Acta2; also known as α-Sma) mRNA and that of other genes linked to airway remodeling, including collagen 1 and 3 (Col1a1 and Col3a1), fibronectin (Fn1), ...
17
Origin of neointimal endothelium and α actin–positive smooth muscle cells in transplant arteriosclerosis
... into α-actin–positive VSM ...of α -actin–positive smooth muscle cells on Dacron grafts, which apparently origi- nated from the bloodstream ...and smooth muscle stem ...
13
Smooth muscle α-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation
... targeting α-actin represents another, different tumor suppressive activity of ...of α-actin, reorganization of the cytoskeleton and resistance to the action of certain ...of ...
13
Myofibroblast expression in airways and alveoli is affected by smoking and COPD
... alpha-smooth muscle actin ( α -SMA) positive, spindle-shaped mesenchymal ...lar α-SMA filaments and extracellular Fn bundles, dilated rough endoplasmic reticulum (rER) and adherens-type ...
13
Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury
... vascular smooth muscle cells (VSMCs) contributes to the development and progression of vascular lesions, little is known regarding the molecular mechanisms of phenotypic modulation in ...for smooth ...
10