ABC drug transporter substrate and expression
Effect of Metabolic Disease and Xenobiotic Exposure on Hepatic ATP-Binding Cassette (ABC) Drug Transporter Expression
... based drug therapies for MetS such as amylin and GLP-1 agonists are gaining importance (Schmitz et ...hepatic Abc transporter ...hepatic drug transporter regulation by metabolic ...
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Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression
... Materials and methods Brain samples The Erasmus MC Research Ethics Board waived the need for formal ethics approval according to the Dutch Law on Medical Research in Humans. Brain cortex and brain ven- tricle/choroid ...
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Abscisic acid is a substrate of the ABC transporter encoded by the durable wheat disease resistance gene Lr34
... Jochen ; Sucher, Justine ; Martinoia, Enrico ; Keller, Beat Abstract: The wheat Lr34res allele, coding for an ATP-binding cassette transporter, confers durable resistance against multiple fungal pathogens. The ...
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Localization, Regulation, and Substrate Transport Properties of Bpt1p, a Saccharomyces cerevisiae MRP-Type ABC Transporter
... the expression patterns of YCF1 and BPT1 differ ...YCF1 expression is markedly increased by cadmium, adenine limitation in an ade2 strain, or overexpression of the stress-responsive transcription factor ...
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In vitro methods to test drug ABC transporter interaction optimization and validation studies
... ABCB11 transporter plays a key role in canalicular bile salt transport and in regulating the bile salt concentration in the hepatocytes as well as in the systemic ...of drug development. Membrane based ...
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Intracellular Localization of ABC Transporter TAPL Differs between Transient and Stable Expression
... Abstract Transporter associated with antigen processing (TAP)-like (TAPL; ABCB9) is a half-type ABC transporter with sequence similarity to TAP1 and TAP2 that function in the ER ...stable ...
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Predicting Transporter Proteins and Their Substrate Specificity
... prokaryotic and eukaryotic genomes, highlighting the importance of transporters in all living species [RP05]. While many membrane proteins sequences are known due to the large number of recent genome projects, their ...
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An ABC pleiotropic drug resistance transporter of Fusarium graminearum with a role in crown and root diseases of wheat
... Other ABC transporters have roles in virulence and PDR but specific substrates related to their hosts are yet to be ...graminicola ABC transporters are involved in virulence towards wheat (Stergiopoulos et ...
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Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD)
... the expression of GFP-fusion proteins such as GFP-LARD0, GFP-LARD1, and GFP-TliA (GFP fused to entire ...an ABC transporter, were UV-irradiated to identify the expression of GFP-fusion ...
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Biophysical Characterization of an ABC L methionine Transporter
... other ABC transporter studies, the overall data support a transport mechanism where the binding protein first binds to its substrate in the periplasm to increase the local substrate ...
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Updated inventory, evolutionary and expression analyses of G (PDR) type ABC transporter genes of rice.
... plant ABC transporters transport molecules that are important not only for plant growth and development but also for survival under adverse conditions, use of these genes in molecular breeding through transgenic ...
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Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues
... mRNA expression levels of target and reference ...mRNA expression levels were corrected by PCR efficiency and the reference genes normalization fac- tor, by normalizing target mRNA Ct values to those of ...
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Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics
... These observations indicate that ABCG2/BCRP recognizes erlotinib as a substrate in vivo. Sunitinib, an oral multitargeted TKI for vascular endothe- lial growth factor receptors 1, 2, and 3, platelet-derived growth ...
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Human ATP-binding cassette (ABC) transporter family
... specific substrate — either with or against its concentration gradient — and the conformational change in the transporter protein is important in this transfer ...
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Functional Characterization of Candida albicans ABC Transporter Cdr1p
... Cdr1p-GFP expression at the cell periphery also confirmed that the GFP tagging of Cdr1p did not interfere with its localization (data not ...analyzing drug susceptibilities of cells harboring CDR1 or the ...
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ABC transporter research: going strong 40 years on
... human ABC transporter to produce diffracting crystals in a structural genomics project but its precise function remains frustratingly obscure ...probe ABC transporter structure and mechanism ...
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Protein kinase C-dependent regulation of human hepatic drug transporter expression
... of transporter expression alteration in HepaRG cells, we investigated whether exposure to other PMA-unrelated inducers of EMT can also result in changes in transporter expression similar to ...
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The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model
... acid ABC transporter substrate-binding protein homologous to AapJ protein was found to be involved in Brucella abortus ...Besides, expression of diverse genes was up-regulated in the Δ27735 ...
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The gene expression analysis of Arabidopsis thaliana ABC transporters by real-time PCR for screening monolignol-transporter candidates
... precursors. ABC transporter genes subjected to expression analysis were chosen based on two criteria for screening candidate transporter genes related to ...The expression levels of 15 ...
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Immunolocalization and Cellular Expression af Key Abc Transporter Proteins and Their Correlation with the Grades and Subtypes of Canine Mammary Tumour
... multiple drug resistance as already faced by medical ...of drug resistance [10]. The most studied ABC transporter proteins include breast cancer resistance ...
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