ABCG5/ABCG8
Biliary cholesterol secretion by the twinned sterol half transporters ABCG5 and ABCG8
... in ABCG5/ABCG8 trans- genic ...the ABCG5 and ABCG8 genes ...in ABCG5 and ...includes Abcg5 and Abcg8 as a region that is associated with cholesterol gallstone susceptibil- ...
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Coexpression of ATP binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface
... either ABCG5 or ABCG8 cause an identical phenotype (1, 15) is also con- sistent with ABCG5 and ABCG8 forming a ...that ABCG5 and ABCG8 coim- munoprecipitate indicates that the ...
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Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat
... Flaxseed is used as a herbal medicine which has high amount of lignans, phytoestrogen, soluble fiber and alpha-linolenic acid. Many studies have shown that these composites have hypolipidemic and antioxidant properties. ...
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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
... mouse Abcg5 and Abcg8 in response to dietary cholesterol ...between ABCG5/ABCG8 activity and sterol transport rates has not been ...of ABCG5 and ABCG8 is sufficient to promote ...
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Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine
... transporters, ABCG5 and ABCG8, encoded by a single locus, STSL, are known to cause this disease ...the Abcg5/Abcg8 double knockout mice, Graf et al has shown that by inoc- ulating them with ...
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Heterozygous familial hypercholesterolaemia in a pair of identical twins: a case report and updated review
... Both ABCG5 and ABCG8 were demonstrated to inhibit the absorption of cholesterol and plant sterols from the diet by mediating the efflux of these sterols from enterocytes back into gut lumen, and by ...
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Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease
... transporters ABCG8, ABCG5 and NPC1L1 were analysed (Figure ...exporter ABCG8 and ABCG5, no significant changes in expression were apparent when stratified according to gallstones (Figure 1A ...
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A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
... proposed Abcg5/sterolin-1 and Abcg8/sterolin-2 to function as obligate ...out Abcg8/sterolin-2 alone is equivalent to a functional loss of both ...that Abcg8/sterolin-2 expression is required ...
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Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease
... vitro. ABCG5/G8 are key players in regulating biliary cholesterol content [21, ...of ABCG5 and ABCG8 mRNA in gallstone patients has been reported [30], which represents the main defect leading to ...
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Congenital macrothrombocytopenia is a heterogeneous disorder in India
... cases), ABCG5 (12 cases), MYH9 (11cases), GP1BA (4 cases) and GP1BB (3 cases) were identified in 48 of the 112 index cases (Table ...in ABCG5 (Table ...or ABCG8 in DNA from the first 50 index cases ...
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Effect of Eight Weeks Aerobic Exercise and Green Tea on Atherogenic Ratio and ABCG8 Gene Expression of PBMC Globules in Overweight Women
... 4, ABCG8, tissue ghrelin and nesfatin and demonstrated that physical acitvitt leads to an increase in the gene expression of ABCG4, ABCG8 and tissue nesfatin in the exercised groups compared to the control ...
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The Effect of Eight Weeks Aerobic Exercise on the Atherogenic Ratio and ABCG8 Gene Expression in PBMC Globules of Overweight Women
... increases ABCG8 gene expression in PBMC cells in middle-aged men after CABG ...4, ABCG8, tissue ghrelin and nesfatin ...ABCG4, ABCG8 and tissue nesfatin gene ...in ABCG5 and ABCG8 gene ...
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β-Cryptoxanthin modulates the response to phytosterols in post-menopausal women carrying NPC1L1 L272L and ABCG8 A632 V polymorphisms: an exploratory study
... Traditionally, it has been considered that carotenoids absorption was a simple diffusion process. However, recent studies have demonstrated the presence of proteins involved in the transport of carotenoids into ...
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Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
... ABCG5 and ABCG8 are target genes of LXRs [7, 36]. LXRα is directly regulated by PPARγ [34], and thus this might explain how LXRα cooperates with PPARγ to ex- pedite cholesterol efflux in the intestine and ...
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Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats
... Background: The theory of Chinese medicine believes rage harms normal liver function, namely ’ raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid ...
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Liver X Receptor: A novel therapeutic target
... transport from macrophages is shown in (Þ g. 2). The uptake of modiÞ ed lipoproteins by macrophages results in increased LXR transcriptional activity and efß ux of cholesterol to lipid-poor apoA-I by ABCA1 and to HDL by ...
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Advances in Research on the Pathogenesis of Type 2 Diabetes Complicated with Gallstone
... that ABCG5 and ABCG8 mRNA expression is significantly in- creased in cholesterol stones and cholesterol polyps ...[28]. ABCG5/G8 is mainly expressed in the liver, gallbladder and small ...that ...
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Absorption intestinale des vitamines liposolubles
... transporteurs ABCG5 et G8 (Iqbal et Hussain, 2009), initialement impliqu es dans le transport inverses du cholest erol et des phytost erols, partici- pent a ce ph enom ene dans le cas des vitamines ...
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Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet
... Abcg8 — physiologically important biliary cholesterol ex- porters [ 15 ], there were little differences in their mRNA levels between the liver of WT and L1-Tg mice fed a HFD (Additional [r] ...
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The intestinal microbiota regulates host cholesterol homeostasis
... Relative expression of genes related bile acid synthesis (Cyp8b1) and bile secretion (Abcg5, 8 and 11) in the liver of mice colonized with the microbiota from normocholesterolemic donors[r] ...
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