ABT/IT
Cooperation of IRAK1/4 inhibitor and ABT-737 in nanoparticles for synergistic therapy of T cell acute lymphoblastic leukemia
... 7.5 in contour plots for Y, variable B and C have a small variable range at a fixed level of variable A (Figure 1D–F). It was also confirmed that variable A is the main factor. Then, we calculated the coded variables for ...
10
Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC
... by ABT-737 promotes Bax and Bak oligomerization and programmed cell death of malignant cells ...[9]. ABT-737 was shown to potently act as a single-agent drug on a number of cell lines [10–12] but also ...
14
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
... single-agent ABT-199 was studied in a phase 2, open-label, multicenter trial in patients (pts) with high- risk R/R AML and in untreated patients who were unfit for intensive chemotherapy ...mg ABT-199 on ...
8
Wearable accelerometry-based technology capable of assessing functional activities in neurological populations in community settings: a systematic review
... utilize ABT- methods capable of remotely assessing functional activities in neurological populations, it assists researchers in mak- ing informed, time-sensitive decisions regarding which current methods to use in ...
13
Developing novel therapeutic strategies for targeting the p53 pathway in renal cell carcinoma
... and ABT-737 synergise to inhibit the proliferation of RCC cells and the degree of synergy observed was greater in the cell lines harbouring wild type p53 when compared to those harbouring mutant ...and ...
254
Effects of senolytic drugs on human mesenchymal stromal cells
... In this study, ABT-263 revealed moderate selectivity for senescent MSCs but also affected non-senescent cells, as described previously [17]. For quercetin, da- nazol, and nicotinamide riboside we did not observe ...
6
Acquired resistance to venetoclax (ABT-199) in t14;18 ) positive lymphoma cells
... the apoptotic function of BIM was detected. Second, together with JNK1/2 phosphorylation, events pointing to autophagy activation such as BIM/BECLIN1 and BCL2/ BECLIN1 dissociation and SQSTM1/p62 degradation were ...
11
Effect of abatacept on the immunogenicity of 23 valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients
... Polysaccharides are able to elicit immune responses in the absence of T-cell help, although the magnitude of the response can be marginally affected by immunosup- pressive treatments [7]. Recent studies with pneumococcal ...
10
Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells
... and WEHI-539. It is also noteable that in this cell line ABT-737 and WEHI-539 induced apoptosis when they were tested as single agents. Thus, the lack of synergy between carboplatin and these compounds in Ovcar-4 ...
9
ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer
... of ABT- 263 action, we employed RPPA to evaluate 175 proteins expression on JHESO EC cells treated by ...importantly, ABT-263 alone or in combination of 5-FU demonstrated strong inhibitory effect on ...
14
Combining virtual model and cone beam computed tomography to assess periodontal changes after anterior tooth movement
... tissue. Although many studies investigating the ana- tomical shape of the gingiva, the depth of periodontal pockets, and the length of the junctional epithelium have been published [17, 21], relatively few studies ...
8
Annis_unc_0153D_16567.pdf
... of ABT-737 to HeLa cells resulted in increased Bim levels, and that this increase in Bim occurred in a JNK-dependent ...of ABT-737 as a cancer therapeutic, it negatively impacts our ability to use this ...
179
Outcome in hip fracture patients related to anemia at admission and allogeneic blood transfusion: an analysis of 1262 surgically treated patients
... Anemic patients were more likely to be older and to be men, to have a trochanteric fracture and a higher ASA score and to receive an ABT; the latter two results were demonstrated by others as well [7,8]. These ...
7
Methodology of assessment and reporting of safety in anti malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review
... Methods A systematic literature review following the methodology described in the PRISMA statement [24] was conducted to identify studies measuring the efficacy of ABT and QBT in pregnan[r] ...
10
Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT 199 and ABT 737
... first ABT-737 and then ABT-199 as research tools and as ...by ABT-737 ...[42]. ABT-737 causes prolonged thrombocytopenia associated with BCLX L targeting, but ABT-199, which is more ...
20
Bcl-2 high mantle cell lymphoma cells are sensitized to acadesine with ABT-199
... proteins. ABT-199 is the most selective BH3 mimetic against Bcl-2, which specifically binds to Bcl-2 but not to Mcl-1 and Bcl-X L ...MCL, ABT-199 induces apoptosis [53] and its activity was found to ...
14
How Are the Mighty Fallen...In The Most Obscure Places!
... The purpose of this article is to analyse the inquiry conducted by the Australian Broadcasting Tribunal (ABT) into the fitness and propriety of Alan Bond and Bond Media Ltd to hold com[r] ...
16
Wiley Drilling for Gold How Corporations Can Successfull pdf
... MYOB Mind Your Own Business, 117 NAICS codes North American Industry Classification System, 21–22 NASDAQ National Association of Securities Dealers Automated Quotation System, 55 National[r] ...
241
Wiley Enterprise Resource Planning pdf
... See General manager Manufacturing execution systems MESs, 46 Manufacturing Resource Planning MRP II: defined by APICS, 10 in evolution of ERP, 8–10 and importance of JIT, 14 overview of, [r] ...
385