Acetylcholine receptors
A novel angiogenic pathway mediated by non neuronal nicotinic acetylcholine receptors
... We have recently reported that nicotine has angiogenic effects, which appear to be mediated through non-neuronal nicotinic acetylcholine receptors (nAChRs). Here, we describe the endogenous cholin- ergic ...
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Lophotoxin insensitive nematode nicotinic acetylcholine receptors
... Caenorhabditis elegans is an organism well-suited to the study of fundamental questions in neurobiology, as its nervous system consists of only 302 cells (381 cells in males) and has been mapped in its entirety (White et ...
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Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids
... Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels mediating fast synaptic transmission throughout the peripheral and central nervous ...these receptors present alluring ...
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Imidacloprid actions on insect neuronal acetylcholine receptors
... housefly (Musca domestica) head membranes. While these studies suggested that certain nitromethylenes may act on both nAChRs and mAChRs, evidence is accumulating that their primary site of action is at nicotinic ...
8
Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis
... nicotinic acetylcholine receptor in muscles were shown to disturb neuromuscular signal transduction and mark the cells for complement mediated lysis ...muscarinic acetylcholine receptors (hmAchR) of ...
7
The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo
... nicotinic acetylcholine receptors (AChRs) recycle back into the postsynaptic membrane after internalization to intermingle with not-yet-internalized ‘pre-existing’ ...recycled receptors in functional ...
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Nematode nicotinic acetylcholine receptors: a single channel study in Ascaris suum and Caenorhabditis elegans
... nACh receptors on the muscle bag membranes of Ascaris ...for receptors in the different species (Eyre, ...nicotinic acetylcholine receptors (Robertson et ...
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Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
... Abstract: We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm) block ion pores by binding to ...
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Possibility of “Comet Like” Transport of Acetylcholine Receptors in Command Helix Neurons in Cellular Analog of Habituation
... of acetylcholine receptors by actin microfilaments without the participation of myosin motors in the depression of acetylcholine-induced inward chloric current (ACh-current) in command neurons of ...
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Molecular mechanisms of allosteric modulation of nicotinic acetylcholine receptors
... Nicotinic acetylcholine receptors (nAChR) are part of the Cys-loop family of ligand-gated ion channels, and are implicated in a wide variety of neurological disorders such as nicotine addiction, ...
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Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids
... Position 276 is conserved as a charged residue, either positive or negative, in the majority of ACh receptor subunits, but not in other members of the superfamily. Position 429 is often, but not always charged, being ...
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Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila
... It may be that the RNAi knockdown is 353 less efficient at affecting the physiology of 354 because the knockdown is less efficient at reducing protein levels, or because 355 KCs express [r] ...
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Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors
... on acetylcholine binding protein (AChBP) orthologs from mollusks has led to important new insights into the structures of Cys-loop receptor ligand-binding domains 5–8 ...
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The pharmacology of gamma aminobutyric acid and acetylcholine receptors at the echinoderm neuromuscular junction
... An early suggestion that an inhibitory neurotransmitter substance existed in echinoderms came from the work of Ernst Florey (for a fascinating history of Factor I/GABA, see Florey, 1991). His extract, ‘Factor I’, ...
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Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity
... group of Prof. S. Tzartos) and in Shemyakin- ovchinnikov Institute of Bioorganic Chemist ry, Moscow, Russian Federation (Prof. V. Tsetlin). Since the peptides were quite different in amino acid composition, the resulting ...
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Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors
... tinic receptors (α7 nAChR) ...choline, acetylcholine or synthetic α7 nAChR agonist PNU 282987 into the incuba- tion medium inhibited Ca 2+ accumulation in ...
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Neuronal control of localized inflammation through expressed nicotinic acetylcholine receptors: a study carried out in mice
... process acetylcholine can interact with a7nAChRs expressed by macrophages and other cytokine- producing cells, down-regulate proinflammatory cytokine synthesis, and prevent tissue damage ...
5
Downregulation of α7 nicotinic acetylcholine receptors in peripheral blood monocytes is associated with enhanced inflammation in preeclampsia
... The cholinergic anti-inflammatory pathway regulates systemic inflammatory responses and plays an important role in a variety of inflammation-related disorders, such as hypertension and kidney diseases [10–12]. In the ...
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Effects of TI-299423 on Neuronal Nicotinic Acetylcholine Receptors
... Thankfully, unlike the α6-containing receptors, α4β2*-nAChRs express readily in oocytes and mammalian cell lines. This makes the effects of nicotine, ACh, and other nicotinic compounds on these receptors ...
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Fluorescence Microscopy of Nicotinic Acetylcholine Receptors
... α5α4β2 receptors are trafficked differently than α4β2 receptors, we first expressed these receptors heterologously in clonal cell lines N2a and ...α7* receptors, whose expression is ...
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