acid-sensing ion channels
Acid sensing ion channels: potential therapeutic targets for neurologic diseases
... of acid-sensing ion channels (ASICs), which according to cumulative evidence, significantly contributes to inflammation, mitochondrial dysfunction, and other pathologic mechanisms ...
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Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat
... Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central ...
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Diarylamidines: high potency inhibitors of acid- sensing ion channels
... Acid-sensing ion channels (ASICs) are proton-gated cation channels that are predominantly expressed in the nervous ...these channels and provide probes for their physiological ...
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Acid Sensing Ion Channels (ASICs) in NS20Y cells – potential role in neuronal differentiation
... of ion channels, particularly those of Ca 2+ -permeable channels, have been suggested to play a ...of acid-sensing ion channels (ASICs) in NS20Y cells, a neuronal cell ...
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Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
... gated ion channels, acid-sensing ion channels (ASICs) ...These channels are associated with various physiological and pathophys- iological functions including regulation ...
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Acid-sensing ion channels: trafficking and synaptic function
... Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels which are expressed pri- marily in the nervous system ...that ion selectivity of ASICs can be ...
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The role of acid sensing ion channels in epithelial Na+ uptake in adult zebrafish (Danio rerio)
... The first series of fluxes investigated concentration-dependent effects of 4′,6-diamidino-2-phenylindole (DAPI) at 0, 0.01, 0.1, 1, 10 and 100 µmol l −1 on Na + uptake. Since DAPI had not been used in adult zebrafish ...
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Amiloride blockable acid sensing ion channels are leading acid sensors expressed in human nociceptors
... as acid sensors in vivo within a pathophysiologically relevant pH range (pH ≥ ...ASIC-3 channels (20, ...ASIC channels show an order of magnitude with a higher affinity for protons than the ...
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Structure, function, and pharmacology of acid- sensing ion channels (ASICs): focus on ASIC1a
... A large ECD is not specific to ASICs, but shared by all DEG/ENaC channels, although its size can vary. Homology between different ASICs is larg- est in the second two-thirds of the ECD, whereas some parts of the ...
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Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
... tional channels with other ASIC subtypes and thus modulate their pH sensitivity and channel ...ASIC channels located at the interface between two subunits, whereas cations may access the channel from the ...
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A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell cultures
... activate acid-sensing ion channels (ASICs) both on pre- and postsynaptic ...selective acid-sensing ion ...of acid-sensing ion channels could ...
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Original Article Roles of acid-sensing ion channel 3 and calcitonin gene-related peptide in the hypersensitivity of dorsal root ganglia neurons in a rat model of visceral pain
... of acid-sensing ion channel 3 (ASIC3) and calcitonin gene-related peptide (CGRP) in the hypersensitivity of dorsal root ganglia neurons (DRG) in a rat model of visceral ...ASIC3 ion ...
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Ion Channels Proteins with a Hole
... Predict Function, from Structure, given Fundamental Physical Laws... Current in One Channel Molecule is a Random Telegraph Signal..[r] ...
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Ion channels in human axons
... K^ channels, it appears that the “ball” can only bind to the open channel, and must unbind before the channel can close, giving N-type inactivation in this channel several of the characteristics of open-channel ...
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CROWDED CHARGES IN ION CHANNELS
... of channels and proteins that I will describe the underlying situation at some ...an ion through a channel 1.5 nm long is 100 ns [295]—one ion crossing a channel every 160 ns produces 1 pA of ...
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Ionizable side chains at catalytic active sites of enzymes
... 2011a). Ion specific properties of bulk electrolytes have been treated in this tradition with some success for a long time (Friedman 1981; Torrie and Valleau 1982; Patwardhan and Kumar 1993; Durand-Vidal et ...of ...
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Poisson Fermi Approach to Ion Channels
... of Crowded Spheres & Saturation of Concentration Largest effect of finite size is saturation Saturation cannot be described at all by classical Poisson Boltzmann approach and is describe[r] ...
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A physical mechanism for large-ion selectivity of ion channels
... So far we have only described the addition of a penalty for the solvent to enter the filter. We now consider how such a penalty may arise in ion channels. One kind of penalty is geometric; the solvent’s size ...
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Chemical-Scale Studies of G Protein-Coupled Receptors and Ligand-Gated Ion Channels
... entering/exiting the agonist binding site – and “gating” events – the equilibria between open and closed states of the channel. Without detailed kinetic analyses, typically at the single channel level, it is not possible ...
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Single Ion Channels
... Ion channels are studied one molecule at a time as they perform their natural function thanks to two technologies, the patch clamp (Sakmann & Neher, 1995) of channels in cells and reconstitution ...
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