action potential duration
Cycle length dependence of human action potential duration in vivo Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady state frequencies
... monophasic action potentials from the human heart, we studied in 17 patients the effects on ventricular action potential duration (APD) of three clinically pertinent cycle length ...
9
The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study
... the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac mechanical and ...
16
Heterogeneity of the action potential duration is required for sustained atrial fibrillation
... of action potential duration of the atria similar to observations in patients with ...upon action potential duration ...the action potential ...the action ...
13
Contraction force versus action potential duration of cardiomyocytes: which methodology is more informative for selection of effective 1,4-dihydropyridine compounds in experimental research?
... AP duration, more signally at 90% repolariza- tion ...AP duration, more pronounced at early depolari- zation (APD 10 and APD 25 ...AP duration in the OSI-9719 group at the doses of 10 –4 mol/L ...
10
Dispersion of cardiac action potential duration and the initiation of re-entry: A computational study
... Action potentials were initiated in each virtual tissue by holding the membrane voltage along one edge at 0 mV for 2 ms. We measured APD to 90% recovery (APD 90 ) at every grid point. We estimated APD dispersion ...
16
Dispersion of cardiac action potential duration and the initiation of re-entry: A computational study
... The behaviour of re-entry in 3 D tissue is more complex than in 2 D, especially when the effects of rotational anisotropy and transmural differences in action potential shape and duration are taken ...
15
Ionic Mechanisms of Desflurane on Prolongation of Action Potential Duration in Rat Ventricular Myocytes
... in the presence of desflurane could be associated with time- dependent closure of the open channels, the magnitude of current inhibition at various times after the initiation of the depolarizing pulse was determined at a ...
9
Insights into the arrhythmogenic substrate of the human heart: An evaluation of dynamic influences on QT dispersion
... on action potential duration or ...of action potential duration (JT dispersion) whilst dispersion of inter ventricular conduction time (QRS dispersion) remained relatively ...on ...
236
Mechanoelectrical feedback: independent role of preload and contractility in modulation of canine ventricular excitability
... and action potential duration, we determined the stimulus strength-interval relationship and recorded monophasic action potentials in isolated canine left ventricles contracting ...
9
Ouabain effects on intracellular potassium activity and contractile force in cat papillary muscle
... electrophysiological measurements were quiescent except for isolated stimulation to confirm impalement and record action potential duration. Muscles used for contractile force measurements were ...
16
The pharmacology of three inwardly rectifying potassium Channels in neonatal rat cardiac myocytes.
... Action potential duration and activation of the ATP-sensitive K+ current in isolated guinea pig ventricular myocytes. Strong Voltage-Dependent Inward Rectification[r] ...
220
Vitamin E administration attenuates the tri iodothyronine induced modification of heart electrical activity in the rat
... the action potential duration is shortened in hyperthyroidism and lengthened in ...hormone action on heart electrophysiology has not been studied ...
6
Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers
... both action potential duration (APD) and effective refractory period (ERP) and made the ERP long relative to APD; the latter alteration was more prominent in ...
16
Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats
... dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were ...
11
Role of intracellular calcium handling in force interval relationships of human ventricular myocardium
... Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability to alterations in the strength of contraction produced by changes in stimulation ...
16
Original Article Hydrogen sulfide improves cardiomyocytes electrical remodeling post ischemia/reperfusion injury in rats
... The potential impact of H 2 S on cardiomyocytes electrical remodeling post ischemic insult is not fully explored ...the action potential duration (APD), inhibited L-type Ca 2+ channels and ...
8
Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... controversial because of the discrepancy between the low levels of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ischemia. We studied the effects of ...
7
The roles of mid-myocardial and epicardial cells in T-wave alternans development: a simulation study
... the action potential duration and amplitude during the first part of the repolarization ...of action potential properties would differentially influence T-wave alternans measurements at ...
21
Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence
... and action potential duration (APD) were observed in rat experiments but not in ...and action potential (AP) morphology contributed significantly to determining influence of ...
15
Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.
... for action-potential duration (ADP 90 ) under baseline conditions, in the presence of isoproterenol (ISO), or in the presence of ISO plus HMR1556 at cycle lengths (CLs) of 500, 1000, and 2000 ...
32