activated B cell
Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447
... in cell lines derived from a variety of additional lymphoid ...poor-prognosis activated B-cell-derived subtype of diffuse large B-cell lymphoma ...
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Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
... In activated B cell DLBCLs (ABC-DLBCLs), a class of DLBCLs that respond poorly to current therapies, chromosomal translocations and amplification lead to constitutive expression of the B ...
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Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma
... Background: Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor ...κ B, played an important role in the ...
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Up-regulation of Lamin A/C Expression in Epstein-Barr Virus Immortalized B Cells and Burkitt Lymphoma Cell Lines of Activated B Cell Phenotype
... A, B and C, the nuclear intermediate-filament proteins, play a role in epigenetic ...Lamin B is expressed in all nucleated cells studied, Lamin A/C are transcribed in most somatic cell types except ...
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Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma
... of B-cell lymphomas, especially for those with activation of NF- κ ...by B-cell specific CD40 signaling responsible for NF- κ B continuous activation with a spleen monoclonal ...
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Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation
... Fbw7 inhibits apoptosis regulators downstream of Stat3 Constitutively active Stat3 signaling leads to the upregula- tion of many downstream target genes in ABC-DLBCL, and our data indicate that Fbw7 could inhibit the ...
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Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia
... and B-cell receptor-mediated functions ...including activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) ...
6
Lenalidomide in heavily pretreated refractory diffuse large B cell lymphoma: a case report
... presumptive cell of origin, there are two primary DLBCL subtypes with dis- tinct pathophysiology: germinal center B-cell (GCB) and activated B-cell (ABC)/non-GCB ...
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Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma
... Intraocular lymphoma is diagnosed histologically with immunohistochemistry, flow cytometry, and PCR ana- lysis [2]. Typically, intraocular lymphoma is of the non- germinal center B cell, or activated ...
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STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
... CDKN2A/ B (Additional file 1: Table S1). CD79B is a subunit of the B-cell-receptor (BCR) and has been implicated as an oncogenic driver, primarily in activated B-cell (ABC) ...
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Spontaneous remission in diffuse large cell lymphoma: a case report
... and activated B-cell (ABC) phenotype associated with Epstein–Barr virus (EBV) are potentially linked with a subgroup of patients with propensity for ...
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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
... ABC-DLBCL: Activated B cell-like diffuse large B cell lymphoma; BAFF/ TNFSF13B: B cell-activating factor; BAFFR: B cell-activating factor receptor; BCAP: ...
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Clinicopathologic implication of microRNA 197 in diffuse large B cell lymphoma
... large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma, accounting for 30–40% of non-Hodgkin lymphoma cases ...two cell-of-origin (COO) sub- types, i.e., germinal center B ...
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MYC chromosomal aberration in differential diagnosis between Burkitt and other aggressive lymphomas
... aggressive B-cell lymphomas, and identified a consistent gene panel characteristic of molecular ...distinguished activated B-cell-like (ABC) or germinal-center B-cell-like ...
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Establishing Phenotypic Features Associated with Morbidity in Human T-Cell Lymphotropic Virus Type 1 Infection
... of activated virus-specific CD8 ⫹ T lymphocytes in the periph- eral blood and spontaneous proliferation of mononuclear cells in vitro have also been reported (17, 18, ...of B cells, leading to lower T ...
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The characterisation of a T cell response to human rhinovirus
... autologous B cells could be immortalised by transforming with Epstein-Barr virus or alternatively, PBMC could be obtained from the same individual and frozen until further ...
226
Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy: an aggressive and primary refractory disease responding to an immunomodulatory agent
... rituximab, cyclophosphamide, vincristine, doxorubicin and prednisone (R-CHOP) [6]. Another clinical parame- ter reflecting the heterogeneity of this disease is the pres- ence of monoclonal gammopathy (MG) in some ...
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Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma
... In 2016, Swerdlow et al. [13] published a proposal of revision in the WHO classification of 2008. This group of authors recognized DHL and THL as clin- ical and pathological categories, designated high- grade ...
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The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
... resting B cells and inhibits B cell proliferation ...of B cells in the spleen ...CD40-activated B cells is poorly ...T cell-mediated immune response in ...on B ...
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Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection
... B binding sites, a calcium- and cyclic-AMP-responsive element (CRE), and an AP-1 and Sp1 cis-binding site ...the cell type and stimulus (10, 22, 27, 29, ... B, cyclic AMP, and ...in ...
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