Activated B-Cell-Like
Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma
... Background: Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor ...κ B, played an important role in ...
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Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation
... center B-cell-like subtype of DLBCL showed reduced Fbw7 expression compared with the germinal center B-cell (GBC) subtype, and low Fbw7 expression was associated with a worse ...
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MYC chromosomal aberration in differential diagnosis between Burkitt and other aggressive lymphomas
... aggressive B-cell lymphomas, and identified a consistent gene panel characteristic of molecular ...distinguished activated B-cell-like (ABC) or germinal-center ...
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Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia
... and B-cell receptor-mediated functions ...including activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) ...
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The role of B cell antigen receptors in mantle cell lymphoma
... a B cell is the expression of a BCR and, upon its terminal differ- entiation into a plasma cell, the secretion of highly spe- cific ...All B cells keep expressing their clone-specific ...
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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
... ABC-DLBCL: Activated B cell-like diffuse large B cell lymphoma; BAFF/ TNFSF13B: B cell-activating factor; BAFFR: B cell-activating factor receptor; ...
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Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatment
... large B cell lymphoma (DLBCL), the most com- mon subtype of non-Hodgkin lymphoma (NHL) with ag- gressive property could be divided into three subgroups based on gene expression profile: germinal centre ...
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The Epstein-Barr Virus Promoter Initiating B-Cell Transformation Is Activated by RFX Proteins and the B-Cell-Specific Activator Protein BSAP/Pax5
... a cell-type-specific manner ...cells. Like Wp, the activity of HBV enh-I is dependent on the binding of RFX and CREB proteins at similar locations upstream of the transcription start site ...in B ...
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A regulatory effect of IL 21 on T follicular helper like cell and B cell in rheumatoid arthritis
... of activated CD4 + and CD8 + T cells [5] and limit the differentiation of inducible regulatory T cells ...Tfh cell differentiation via the upregulation of Bcl-6, the transcription factor of Tfh cells ...Tfh ...
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Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma
... Aberrant expression of the programmed death-ligand 1 (PD-L1, also known as B7-H1 or CD274) checkpoint molecule has been reported in many cancers such as breast, lung and colon tumors as well as during chronic viral ...
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Müller glia: stem cells for generation and regeneration of retinal neurons in teleost fish
... achaete-scute like 1a; Alcama, activated leukocyte cell adhesion molecule a; Apobec2a/2b, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a/2b; ApoE, apolipoprotein E; ...
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Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447
... Finally, we undertake the first meta-analysis and functional evaluation of PIM1 mutations found in DLBCL. Fifteen years ago, the gene was found among several prominent proto-oncogenes that are recurrently mutated by ...
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Activation Toll-Like Receptor7 (TLR7) Responsiveness Associated with Mitogen- Activated Protein Kinase (MAPK) Activation in HIOEC Cell Line of Oral Squamous Cell Carcinoma
... HIOEC cell lines were eluted in RNase-free water and reverse-transcribed with ReverTra Ace qRT- PCR kit (TOYOBO; Osaka Boseki, ...5¢aagtcccgttattacttgccgg-ttagga-3¢; b-actin for- ward primer, ...
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Control of programmed cell death by Rho-like GTPases-activated signalling cascades in the developing neuron
... RhoA, B and G (Zalcman et ...vivo, b u t they have been show n to inhibit the dow nstream functions of Rho-GTPases (N ishiyam a et ...GTP b inding ...of cell death by ...the activated ...
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Characterization of E2F8, a novel E2F like cell cycle regulated repressor of E2F activated transcription
... Figure 8. Ectopic expression of E2F8 inhibits cell proliferation. (A) Ectopic expression of E2F8 in human TIG3 fibroblasts inhibits cell proliferation. Human TIG3- tert-ecoR fibroblasts were transduced with ...
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The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
... T cell anergy [6,44]. Like IL-10 TGF- β prevents the trafficking of DCs to the lymph nodes ...CD40-activated B cells have gained increasing ...
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B Cell Toll-like Receptors with Respect to the Pathogenesis of Sjögren’s Syndrome
... and B cells ...naive B cells, compared to human naive B cells, express high levels of TLRs and can be activated by TLR ligands (LPS or CpG) without additional help from T cells or BCR ...naive ...
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The Reflected-Shifted-Truncated-Gamma Distribution for Negatively Skewed Survival Data with Application to Pediatric Nephrotic Syndrome
... We show that tomato MPK1/2 and its tobacco homolog, SIPK, associate with a protein complex, however, the Arabidopsis homolog, MPK6, only elutes in low MW fractions and does not appear to be part of a larger protein ...
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Establishing Phenotypic Features Associated with Morbidity in Human T-Cell Lymphotropic Virus Type 1 Infection
... blood cell phenotypes were analyzed with an immunofluorescence procedure recom- mended by Becton Dickinson, modified as ...several cell surface markers (anti- CD45 clone J33, anti-CD62L clone DREG56, ...
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Spontaneous remission in diffuse large cell lymphoma: a case report
... and activated B-cell (ABC) phenotype associated with Epstein–Barr virus (EBV) are potentially linked with a subgroup of patients with propensity for ...
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