Activated Protein C Resistance
Activated protein C resistance in Behcet’s disease
... Behcet ’ s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. ...
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Acquired activated protein C resistance and thrombosis in multiple myeloma patients
... High cumulative risk of thrombotic events in myeloma patients has been already reported [7]. The present study confirmed that myeloma patients treated with thalido- mide and multi-agent chemotherapy are at increased risk ...
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Effects of (pre-) analytical variables on activated protein C resistance determined via a thrombin generation-based assay
... The normahzed activated protem C sensitivity ratio (nAPC-sr) determmed with an assay that quantifies the effect of APC on throrabm formation mitiated via the extnnsic coagulation pathway[r] ...
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Increased Prevalence of Activated Protein C Resistance During Pregnancy may Implicate Venous Thrombo Embolic Disorders as a Common Cause of Maternal Mortality in Nigeria
... Protein C activity was measured using a clot-based assay protein C activator (PCA) assay kit (Diagen UK lot ...standard Activated Partial Thromboplastic Time (APTT) and then the ...
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High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)
... From this, it follows that the relative risk associated with oral contraceptive use is the same for homozygous women äs for women with the other genotypes (under the reasonable assumptio[r] ...
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The Leiden Thrombophilia Study (LETS)
... In this way the role of a deficiency of protein C, protein S or antithrombin and of APC (activated protein C) resistance, elevated von Willebrand factor and factor VIII:c levels, hyperho[r] ...
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The Role of Protein C, Protein S, and Resistance to Activated Protein C in Legg-Perthes Disease
... of protein S deficiency were excluded from the ...the protein C and protein S assays from 4 cases and 3 controls was not obtained, and for the same reason, the APC-R assay was not done for 5 ...
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Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly ...and protein kinase B (Akt) in cultured human endothelial ...of ...
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Anticoagulant synergism of heparin and activated protein C in vitro Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C
... anticoagulant protein C pathway. Activated protein C (APC) is a physiologi- cal anticoagulant whose importance is clearly demonstrated by the thrombotic diathesis associated with ...
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Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis
... H van der Velden PA Reitsma PH Mutation in blood coagulation factor V associated with resistanceto activated protein C Nature 1994,369 64-67 11 HalbmayerWM,HaushoferA,SchonR,FischerM The[r] ...
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Platelet factor 4 impairs the anticoagulant activity of activated protein C
... acquired resistance to APC anticoagulant activ- ity in plasma constitutes the most common laboratory abnor- mality identified in patients with venous ...APC resistance are not well ...from activated ...
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Physiological anticoagulation Resistance to activated protein C and venous thromboembolism
... Genetic risk factors yet to be discovered Inherited APC resistance taken together with deficiencies of protein C, protein S and antithrombin may account for up to 60-70% of cases with fa[r] ...
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Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans
... The protein C anticoagulant pathway regulates this ...Thus, activated protein C (APC) cleaves and inhibits FVa (7, 9, ...cofactor protein S (11). APC and protein S are ...
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Activated protein C in septic shock: a propensity matched analysis
... The efficacy of rhAPC in severe sepsis remains a mat- ter of dispute. Some experts even criticized the Food and Drug Administration’s decision to approve rhAPC [24-26]. The main criticisms were aimed at intercurrent ...
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Activated protein C modulates the proinflammatory activity of dendritic cells
... ° C for 30 seconds, annealing at 59 ° C ∼ 65 ° C for 30 seconds, and elongation at 72 ° C for 1 minute; at the end of these cycles, a further extension was carried out at 72 ° C for 5 ...
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The effect of activated protein C on experimental acute necrotizing pancreatitis
... Quantitative cultures and bacterial identification Tissue specimens taken from mesenteric lymph nodes (MLNs) and one portion of the pancreas with macroscopic necrosis were harvested for culture. Each sample was weighed ...
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Generation of fibrinolytic activity by infusion of activated protein C into dogs
... inactivated protein Ca do not increase the rate of ...of protein Ca sustain rapid blood clot lysis, but neither elevate circulating fibrin-split products nor decrease circulating plasminogen ...of ...
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New players in the sepsis protective activated protein C pathway
... Recombinant activated protein C (aPC) improves the survival of patients with severe sepsis, but the precise molecular and cellular targets through which it mediates this effect remain incompletely ...
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On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies
... supporting activated protein C anticoagulant activity but has little influence on prothrombin ...the protein C anticoagulant pathway by lupus anticoagulants and/or antiphospholipid ...
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The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
... human activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group, administration of APC in sepsis patients leads to significant reduction in plasma IL-6 concentration (3); ...
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