Activating Invasion and Metastasis
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
... neuroblastoma invasion-metastasis ...that activating invasion and metastasis belongs to the cancer hallmarks acquired during the multistep development of human tumors ...neuroblastoma ...
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Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling
... promotes invasion and metastasis in a number of malignancies including NPC cells [24-26, 28-30], we determined whether Stat3 mediates RKIP-inhibiting NPC cell invasion and ...and invasion, as ...
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DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1
... The ERK signaling is a ubiquitous signal transduction pathway that regulates important cellular processes, such as proliferation, migration and invasion [29, 33]. Increas- ing evidences have demonstrated that the ...
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UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3 -catenin pathway
... vivo metastasis assay, suspected lesions of nude mice were sacrificed and dissected under IVIS Lumina II system to detect separated fluorescence ...A metastasis organ was defined as one that showed the ...
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Upregulation of syncytin-1 promotes invasion and metastasis by activating epithelial-mesenchymal transition-related pathway in endometrial carcinoma
... Materials and methods: We analyzed 130 primary EC specimens from Binzhou Medical University to investigate the clinical role of syncytin-1 in EC by using different advanced pathological stages of EC tissues. Kaplan–Meier ...
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Mechanisms of invasion and metastasis in colorectal cancer
... the activating phosphorylation of ERK1/ERK2 was increased, whereas that of p38 MAPKs was reduced ...developed metastasis within 2 years post-surgery compared with healthy mucosa from the same patients ...
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The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
... Acid-sensing ion channels (ASICs) are a proton-gated subgroup of the degenerin/epithelial sodium channel fam- ily of cation channels, and are widely expressed in the ner- vous system [8]. At least six ASIC subunit ...
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FGF8 promotes colorectal cancer growth and metastasis by activating YAP1
... nodes metastasis and worse overall ...enhanced invasion and growth in CRC ...and metastasis in mouse ...and invasion, revealing that YAP1 is required for FGF8- mediated CRC growth and ...
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Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
... EMT, invasion and metastasis of NPC, suggesting that Hes1 plays an important role in triggering EMT in NPC specimens, which was consistent with the results of in vitro studies described ...phenotypes, ...
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MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
... Fig. 3 Over-expression of miR-330-3p induces the ability of tube formation, migration, and invasion in NSCLC cells. a Tube formation assay measuring proangiogenic activity in H460 and H1975 cells; tube formation ...
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Biglycan enhances gastric cancer invasion by activating FAK signaling pathway
... tumor invasion and metastasis of gastric cancer both in vitro and in ...node metastasis, depth of tumor invasion and TNM ...and invasion ability as well as the tube formation ability of ...
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NDRG3 facilitates colorectal cancer metastasis through activating Src phosphorylation
... progression has been reported in a series of studies. 24–26 Liu et al found that NDRG1 attenuates the downstream signaling of c-Src which involves in the p130Cas-CrkIIRac1 pathway, and this leads to suppression of ...
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SLC25A22 promotes proliferation and metastasis by activating MAPK/ERK pathway in gallbladder cancer
... Methods: Immunohistochemistry (IHC) staining analysis and quantitative real-time PCR (qRT-PCR) were conducted to determine the expression of SLC25A22 in GBC tissues. Human NOZ and GBC-SD cells were used to perform the ...
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Identification of FGFR4 activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
... nant action of these mutations, it seems unlikely that germline mutations of this gene would result in normal development. Computational analysis of these TK domain mutations predicted that they would likely result in ...
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SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma
... vascular invasion, TNM stage and BCLC stage, and was an independent risk factor for survival of ...cells invasion, migration and proliferation, also the in vivo testing revealed that SYNJ2BP inhibited tumor ...
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Chemokine 25–induced signaling suppresses colon cancer invasion and metastasis
... cell invasion and ...(CRC) invasion and ...by activating AKT ...CRC metastasis, increased extraintestinal tumor frequency by stimulating CCR9 proteasomal ...and invasion and further ...
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Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
... St Vincent’s Hospital and University College Dublin, Dublin, Ireland Abstract The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the ...
6
Ecosystems of invasion and metastasis in mammary morphogenesis and cancer
... and metastasis, considered as a multistep invasion process, operates on the basis of programs, implicating various cellular activities, namely proliferation, cell-cell adhesion, cell-matrix adhesion, ...
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The impact of hypoxia in pancreatic cancer invasion and metastasis
... Dovepress Hypoxia and pancreatic cancer Sensing and responding to hypoxia The main molecular mechanism by which oxygen homeostasis is maintained in tissues is regulated by the hypoxia-inducible factors (HIFs). 74 This ...
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Ezrin promotes invasion and metastasis of pancreatic cancer cells
... motility, invasion and the abil- ity of anchorage-independent growth, which are all tumor cells ...promote invasion and metastasis in ...gression, invasion and ...
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