activating transcription factor
Myxoma virus attenuates expression of activating transcription factor 4 (ATF4) which has implications for the treatment of proteasome inhibitor–resistant multiple myeloma
... aTF, activating transcription factor; Brea, brefeldin-a; cDna, complementary Dna; MOi, multiplicity of infection; mrna, messenger rna; MYXV, myxoma virus; qPcr, quantitative real-time polymerase ...
11
Activating transcription factor 4 regulates osteoclast differentiation in mice
... Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been ...
13
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
... Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not ...
13
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
... murine in vivo and in vitro HD models and in HD patients. DREAM downregulation was observed early after birth and was associated with endogenous neuroprotection. In the R6/2 mouse HD model, induced DREAM haplodeficiency ...
13
Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy
... whether activating transcription factor 3 (ATF3) is responsible for neuronal injury and a critical molecule that modulates the activation of intracellular protein kinase C epsilon (p-PKCε) and pain ...
10
Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia
... Under physiological conditions, plasma membrane proteins travel to the ER where proper folding is facilitated by ER-resident chaperones. If the ER senses an increased demand for folding capacity, the UPR is activated ...
112
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
... and activating transcription factor 6 (ATF6) implement the ER stress response ...initiation factor 2 (eIF2α), which inhib- its assembly of the 80S ribosome and protein ...pivotal ...
15
Anti cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
... increased activating transcription factor 3 (ATF3) expressions in both protein and mRNA level and activated ATF3 promoter activity, indicating transcriptional activation of ATF3 gene by ...
8
Differential expression of two activating transcription factor 5 isoforms in papillary thyroid carcinoma
... Background: Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays ...
7
Identification potential biomarkers in pulmonary tuberculosis and latent infection based on bioinformatics analysis
... ATF: Activating transcription factor; ATP1A4 : ATPase, Na+/K+ transporting, alpha 4 polypeptide; BATF : Basic leucine zipper transcription factor, ATF-like; BH: Benjamin and Hochberg; ...
10
Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... Kruppel‑like factor 6 (KLF6), activating transcription factor 3 (ATF3) and p21, while down‑regulating the expression of selected oncogenes, including E2F transcription factor 1 ...
8
<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... and activating transcription factor 6 (ATF6), the foremost of which is the PERK-mediated PERK-eIF2 α -ATF4 ...important factor that switches the survival signal to a pro-death ...
15
Metastatic biomarkers in synovial sarcoma
... (BRG-/BRM-associated factor) complexes affect- ing the integration of a tumor suppressor component and consequent SRY (sex-determining region Y)-box 2 (SOX2) activation which stimulates cell proliferation ...
8
Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG 3 cells through endoplasmic reticulum stress
... ATF: activating transcription factor; GRP78: 78-kDa glucose-regulated protein; CHOP: C/EBP homologous protein; XBP1: X-box binding protein-1; PARP: poly (ADP-ribose) polymerase; JNK: c-Jun N-terminal ...
10
Cullin-RING ligases in regulation of autophagy
... Ambra1: activating molecule in Beclin-1-regulated autophagy; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; ATG: autophagy related gene; Bcl-2: B-cell lymphoma 2; ...
14
Uncovering Dual Roles for PERK Signaling During Experimentally Induced Pancreatitis
... Pancreatitis is characterized by inappropriate activation of digestive enzyme precursors, or zymogens, local and systemic inflammation, dysregulation of cellular calcium (Ca 2+ ), and induction of the unfolded protein ...
243
Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways
... Using this method three pathways were upregulated and eight pathways were downregulated (Fig. 4a). Colla- gen formation and extracellular matrix organization pathways were the top two upregulated pathways (Fig. 4a, ...
20
Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... ATF4, activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma-2; ...
14
Herpesviruses and the Unfolded Protein Response
... initiation factor, eIF2α ...bZIP transcription factor Activating Transcription Factor 4 ...of transcription factors and can bind to ATF/CRE-like sequences with a consensus ...
26
The HLA B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients
... ATF4: activating transcription factor 4; BiP/ GRP78: glucose regulated protein; C1QC/C1QB: complement component 1, q subcomponent, C / B chain; CDKN1A: Cyclin-dependent kinase inhibitor 1; EC: ...
10