Activating transcription factor 7
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
... μg/ml in acetate buffer, pH 4, and immobilized to the sensor chip by amine coupling. The surface was activated by injecting a solution of 0.2 M N-ethyl-N-dimethylaminopropyl-carbodiimide (EDC) and 50 mM ...
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Involvement of Template-Activating Factor I/SET in Transcription of Adenovirus Early Genes as a Positive-Acting Factor
... the transcription of early genes E1A and E2 was examined. WT (clone 7) and TAF-I KD (clones 4 and 13) cell lines were infected with HAdV5 at an MOI of 100 and collected at 4 h ...(clone 7) and TAF-I ...
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Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia
... The pancreas develops from the endoderm and is divided into endocrine and exocrine portions (Jennings et al., 2015). The exocrine pancreas represents 98% of the total volume and is composed of two specialized cell types: ...
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Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
... and activating transcription factor 6 (ATF6) implement the ER stress response ...initiation factor 2 (eIF2α), which inhib- its assembly of the 80S ribosome and protein ...pivotal ...
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Activating transcription factor 4 regulates osteoclast differentiation in mice
... BMMs were used for real-time RT/PCR analysis (A) and Western blot (B). (C and D) Differentiated BMMs and tibial sections were subjected to IHC staining for NFATc1. (E) WT BMMs were infected with increasing amounts of ...
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets
... (i.e. transcription factors) or through their ...what transcription factor binding sites are present at the various regulated clusters of genes we analyzed the window from − 300 to + 50 of all ...
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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
... We previously reported that the invasiveness of IR cells is dependent on MRLC dephosphorylation and that diphosphorylated MRLC (PP-MRLC) suppresses invasiveness in IR cells [7]. Therefore, we investigated the role ...
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Identification potential biomarkers in pulmonary tuberculosis and latent infection based on bioinformatics analysis
... ATF: Activating transcription factor; ATP1A4 : ATPase, Na+/K+ transporting, alpha 4 polypeptide; BATF : Basic leucine zipper transcription factor, ATF-like; BH: Benjamin and Hochberg; ...
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Metastatic biomarkers in synovial sarcoma
... ATF2: Activating transcription factor 2; BAF: BRG-/BRM-associated factor; BPSS: Biphasic synovial sarcoma; CDCA2: Cell division cycle A2; CTC: Circulating tumor cells; C-X-C motif: Chemokine; ...
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<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... and activating transcription factor 6 (ATF6), the foremost of which is the PERK-mediated PERK-eIF2 α -ATF4 ...important factor that switches the survival signal to a pro-death ...
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The role of death receptors in ER stress and Inflamation
... 3.2.1 Taxanes Induce Cytokine Production, ER Stress and DR5 Upregulation Taxanes, paclitaxel and docetaxel, have previously been shown to induce cytokines in sporadic studies and have classically been associated with ...
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Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways
... Direct insights into the function of INTS12 come from Drosophila where it is necessary for the spliceosome’s snRNA processing and this function is considered to be canonical [10–12]. Drosophila ’s INTS12 was also impli- ...
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Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans
... of transcription factors (called the retinal deter- mination network, RDN) [17, 20, 21], the subsequent steps that diversify distinct cell types, including rhab- domeric PRs, are likely controlled by diverse ...
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Low pH results in co ordinate regulation of gene expression in oesophageal cells
... Induction of EGR1 mRNA by low pH in oesophageal cell lines EGR1 is an early growth response gene whose expression can be induced by many different stimuli including cytokines, growth factors, DNA damaging agents and ...
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Proteostatic Signaling & Control of Protein Synthesis
... Misfolded proteins are capable of triggering the ISR, and thus translational stalling and eIF2a induced ATF4 expression, through the PERK arm of the UPR. PERK, an ER membrane-embedded kinase activated by dimerization, ...
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Synthetic control devices for gene regulation in Penicillium chrysogenum
... The endogenous elements for the expression cassettes constructed in this study, were amplified by PCR from genomic DNA of P. chrysogenum DS54468. The amdS selection cassette used was described previously [54]. The 138 ...
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<p>Inhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells – Role of Snail, Slug and Twist and Small Molecule Inhibitors</p>
... invasiveness and their increased expressions are associated with malignancy, 26 and silencing these transcription factors was found to decrease invasiveness. Transmembrane inva- sion assay revealed that the ...
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Myxoma virus attenuates expression of activating transcription factor 4 (ATF4) which has implications for the treatment of proteasome inhibitor–resistant multiple myeloma
... aTF, activating transcription factor; Brea, brefeldin-a; cDna, complementary Dna; MOi, multiplicity of infection; mrna, messenger rna; MYXV, myxoma virus; qPcr, quantitative real-time polymerase ...
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Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... Kruppel‑like factor 6 (KLF6), activating transcription factor 3 (ATF3) and p21, while down‑regulating the expression of selected oncogenes, including E2F transcription factor 1 ...
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
... Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. Different subsets of immunoregulatory myeloid populations, including ...
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