Activation loop
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
... To determine the effect of these inhibitors on the activation loop of Aurora A in solution, we repeated our assay in their presence (Figure 2 i, j). Each inhibitor resulted in a large increase in the ...
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Herpes Simplex Virus Requires VP11/12 To Induce Phosphorylation of the Activation Loop Tyrosine (Y394) of the Src Family Kinase Lck in T Lymphocytes
... VP11/12 interacts with Lck in infected T cells. The data presented in the preceding sections establish that VP11/12 is necessary for HSV-induced enhanced phosphorylation of the activation loop tyrosine of ...
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Genetic Analysis of the Relationship Between Activation Loop Phosphorylation and Cyclin Binding in the Activation of the Saccharomyces cerevisiae Cdc28p Cyclin-Dependent Kinase
... and activation loop phosphorylation Cak1p phosphorylates threonine 169 in the activation are independently required for full enzymatic activation loop of the Cdc28p cyclin-dependent ...
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In Vivo Activation of Protein Kinase A in Schizosaccharomyces pombe Requires Threonine Phosphorylation at Its Activation Loop and Is Dependent on PDK1
... the activation loop is conserved with obtain suppressors of the inability of spc1::ura4 cells to respect to PDK1 substrates but the protein does not grow on medium containing gluconate as a sole ...
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Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
... R eceptor tyrosine kinases (RTKs) wield exquisite control over cell differentiation, fate, metabolism and homeostasis. Dysregulation of RTK signalling plays a significant role in the pathogenesis of disease conditions ...
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Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop
... on density functional theory (DFT) has been employed to determine conformations of the methane-thiosulfonate spin label (MTSL) attached to a fragment extracted from the activation loop of Aurora-A kinase. ...
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A secondary RET mutation in the activation loop conferring resistance to vandetanib
... A thermal shift assay in the presence or absence of drug sug- gested that the S904F mutation is less able to bind vandetanib. The co-crystal structure of RET kinase in complex with vandetanib indicates that the mutated ...
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MAP Kinase Regulation of the Candida albicans Pheromone Pathway
... ABSTRACT We investigated the relationships of the Cek1 and Cek2 mitogen- activated protein (MAP) kinases and the putative MAP kinase phosphatase Cpp1 in the mating process of Candida albicans. Mutants of the CPP1 gene ...
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Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix
... the activation loop diverges from that of an active kinase and is disordered between aa281 and ...ordered activation loop, similar to that of the canonical kinase PKA (Fig 3B and C; Knighton ...
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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
... the activation loop and in stabilising helix αC, we speculated that lack of TSS motif phos- phorylation would alter the substrate affinity/selectivity of the Aurora:INCENP ...
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A Mitotic Cascade of Nima Family Kinases Nercc1/nek9 Activates the Nek6 and Nek7 Kinases
... the activation of the Nek6/7 kinases and to define the regulation of the endog- enous ...the activation loop of both Nek6 and Nek7 and activates these kinases in vitro and in ...
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PTP1B: a new therapeutic target for Rett syndrome
... recombinant PTP1B substrate–trapping mutant (PTP1B-D181A), which forms a stable complex with the phosphory- lated substrate, and demonstrated that PTP1B-D181A, but not WT PTP1B, binds to TRKB in mouse brain lysates (19). ...
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Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
... signaling loop and drive ...the activation loop [7], which is in contrast to several prominent oncogenic mutations, such as BRAF V600E and ALK R1275Q,moreover,the hotspot mutation, L858R [11] in EGFR ...
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Decreased expression of LKB1 predicts poor prognosis in pancreatic neuroendocrine tumor patients undergoing curative resection
... 11,12 LKB1 is a highly conserved serine/threonine kinase that directly phosphorylates a threonine residue at the activation loop of 14 kinases in the AMPK (AMP-activated kinase)[r] ...
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Narrative Social Work Practice for HIV/AIDS Clients
... In this section, the measurement methods are discussed in light of Y’s case. The effectiveness of this transformation process can be explained in terms of the activation of the differentiation force between pre- ...
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Targeting TACE dependent EGFR ligand shedding in breast cancer
... The ability to proliferate independently of signals from other cell types is a fundamental characteristic of tumor cells. Using a 3D culture model of human breast cancer progression, we have delineated a ...
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TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes
... Although our study showed a discrepancy between expression of sXBP1 and of other UPR genes, this does not necessarily contradict the fi ndings of previous studies published on this theme. Abnormalities of UPR were still ...
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Evaluation of moment-force ratio of two different loops: A finite element study.
... the loop configuration to provide a moment to prevent the root apices of the teeth from moving in a direction opposite to that of their crowns (uncontrolled ...during activation of spring (distal tipping of ...
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Unusual structure of the human immunodeficiency virus type 1 trans-activation response element.
... trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-activating-responsive hairpin: a quantitative analys[r] ...
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Effect of a Dual Loop Thermal Management Arrangement with a Single Module Radiator on Vehicle Power Consumption
... dual loop VTMS currently in development by Fiat on a Fiat Punto with a ...dual loop setup was to attempt to reduce the fan and compressor power consumption and consequently improve the vehicle fuel ...dual ...
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