acute T cell leukemia
Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia
... from T-ALL patients ...eight T-ALL patients are presented (Table 1), consisting of one with refractory disease (ALL-31), one with chemo-resistant disease who died early (ALL-44), three with early relapse ( ...
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Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
... of T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma lead to the investigation and development of 9-beta-D-arabinosylguanine (ara-G) and was innately guided by the current ...
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Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia
... The authors would like to thank the donors for agreeing to have their cells used for research, and the clinical teams from Hôpital A Trousseau and Hôpital R Debré in Paris, for their dedicated aid in collecting samples. ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... rearrangements (8/17) than for beta rearrangements (3/17). This also contrasts with the only occasional rearrangement of immunoglobulin (Ig) heavy chains (3/25) in T-ALL. However, in pre-B ALL the pattern of gamma ...
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Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia
... and acute renal failure (ARF) before the initiation of ...of cell turnover (eg, Burkitt’s lymphoma) and has only rarely been described in the pediatric ...
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T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ...CD3- ...
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CD40 ligation reverses T cell tolerance in acute myeloid leukemia
... antigen-specific T cell responses can be generated in hosts harboring a variety of solid malignan- cies, but are subverted by immune evasion mechanisms active within the tumor ...regulate T ...
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Induction of human B cell antigens in non T cell acute lymphoblastic leukemia
... non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B ...Non-T cell ALL lines and tumor cells isolated from patients with non-T ...
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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM − / − thymic lymphomas [4 – ...murine T-ALLs retain at least one ...
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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
... in T-ALL cases (49, ...B cell lymphoma (DLBCL) that promotes malignant progression in part by constitutive NF-κB activity (29, ...Jurkat T-ALL cell lines, we sequenced the MYD88 gene in these ...
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Phenothiazines induce PP2A mediated apoptosis in T cell acute lymphoblastic leukemia
... suppressed T-ALL cell growth in the presence of GSI (the +GSI composite Z score) and the extent to which this suppression exceeded that observed in the absence of GSI (the so-called 2-assay score; Figure ...
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Protein kinase inhibitors for acute leukemia
... Protein kinases are conventionally divided into five clas- ses: protein tyrosine kinase, protein serine/threonine kinase, tryptophan protein kinase, histidine protein kin- ase and protein aspartyl/glutamoyl kinase. It ...
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
... of T-ALL. Within the high risk group of early T-ALL patients the recently identified subgroup of Early T-cell precursor (ETP-) ALL has been characterized by an immature immunophenotype with a ...
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T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia
... for T lineage cells and gamma- and/or beta-chain gene rearrangement does not appear essential for alpha-chain gene rearrangement, at least in B-precursor leukemic ...
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SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
... 141 leukemia/lymphoma cell lines of T-, B- and myeloid cell origin to detect SET-NUP214 positive ...A T-ALL cell line LOUCY (1/43 T cell lines tested) and an AML ...
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The molecular basis of T cell acute lymphoblastic leukemia
... of T-ALL ...of T-ALL in transgenic mice expressing TAL1 in developing thymocytes (62, ...In T-ALL cells, TAL1 forms pri- marily inactive transcriptional complexes that contain E proteins and the LMO ...
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Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) represents expansion of cells arrested at specific stages of thymic development with the underlying genetic abnormality often determining the ...
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...B cell line (HABL) was established. ...
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... Therapy-related acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...therapy-related acute ...
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<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... Lymphoblastic Leukemia (GBTLI-ALL 99/09) or to ALL Berlin- Frankfurt- Münster (BFM-ALL 95 and 2002) ...and T-cell phenotype of both proto- ...
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