Acyl-CoA oxidase
Large deletion of the peroxisomal acyl CoA oxidase gene in pseudoneonatal adrenoleukodystrophy
... We have cloned the cDNA encoding human peroxisomal acyl-CoA oxidase, the first enzyme in the peroxisomal beta-oxidation of very long chain fatty acids. Its nucleotide sequence was found to be highly ...
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Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyltransferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet
... 1). acyl-CoA oxidase catalyzes the first step of peroxisomal fatty acid b-oxidation, and its gene expression is regulated by the peroxisome proliferators- activated receptors (PPARs) ...medium-chain ...
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Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl CoA oxidase 1 deficient fibroblasts
... in acyl-CoA oxidase 1 (ACOX1) gene, which encodes the first and rate-limiting enzyme in peroxisomal β-oxi- dation pathway ...peroxisomal acyl-CoAs β- oxidation and, because causing ...
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Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
... Interestingly, the algal protein showed slightly broader activity toward different acyl-chain lengths than the plant protein (Figure 6b). This may at least partly explain why a strong phenotype can already be ...
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
... (CAT), acyl-CoA oxidase 1 (AOX), and 3-ketoacyl-CoA thiolase (THL) were stud- ied, to get an insight into the biogenesis and functioning of peroxisomes in the diseased ...
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PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice
... For example, mice lacking expression of the peroxisomal acyl-CoA oxidase AOX gene showed massive accumulation of very-longchain fatty acids in hepatocytes, severe microvesicular steatosi[r] ...
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Non-esterified fatty acids in the ovary: friends or foes?
... ACO: Acyl CoA oxidase; ALA: α -linolenic acid; AMPK: 5 ′ adenosine monophosphate-activated protein kinase; ATF4: Activating transcription factor 4; cAMP: Cyclic adenosine monophosphate; CCND2: Cyclin ...
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Zellweger spectrum disorders: clinical overview and management approach
... Especially Acyl-CoA oxidase type 1 (ACOX1) deficiency and D-bifunctional protein (DBP) deficiency show great overlap and in some cases, especially in the neonatal-infantile and childhood period, can ...
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Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
... The frozen liver was homogenized in buffer A (3 mmol/ L Tris/HCl, pH 7.2, 1 mmol/L EDTA, 1 mmol/L dithio- threitol, 25 μmol/L ALLN (N-acetyl-leucyl-leucyl-norl-- leucina, a calpain and cathepsin inhibitor), 100 μmol/L ...
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Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?
... ACBP: Acyl binding protein; ACOX: acyl-CoA oxidase; ATCC: American Type Culture Collection; BSA: Fatty acid-free bovine serum albumin; CPT 1: Carnitine palmitoyl transferase 1; DAG: ...
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Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol induced fatty liver diseases in mice
... Abbreviations ACC: acetyl-CoA carboxylase; ACO: acyl-CoA oxidase; AdipoR1, adiponectin receptor 1; AdipoR2, adiponectin receptor 2; AFLD: alcoholic fatty liver disease; ALT: alanine tran[r] ...
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Vol 70, No 4 (2018)
... (Acyl-CoA oxidase 1, catalase, alpha-1,3 glucan synthase, mitogen-activated protein kinase HOG1, isocitrate dehydrogenase 1, triose-phosphate isomerase, cytochrome P450, G-protein α subunit, exo- ...
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The role of Fyn kinase in CRH regulation of energy homeostasis
... α/β hydrolase domain-containing protein-5 adenylyl cyclase acetyl-CoA carboxylase acyl-CoA oxidase adrenocorticotropin hormone protein kinase B AMP-activated protein kinase Analysis of v[r] ...
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How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?
... fatty acyl-CoA esters, a reaction which is catalysed by acyl-CoA synthetases ...fatty acyl-CoA substrates are accepted by ABC subclass D protein (ABCD) transporters, cleaved by ...
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Emerging role of lipid metabolism alterations in Cancer stem cells
... ACADM: Acyl-CoA dehydrogenase medium chain; ALDH1: Aldehyde dehydrogenase isoform 1; CoA: Acetyl coenzyme A; CSCs: Cancer stem cells; EGFR: Epidermal growth factor receptor; EMT: Epithel[r] ...
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2 methylbutyryl CoA dehydrogenase deficiency associated with autism and mental retardation: a case report
... Our patient exhibited developmental abnormalities com- patible with autism, thus expanding the clinical spectrum of this rare biochemical disorder. Developmental regres- sion has so far not been observed in SBCADD. ...
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Mitochondrial trifunctional protein deficiency Catalytic heterogeneity of the mutant enzyme in two patients
... We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin ...
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Deciphering the gene expression profile of peroxisome proliferator activated receptor signaling pathway in the left atria of patients with mitral regurgitation
... The PPAR transcriptional regulatory complex controls the expression of fatty acid utilization genes by bind- ing to specific promoter DNA response elements with its heterodimeric partner, the retinoid X receptor, and ...
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Functions of rat acyl-CoA synthetases in bacteria and mammalian cells
... only some lipid metabolic pathways. For example, when human fibroblasts are incubated with 10 µM triacsin C, oleate (C18:1) incorporation into both TAG and CE decreases 91%, while incorporation into PL is not impaired, ...
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Malonyl-CoA metabolism in skeletal muscle
... synthase was reduced to 1 m unit per assay and accordingly lengthened the incubation time to 2 h, but still observed sufficient lack of linearity to preclude the use of internal standards. However the use of internals ...
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