Adenosine A(2A) receptor
Adenosine A<sub>2A</sub> receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction
... of adenosine A 2A receptor, could be beneficial for preventing cardiac dysfunction due to hypertension associated with myocardial infarction ...
10
Circadian Variation of Antinociceptive Effect of Adenosine and Adenosine A1 Receptor Agonists, N6-Phenylisopropyl Adenosine and 2-Chloroadenosine, in Mice
... 11). Adenosine also regulates pain transmission by actions at spinal, supraspinal and peripheral sites through the activation adenosine A1 receptors and may play an important role in inflammatory and ...
5
The effect of receptor density on the binding and functional properties of the human adenosine A1 receptor
... The adenosine Ai agonists GR190178, GR161144 and GR162900 have a lower efficacy than full agonists such as CHA and NECA as they are unable to stimulate maximum responses in a number of functional measurements of ...
321
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction
... et al. 2010) further argues for a direct ability of A2AR on microglia cells to control LPS-induced neuroinflammation. However, it remains to be determined if the A2AR mainly control the chemotaxis or the activation of ...
12
Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy
... vaso-obliteration and hypoxia-induced revascularization (Zhang et al. 2015). This proposal is further substantiated by a recent large prospective phase III clinical study “Caf- feine Therapy for Apnea of Prematurity” ...
13
Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine
... vascular system expresses A 2A receptors [19]. In keeping Fig. 4 Effect of i.v. CGS21680 on the dural diameter. CGS21680 (10 μ g/kg) was injected followed by an injection of vehicle and varying doses of ...
10
A systems pharmacology approach to the adenosine A1 receptor
... Ordinary differential equation (ODE) models were constructed from biological reaction schemes by assuming the laws of mass action kinetics. These models were written and implemented in Matlab 2012a (Mathworks, Cambridge, ...
246
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... of adenosine. Adenosine is found at immunosup- pressive concentrations within the tumor microenvironment (18) and can be generated from extracellular ATP in a stepwise manner by the ectoenzymes CD39 and ...
14
A<sub>2A</sub> adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE–knockout mice
... a nonspecific adenosine agonist, by infusing the drug into the coronary perfusate through an injection port directly proximal to the aortic cannula. The infusion rate was con- trolled to a maximum of 1% of CF with ...
10
Adenosine signaling promotes hematopoietic stem and progenitor cell emergence
... as adenosine, ADP, and ATP) exhibit specific extracellular signaling activity in the regulation of many diverse functions including auto- regulation of blood flow, cell proliferation and differentia- tion, and ...
16
Adenosine Receptors Machinery and Purinergic Receptors in Rat Primary Skeletal Muscle Cells
... is adenosine receptors, which are divided into A 1 , A 2A , A 2B and A 3 adenosine receptors based on pharmacology and coupling to cAMP ...encoding adenosine and purinergic receptors highly ...
16
A protective role for the A1 adenosine receptor in adenosine dependent pulmonary injury
... of adenosine are increased in the lungs of asthmatics (3), in which elevations correlate with the degree of inflammatory insult ...that adenosine may play a provocative role in asthma and COPD (5, ...6). ...
10
Adenosine formed by 5′ nucleotidase mediates tubuloglomerular feedback
... of adenosine, which causes glomerular ...hypothesis. Adenosine activity was manipulated by microperfusing nephrons with adenosine A1 receptor blocker, A1-ago- nist, or 5′-nucleotidase ...
11
Effect of agonists of adenosine receptors on inflammatory markers in human Muller cells
... adenosine receptors. Recent studies have shown that inflammation plays a major role in the pathogenesis of diabetic retinopathy 29,30 . Several inflammatory markers have been reported which might be involved in ...
6
Adenosine metabolism and murine strain–specific IL 4–induced inflammation, emphysema, and fibrosis
... on adenosine accumulation, ADA activity, and adenosine receptor expression in these ...in adenosine metabolism in C57BL/6 and Balb/c mice and dem- onstrate that these differences contribute to ...
11
The Adenosine Receptor Agonist 5’ N Ethylcarboxamide Adenosine Increases Glucose 6 Phosphatase Expression and Gluconeogenesis
... of adenosine A2 receptors increases cAMP levels, which are thought to mediate NECA-induced increases in serum glucose levels [7] because increases in cAMP production activate glycogen degradation ...
5
Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
... CD73-converted adenosine regulates platelet reactivity, we added the aforementioned inhibi- tors to MSC–platelet ...CD73-mediated adenosine generation causes platelet inhibition ...CD73-mediated ...
17
Analgesic Effect of a Single Dose of Adenosine for Neuropathic Pain Reduction in a Patient with Primitive Neuroechtodermal Tumor
... and adenosine analogs in animal models have been known for more than 10 ...years. Adenosine receptors of the A 1 -subtype are associated with a modulatory effect on pain transmission at spinal cord ...that ...
5
The inhibition of human lung fibroblast proliferation and differentiation by Gs coupled receptors is not predicted by the magnitude of cAMP response
... Expression of GPCR was determined in HLF using high density, 384-well GPCR TaqMan arrays as previously described [20]. RNA from 4 fibroblast donors (all from healthy/non-smoker Caucasian donors) was isolated using the ...
13
Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
... Cyclic Adenosine Monophosphate Analogs Stimulate Vascular Endothelial Growth Factor mRNA Expression Because adenosine receptor agonists increased cAMP levels and VEGF mRNA expression in [r] ...
13