Adenylyl cyclase (AC activity)
Sgt1p Contributes to Cyclic AMP Pathway Activity and Physically Interacts with the Adenylyl Cyclase Cyr1p/Cdc35p in Budding Yeast
... positions 1 to 133, 168 to 219, and 220 to 395. The compatibility of the individual sequences and sequence alignments with known three-dimensional (3D) pro- tein structures was tested by using the sequence-structure ...
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase
... of adenylyl cyclase by fors- kolin (Seamon and Daly, 1981) and inhibi- tion of phosphodiesterases by IBMX (Kramer et ...all adenylyl cyclases. Fur- thermore, the drug affects the activity of ...
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Digoxin reduces beta adrenergic contractile response in rabbit hearts Ca(2+) dependent inhibition of adenylyl cyclase activity via Na+/Ca2+ exchange
... functional activity of Gs did not differ between the two groups, basal adenylyl cyclase activity and the maximal ac- tivity stimulated by isoproterenol, sodium fluoride, and forsko- lin ...
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Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy In heart failure, only the impairment in adenylyl cyclase activation progresses
... in adenylyl cyclase associated with a decrement in Gs functional activity in cardiac sarcolemma from animals with pressure overload-induced hypertrophy and heart ...stimulated adenylyl ...
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5-25-2015 The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb
... pled adenylyl cyclase mediates the detection of odorants and pheromones by the MOE through sequential activation of critical components of the olfactory signal transduction cascade [4, 6, ...
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Role of adenylyl cyclase S674 in central and forearm vasomotor control
... this adenylyl cyclase variant would exert differential beta-adrenergic control of cardiac or vascular function in response to excitatory or inhibitory ...this AC variant group (Gros, ...
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Adenylyl cyclase dependent axonal targeting in the olfactory system
... in adenylyl cyclase 3 (adenylate cyclase 3)-deficient ...the cyclase depletion leads to the prevention of neuropilin 1 (Nrp1) expression in olfactory sensory neuron axonal ...cascade, ...
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Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity
... an adenylyl cyclase (AC) encoded by the rutabaga (rut) gene and a phosphodiesterase (PDE) encoded by the dunce (dnc) gene are preferentially expressed in the MBs, and play critical roles in olfactory ...
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[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells
... sAC is the predominant form of adenylyl cyclase in mam- malian sperm [1-3]. The direct activation of sAC by bicar- bonate in sperm provides a mechanism for generating the cAMP required for fertilization, ...
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Modulation of adenylyl cyclase by GABAB receptors in vitro and in vivo
... th e selectivity of 3-APA betw een th e stu d y by Scherer (com pletely selective) an d th e p re s e n t stu d y (poorly selective). T his m ig h t now be ex p lain ed in term s of different num bers of viable receptors ...
257
Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
... of adenylyl cyclase − cyclic adenosine monophosphate (AC − cAMP) signaling ...of AC − cAMP signaling in mood disorders, with a special focus on PKA, because of the interesting observation that ...
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An Arabidopsis thaliana leucine rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens
... Arabidopsis AC candidates belong to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family, which are involved in disease resistance and are believed to bind to pathogen-associated proteins (McHale et ...
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The Effects of Hydrostatic Pressure on A1 Adenosine Receptor Signal Transduction in Brain Membranes of Two Congeneric Marine Fishes
... Incubation of the brain membrane preparations from the two Sebastolobus species at 48.1 MPa and 5°C does not result in the loss of basal adenylyl cyclase activity or sensitivity to modul[r] ...
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A G-Protein β Subunit Required for Sexual and Vegetative Development and Maintenance of Normal Gα Protein Levels in Neurospora crassa
... be ac- counted for by loss of a G␣ ...regulate adenylyl cyclase (CR-1) activity and protein levels, ...PKA-C activity promotes aerial hypha formation and apical extension while ...
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The role of cyclic AMP and K+ channels in mediating vasorelaxation induced by prostacyclin analogues and other agonists of Gs-coupled receptors
... its stable analogues, to my knowledge only one group has studied the effect of PKA inhibitors on relaxation mediated by these agents, and none using inhibitors of adenylate cyclase. In these previously reported ...
247
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
... [12,13]. Adenylyl cyclase beta (ACβ), an orthologue of the mammalian soluble adeny- lyl cyclase, is thought to be the only enzyme by which asexual blood stage malaria parasites synthesise cAMP and ...
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Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism
... We evaluated G-proteins that are components of adenylyl cyclase AC signal transduction in erythrocyte and lymphocyte membranes from 26 family history positive FHP nonalcoholic and 26 fam[r] ...
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Regional myocardial downregulation of the inhibitory guanosine triphosphate binding protein (Gi alpha 2) and beta adrenergic receptors in a porcine model of chronic episodic myocardial ischemia
... protein-adenylyl cyclase pathway in the ...protein-adenylyl cyclase pathway occur in the setting of chronic episodes of reversible ...number, adenylyl cyclase activity was ...
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The Effects of Topical Adenosine Agonists (Limonene) on Induced Ocular Hypertension in Rabbits
... AR on endothelial and smooth muscle cells is responsible for adenosine-induced vasodilation [7]. Limonene is a major aromatic compound in essential oils extracted from citrus rind obtained from oranges, grapefruits, and ...
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Overexpression of Gs alpha protein in the hearts of transgenic mice
... Alterations in beta-adrenergic receptor-Gs-adenylyl cyclase coupling underlie the reduced catecholamine responsiveness that is a hallmark of human and animal models of heart failure. To study the effect of ...
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