Adherens junctions
Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
... by adherens junctions, in which aPKC , N- cadherin,  -catenin and ZO-1 are localized (Chenn and Walsh, 2002; Manabe et ...the adherens junctions, together with the abnormalities in the ...
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Kaposi's Sarcoma-Associated Herpesvirus Disrupts Adherens Junctions and Increases Endothelial Permeability by Inducing Degradation of VE-Cadherin
... the adherens junctions were ...disrupted adherens junctions ...of adherens junctions correlated with the increased permeability of the endothelial ...of adherens ...
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Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry
... to adherens junctions in epithelial cells, are these gD receptors accessible for binding to virus? In this study, we used Madin-Darby canine kidney (MDCK) cells to examine the effects of junctional ...
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Adherens junctions connect stress fibres between adjacent endothelial cells
... Figure 7 Effect of tumour necrosis factor (TNF)- a and confluence on discontinuous adherens junctions, stress fibres and focal adhesions. Confluent unstimulated human umbilical vein endothelial cells ...
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Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
... at adherens junctions during cell shape change, suggesting that Diaphanous helps coordinate adhesion and contractility of the underlying actomyosin ...stabilizing adherens junctions and ...
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Drosophila MAGI interacts with RASSF8 to regulate E Cadherin based adherens junctions in the developing eye
... Regulated cell-cell adhesion is crucial for correct formation of the interommatidial lattice. For example, IPC rearrangement requires the careful modulation of adherens junctions (AJs) (Tepass and Harris, ...
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Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical basal polarity establishment
... spot adherens junctions (SAJs) (F-J; arrows in A ′ -E ′ show position of sections) or ...bicellular junctions); ...tricellular junctions (TCJs) (G ′ , red ...bicellular junctions by ...
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Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells
... Results: Here, we show that the activity of the monomeric GTPase Rac1 contributes to inhibition of E-cadherin-mediated cell-cell adhesion in pancreatic carcinoma cells. Stable expression of constitutively active ...
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Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis
... endothelium, adherens junctions may be important in directing the morphogenesis of the vasculature during embryonic development and when angiogenesis occurs in the ...
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Microtubule dependent apical restriction of recycling endosomes sustains adherens junctions during morphogenesis of the Drosophila tracheal system
... Epithelial remodelling is an essential mechanism for organogenesis, during which cells change shape and position while maintaining contact with each other. Adherens junctions (AJs) mediate stable ...
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Remodeling of Endothelial Adherens Junctions by Kaposi's Sarcoma-Associated Herpesvirus
... via adherens junctions, cellular structures that mediate tight adhesion be- tween neighboring cells ...of adherens junc- tions changes normal epithelial cells into invasive cells, and defective ...
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Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability
... Increased vascular permeability is an early event characteristic of tissue ischemia and angiogenesis. Although VEGF family members are potent promoters of endothelial permeability the role of placental growth factor ...
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Rho1 regulates Drosophila adherens junctions independently of p120ctn
... We extended previous analyses of Rho1 localization (Magie et al., 2002; Padash-Barmchi et al., 2005). It is dynamic, with Rho1 accumulating at different subcellular sites in distinct cell types, some consistent with ...
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The multifaceted roles of FOXM1 in pulmonary disease
... AJs: Adherens junctions; ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome; ASMC: Airway smooth muscle cell; AURKB: Aurora B kinase; BICD2: Bicaudal D2; BMPCs: Bone marrow-derived progenitor ...
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Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
... barrier. Adherens junctions depend on the associations of p120, E-cadherin, β-catenin and α-catenin, which act as trans- ducers, mediating the transduction of shear-stress signals into vascular endothelial ...
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Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
... tight junctions (TJs) that interconnect the endothelial and epithelial cells, ...and adherens junctions in the brain capillary endothelial cells and in the CP epithelial ...
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The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo
... Recently, the strong paracrine property of MSC has been considered to be the principal mechanism for maintaining function in damaged organs [8, 9]. The pulmotrophic factor, hepatocyte growth factor (HGF), which plays an ...
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Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression
... Cell surface transmembrane tyrosine kinase receptors modulate the adhesion complex by phosphorylation, as demonstrated for the EGFR [105]. This work showed that the EGFR is associated with the E-cadherin-β-catenin ...
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Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells
... Some of the rapamycin targets are GTPase activity related, such as downregulated EPHA2 and upregulated ARF6 and RALA. GTPases are involved in cell adhesion migration and oncogenic transformation. For example, EphA2 is ...
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The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications
... E-cadherin, the main cell-cell adhesion molecule in epithelia, plays pivotal roles in the suppression of tumor cell migration and metastasis and is also a key molecular player in the EMT process [30]. Several mechanisms ...
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