Adipocyte Differentiation
STEM OF Elsholtzia splendens INHIBITS ADIPOCYTE DIFFERENTIATION BY REGULATING PPARγ and C/EBPα GENE EXPRESSION IN 3T3-L1 CELLS
... Due to the recently increased interest in natural products with anti-obesity properties, many studies are being conducted to identify flavonoids that influence adipocyte differentiation. E. splendens ...
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The brown adipocyte differentiation pathway in birds: An evolutionary road not taken
... in adipocyte differentiation medium (ADM) containing horse serum (HS), LBM gave rise to a cell population which contained numerous small Oil-red positive lipid droplets (Figure 1a, c), which did not fuse ...
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Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells
... Obesity is characterized at the cellular level by an in- crease in adipogenesis [18]. 3 T3-L1 cells have been used extensively as a cell culture model to study the molecu- lar control of adipogenesis [19]. During 3 T3-L1 ...
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A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation
... induced adipocyte differen- tiation, because evidence supporting a key role for PPAR ␥ in adipogenesis has been based on gain of function experiments with this ...
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KLF13 promotes porcine adipocyte differentiation through PPARγ activation
... In the present study, we found that KLF13 is an early pro-adipogenic factor. In order to investigate the re- gulatory manner of KLF13 and identify its targets, we performed the gain-of function and loss-of function ex- ...
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Bisphosphonates and adipogenesis: Evidence for alendronate inhibition of adipocyte differentiation in 3T3 L1 preadipocytes through a vitamin D receptor mediated effect
... study adipocyte differentiation ...adipose differentiation of 3T3-L1 through the in- hibition of the key adipogenesis transcription factors, such as peroxisome proliferator-activated receptor-gam- ma ...
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Antioxidant, anti adipocyte differentiation, antitumor activity and anthelminticactivities against Anisakis simplex and Hymenolepis nana ofyakuchinone A from Alpinia oxyphylla
... during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor γ (PPAR γ ...anti-adipocyte differentiation, antitumor activity, ...
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Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
... marrow adipocyte numbers (data not ...of adipocyte colonies in CFU-A assays and knocking down Flt1 reduced the number of adipocyte colonies compared with con- trols (Figure 6, E and ...
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Adipogenic miRNA and Meta-signature miRNAs involved in human adipocyte differentiation and obesity
... the adipocyte differentiation process, we used microarray technology to monitor miRNA levels in human adipose-derived mesenchymal stem cells (hMSCs-Ad), human stromal vascular cells (SVCs) and ...
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Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity
... the differentiation of rat preadipo- cytes was accompanied by an increased expression of TSHR ...between adipocyte differentiation and TSHR expression was investigated in murine 3T3-L1 ...
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The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain.
... exhibit adipocyte morphology, to induce glycerophosphate dehydrogenase activity, and to induce differentiation-dependent mRNA for adipocyte ...blocked differentiation, thus mapping at least ...
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MicroRNA 188 regulates age related switch between osteoblast and adipocyte differentiation
... Figure 7. MiR-188 inhibits osteogenic differentiation of BMSCs. (A) qRT-PCR analysis of the relative levels of miR-188 expression in BMSCs cultured in osteogenesis induction medium (300 ng/ml BMP-2, 50 μg/ml ...
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Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro
... In diet-induced obese C57BL/6 mice, T-AG17 does not induce weight loss, as we had originally hypothe- sized. Interestingly, the DNP uncoupler does induce weight loss at thermoneutrality (30 °C) [10], which differs from ...
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Role of Foxa 2 in adipocyte metabolism and differentiation
... of adipocyte differentiation is the focus of extensive research and has identified a cascade of transcription factors that are responsible for this con- version ...in adipocyte differentiation ...
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Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake
... tion, differentiation, and glucose ...increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes ...
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Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue
... brown adipocyte differentiation and thermogenesis (such as ucp1, tbx15 , bmp7, and cidea ), as well as phosphorylation of AMPK, was increased in WAT (but not in BAT) of RH-fed ...
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Trapa japonica Flerov Extract Attenuates Lipid Accumulation through Downregulation of Adipogenic Transcription Factors in 3T3 L1 Cells
... Reducing lipid accumulation through the inhibition of adipocyte differentiation may play a crucial role in preventing obesity. Many researchers have investigated novel anti-adipogenic agents as potential ...
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Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
... of adipocyte biology is exemplified by patients with Cushing’s syndrome who develop florid, but reversible central ...for adipocyte differentiation (Hauner et ...
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Original Article Gene Expression Profiling Reveals a Diverse Array of Pathways Inhibited by Nuclear Receptor SHP during Adipogenesis
... differentiation in preadipocytes [8]. More recently, new transcription factors or transcriptional pathways are also implicated in the control of adipogenesis. Extracellular inhibitors, including cytokines, lipid ...
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Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle
... the adipocyte determi- nation and differentiation factor 1 (ADD1/SREBP-1c) ...in adipocyte differentiation ...the differentiation process ...
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