Adipose tissue dysfunction and oxidative stress
Glucotoxicity, Protein Glycation and Adipose Tissue Dysfunction
... in adipose tissue DPP4 will have a strong impact: it stimulates lipid accumulation and PPARγ expression and it may be involved in remodeling and inflammation of adipose ...
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Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
... Adipose tissue can be divided into two major types: white adipose tissue (WAT) and brown adipose tissue (BAT), both of which have different physiological roles ascribed to ...
12
Hypoxia and adipose tissue function and dysfunction in obesity
... more tissue-specific than HIF-1, and it is suggested that it may respond to different levels of O 2 ...in adipose tissue of obese mice (72, ...in adipose tissue show reduced weight gain ...
21
Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
... Adipose tissue can be divided into two major types: white adipose tissue (WAT) and brown adipose tissue (BAT), both of which have different physiological roles ascribed to ...
12
Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
... white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative ...brown adipose tissue (BAT) during obesity, and ...
12
Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction
... DNA methylation is the predominant epigenetic modification in vertebrates (87). A methyl group from S-adenosine methionine is attached to the 5’ position of a cytosine residue within a cytosine-phosphate-guanine (CpG) ...
50
Mitochondrial dysfunction and oxidative stress in aging and cancer
... cONcLUsIONs There is much evidence that the normal aging and carcinogenesis are multistep processes, which can be induced by ROS (Figure 4). Mitochondria generate ROS during normal metabolism. ROS, in turn, may have an ...
27
Oxidative stress and mitochondrial dysfunction in Kindler syndrome
... Abstract Background: Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering, photosensitivity, premature aging, and propensity to skin cancer. In spite of the knowledge underlying ...
10
Regulation of endoplasmic reticulum stress in adipose tissue metabolism
... 2 tissue culture flask (T75) (corning, UK) containing 15 mL primary adipocyte growth media that had been pre-incubated in a 37 C, 5 % CO 2 humidified incubator for 15 ...
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Mitochondrial dysfunction, oxidative stress, and major depressive disorder
... The neuroprotective effect of topiramate was studied in young adult male Wistar rats in status epilepticus triggered by pilocarpine to resemble human temporal lobe epilepsy. 29 In this study, the effect of large ...
7
Mitochondrial dysfunction and oxidative stress in metabolic heart disease
... cardiomyocyte relaxation, is also oxidant-sensitive. Clearance of cytosolic calcium into the endoplasmic/sarcoplasmic reticulum (SR/ER) requires active uptake by the SR/ER Ca 2+ ATPase (SERCA). Sulfonylation of SERCA by ...
170
Obesity, estrogens and adipose tissue dysfunction : implications for pulmonary arterial hypertension
... of adipose tissue to expand and store ...for adipose expansion is determined by both genetic and environmental factors and once the adipose tissue expansion limit is reached, ...
74
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
... tive stress, and double-strand DNA breaks ...age-related dysfunction of adipocyte progenitors and metabolism, as elegantly demon- strated in mice expressing a p16INK4a promoter–driven inducible caspase-8 ...
10
Early alterations in vascular contractility associated to changes in fatty acid composition and oxidative stress markers in perivascular adipose tissue
... While at this stage (3 weeks of treatment) the vascular smooth muscle response was still unaffected, alterations in the vascular relaxant properties dependent on the PVAT were already evident. These results should ...
9
Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
... ti-organ tissue injury (Created by ...with oxidative stress and inflammation leading to multi-organ tissue injury in the ...and oxidative stress [68] [93] ...the tissue ...
20
Redox processes and oxidative stress in cell and tissue damage
... The cause of most neurodegenerative diseases is still to be discovered. One likely contributor is oxidative stress which has been found to be elevated in both AD and PD. In Paper I the expression profiles ...
49
Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?
... muscle dysfunction in uremia have been proposed, and oxidative stress could be ...muscle dysfunction in ...data. Oxidative stress can direct muscle cells into a catabolic state ...
7
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease.
... mitochondrial dysfunction and oxidative stress increase with the severity of chronic kidney ...mitochondrial dysfunction, measured by mtDNA copy number, lactate, or isofurans concentration, is ...
13
Mitochondrial dysfunction, oxidative stress, and neuroinflammation: Intertwined roads to neurodegeneration
... operates through the binding and activation of membrane or cytoplasmic pattern recognition receptors (PRRs) (reviewed in [30]). Indeed, mtDNA possesses hypomethylated CpG motifs that are similar to those of bacterial DNA ...
21
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
... of vasorelaxation and reduction of vasoconstriction on healthy MA, to the similar extent with MAT incubation from DbHET Flt3l-/- mice. However, this finding was different from previous result that MAT incubation from db ...
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