adoptive immunotherapy
Adoptive immunotherapy against ovarian cancer
... Cancer immunotherapy has recently emerged as a clinically effective tool in several solid tumors ...strategies, adoptive immunotherapy is considered one of the most promising ...options. ...
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Adoptive immunotherapy with liver allograft–derived lymphocytes induces anti HCV activity after liver transplantation in humans and humanized mice
... an adoptive immunotherapy approach, using lymphocytes extracted from liver allograft perfusate (termed herein liver allograft–derived lymphocytes), which includes an abundance of NK/NKT cells that mounted ...
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Is the CD4/CD8 Ratio an Effective Indicator for Clinical Estimation of Adoptive Immunotherapy for Cancer Treatment?
... lymphocyte immunotherapy at our institute, we cultured their cells ex vivo under stimu- lation with immobilized anti-CD3 antibody and IL-2 and analyzed them by flow cytometry using monoclonal an- tibodies against ...
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Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes
... Prostate cancer (PC) is the most commonly diagnosed malig- nancy and the second leading cause of cancer death in American men (1). Bone is the most common metastatic site for PC (2), and bone metastases are responsible ...
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Importance of cyclophosphamide induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice
... and adoptive immunotherapy in mice bearing four different syngeneic tumors (two responsive in vivo to CTX and two resistant); and (b) to define the mechanism(s) of the CTX-immunotherapy ...
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Adoptive immunotherapy with MUC1 mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer
... study, adoptive immunotherapy (AIT) with MUC1-DCs and MUC1-CTLs plus GEM resulted in a 1-year survival rate of greater than 50% in patients with unresectable or recurrent pancreatic invasive ductal ...
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Retargeted human avidin-CAR Tcells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging
... There has been significant progress in the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. However, the challenge of monitoring the therapy in real ...
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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
... Activated T cells lose expression of CD62L, a lymphoid homing molecule and key marker of highly potent T cell subsets for adoptive immunotherapy (5, 15, 44), in an AKT1/2-dependent man- ner (45). We ...
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Induction of Adult T-Cell Leukemia-Like Lymphoproliferative Disease and Its Inhibition by Adoptive Immunotherapy in T-Cell-Deficient Nude Rats Inoculated with Syngeneic Human T-Cell Leukemia Virus Type 1-Immortalized Cells
... 7 Induction of Adult T-Cell Leukemia-Like Lymphoproliferative Disease and Its Inhibition by Adoptive Immunotherapy in T-Cell-Deficient Nude Rats Inoculated with Syngeneic Human T-Cell Le[r] ...
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Immunophenotyping at the Time of Diagnosis Distinguishes Two Groups of Nasopharyngeal Carcinoma Patients: Implications for Adoptive Immunotherapy
... [18, 19] . In this study we have looked for immuno- logical parameters that may help to predict the effi- cacy of EBV-CTL adoptive immunotherapy. By im- munophenotyping of circulating lymphocytes from a ...
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BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models
... it increased memory precursors and reduced effector functions. Although BATF is required for efficient effector T cell functions in vivo, we found that suppression of BATF expression is advan- tageous during ex vivo ...
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Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.
... The current study was undertaken with the aim of targeting the kidney for allogeneic immune reactions, an organ that is not among the typical targets for graft-verus-host reactions; these usually include the ...
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<p>Application Of Adoptive Immunotherapy In Ovarian Cancer</p>
... restriction. Adoptive immunotherapy with TILs has a response rate of about 50% in melanoma ...cell adoptive therapy had a promising future in OC, although the experiment lacks ...TILs adoptive ...
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Adoptive Immunotherapy of Feline Immunodeficiency Virus with Autologous Ex Vivo-Stimulated Lymphoid Cells Modulates Virus and T-Cell Subsets in Blood
... of immunotherapy of lentiviral infections with au- tologous lymphoid cells restimulated and expanded ex ...41). Adoptive im- munotherapy has been exploited with some success to treat chronic viral ...
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Eradication of intractable malignant ascites by abdominocentesis, reinfusion of concentrated ascites, and adoptive immunotherapy with dendritic cells and activated killer cells in a patient with recurrent lung cancer: a case report
... Cytological examination was carried out before and after intraperitoneal immunotherapy. Before the treatment, ascites consisted exclusively of carcinoma cells varying in size with prominent nucleoli forming ...
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Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas permeable bag: interests for adoptive immunotherapy
... We report here the processing of a specific compart- mentalised bag into which TIL and feeder cells are inoculated in a restricted volume and that can accu- rately replace the standard system using multiple 96- well ...
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Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
... tive immunotherapy necessitates disruption of intercellular com- munication with T Mem cells, a finding with direct implications for the design and execution of ACT clinical ...
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Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy
... (79.1 ± 13.6% of untreated vs. 77.6 ± 14.9% of Akti-treated CD19CAR T cells) (Fig. 1d). Total cell growth was not compromised by inhibition of Akt signaling during 17 days of ex vivo expansion, which is the maximum days ...
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A short CD3/CD28 costimulation combined with IL 21 enhance the generation of human memory stem T cells for adoptive immunotherapy
... Background: Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor‑specific immune ...for adoptive T cell therapy of ...
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Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells
... A limiting factor of this study is the use of immuno- compromised mice lacking T cells that play a central role in tumor surveillance [37, 38]. It is well-known that NK cells, through release of cytokines, exchange ...
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