Adoptive T cell therapy
Adoptive T cell therapy for cancer in the clinic
... autologous T cells either 14 days or 100 days after transplant, and two doses of PCV beginning one month after ...Prompt T cell recovery was observed in patients that received ex vivo–expanded ...
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Adoptive T cell therapy: Addressing challenges in cancer immunotherapy
... for adoptive T cell therapy to become a clinically significant modality that participates in the standard treatment of patients with malignant ...gen-specific T cells is time and labor ...
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Endogenous T cells prevent tumor immune escape following adoptive T cell therapy
... of adoptive T cell therapy (ACT) is typically correlated with the functionality of the inoculated T cells, the role of the endogenous T cells is ...blockade therapy has ...
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Two photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
... that adoptive T cell therapy using in vitro primed CD8 + T cells induces tumor ...target cell occu- pied an individual CTL for an average of 6 ...+ T cell ...
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Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer
... anti-OX40 therapy, and peptide or DC ...in adoptive T cell therapy of cancer has not been fully ...effector T cells were generated in vitro by anti-CD3/anti-CD28 activation of ...
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Management of patients with non-Hodgkin’s lymphoma: focus on adoptive T-cell therapy
... Dovepress Adoptive T-cell therapy for NHL investigators have proposed transiently expressing CAR through electroporation of T-cells with in vitro-transcribed ribonucleic acid, 31 which ...
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OVERCOMING SAFETY AND EFFICACY CHALLENGES OF ADOPTIVE T-CELL THERAPY WITH CYTOKINE-CODING ONCOLYTIC ADENOVIRUSES
... enable adoptive T-cell therapy in metastatic solid ...adenovirus therapy in fostering the required immune stimulation to lift systemic immune anergy, aiming at facilitating different ...
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Original Article Mechanism and antitumor effect of combined treatment with gene modification in situ and adoptive T cell therapy in malignant melanoma
... with adoptive transfer of ESAT-6 specific T cells to tu- mor in ...and adoptive T cell therapy has great potential in melanoma therapy in ...
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Adoptive T cell therapy for the treatment of viral infections
... the adoptive transfer of in vitro expanded VSTs and since the mid-1990s we have undertaken a series of clinical trials using stem cell donor-derived T cell lines targeting one or more of these ...
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Exploiting the curative potential of adoptive T-cell therapy for cancer
... revealed recognition of a non-identical HLA-A2-restricted epitope present in MAGEA12. The combined analysis of real-time quantitative-polymerase chain reaction, NanoString quantitation, and deep-sequencing indicated that ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... CAR T cells as a therapeutic in the AML field, such as gene-editing technology, antibodies, and combination therapies, most of which have been presented in this ...expressing T cells in treating AML would ...
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The coming of age of adoptive T cell therapy for viral infection after stem cell transplantation
... donor-derived multi virus specific T cells were generated. Fourteen of the lines recognized all five of the component viral targets, while 35 (73%) recognized three or more viruses as determined by IFN-ELISpot ...
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Adoptive T-cell therapy improves treatment of canine non Hodgkin lymphoma post chemotherapy
... of T-cell numbers after chemotherapy has been previously noted to correlate with improved rates of malignant relapse and decreased mortality 23 .... Adoptive immunother- apy trials are underway in ...
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Pre-selection of PD-1+ Tumor-Infiltrating CD8+ T cells improves the efficacy of adoptive T-cell Therapy
... well cultures) of TILs from tumor fragments, or digested tumor cell suspensions, in the presence of high dose of IL-2. A total tumor lesion size of about 3 cm in diameter is required to successfully expand TILs. ...
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Adoptive T-Cell therapy as treatment for Epstein Barr virus-associated malignancies : strategies to enhance potential and broaden application
... LMP2-directed T-cell specificity will greatly enhance the potential application of immunotherapeutic strategies and our ability to evaluate their effect as treatment of EBV latency type II ...Cytotoxic ...
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Peters, Philipp (2018): T cell receptor modification by alpha and beta chain domain cross-over for adoptive T cell therapy. Dissertation, LMU München: Medizinische Fakultät
... mechanisms described in literature that combined could potentially explain our observations: First, there is a concept of native TCR “outcompeting” an introduced TCR for CD3 recruitment (Bethune et al. 2016). The idea is ...
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Higher Activities of Hepatic Versus Splenic CD8+ T Cells in Responses to Adoptive T Cell Therapy and Vaccination of B6 Mice with MHC Class-1 Binding Antigen
... of T cells 23 through expression of ...of T cells with the hypothesis that removal of these cells from the liver might induce negative impact on the retention of activated hepatic CD8 + T ...+ ...
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Principles of adoptive T cell cancer therapy
... to T cells ex vivo. The most appropri- ate methods of ex vivo T cell culture mimic the physiologic pro- cesses whereby DCs generate a constellation of antigen-specific and costimulatory signals in ...
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Adoptive T-cell transfer in cancer immunotherapy
... Summary Adoptive T-cell therapy has definite clinical benefit in relapsed leukaemia after allogeneic transplant and in Epstein–Barr virus-associated post-transplant lymphoproliferative ...
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Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice
... + T cells, and used them as adoptive T cell therapy (ACT) in combination with a PD-L1 blocking antibody in Rag1-deficient ...endogenous T cells that would be impacted by ...
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