Adoptive Transfer
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
... Anergic T cells generated ex vivo are reported to have immunosuppressive effects in vitro and in vivo. Here, we tested this concept in nonhuman primates. Alloreactive T cells were rendered anergic ex vivo by coculture ...
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Differentiation of C2D Macrophage Cells after Adoptive Transfer
... the adoptive transfer of C2D macrophage cells protected recipient immunocompromised mice from developing pneumonia after experimental challenge with Pasteurella pneumotropica ...successful adoptive ...
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Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells
... Figure 1 Treatment protocol and cell engraftment. Number of donor natural killer (NK) cells (A), γδ T cells (B), and αβ T cells (C) per microlitre. The individual symbols represent patient samples obtained at the ...
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Lymph node-derived donor encephalitogenic CD4+T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet
... The adoptive transfer model was developed to specifi- cally test the role of antigen specific T cells in EAE patho- genesis [5-7]. For this purpose, donor mice are immunized with antigen in CFA, and their ...
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Induction of degenerative brain lesions after adoptive transfer of brain lymphocytes from Borna disease virus-infected rats: presence of CD8+ T cells and perforin mRNA.
... a BDV-specific T-helper-cell line (23). This would also explain the delay of degenerative changes in the brain after transfer of in vitro-restimulated cervical lymph node and spleen cells. The data presented here, ...
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Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides
... macrophage transfer as a tool to delineate their pain-modulating properties, other re- searches have utilized this strategy as a therapy for ner- vous system disorders such as spinal cord injury [72, ...the ...
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Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option
... After the first demonstration of promising clinical ef- fects of TIL in melanoma patients in the 90’s and the be- ginning of the new millennium by the Surgery Branch of the National Institutes of Health (SB, NIH, ...
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Adoptive transfer of immunity to rabies virus
... Historical aspects Morphological description Factors affecting rabies viral infections Epidemiology Vaccines and treatments Nonspecific resistance to rabies Specific resistance to infect[r] ...
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Advances in siRNA delivery to T cells: potential clinical applications for inflammatory disease, cancer and infection
... trials currently evaluating the use of siRNAs for therapeutic purposes, progress in this area has been mixed and some of these trials have been terminated due to lack of a therapeutic benefit [180]. Furthermore, an siRNA ...
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Interleukin-4 causes delayed virus clearance in influenza virus-infected mice.
... the adoptive transfer experiment, we found that the treatment of sensitized cells with IL-4 during secondary in vitro stimulation resulted in lower concentrations of IFN- g in supernatant fluids (Table 1); ...
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Limited Type I Interferons and Plasmacytoid Dendritic Cells during Neonatal Respiratory Syncytial Virus Infection Permit Immunopathogenesis upon Reinfection
... or adoptive transfer of pDCs prior to neo- natal RSV infection reduced the pulmonary viral load during primary ...and adoptive transfer of FIG 5 Adoptive transfer of adult pDCs ...
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Sonic Hedgehog signaling limits atopic dermatitis via Gli2 driven immune regulation
... The proportion of IL-17+ cells in the skin CD4+ population was significantly reduced in the Gli2ΔN2 adoptive transfer group compared with the control group Supplemental Figure 5F, and th[r] ...
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Ulaganathan, Vijay Kumar (2010): Gene Expression Profiling of Encephalitogenic CD4+ T cells: Identification of Genes Controlling Migration of Effector T cells into the CNS. Dissertation, LMU München: Fakultät für Biologie
... Adoptive transfer EAE in Lewis rat is a monophasic disease which follows a highly predictable disease course. Intriguingly, the onset of the disease occurs only after an obligatory latency of at least 3 ...
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Stem cell–derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes
... Tregs are an important component of self-tolerance, and numerous studies have demonstrated the effects of Tregs on natural and induced autoimmune diseases in various mouse models (33, 34). Tar- geting Tregs as a ...
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Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice
... upon adoptive transfer of splenocytes from female donors, whereas female ...splenocyte transfer, indicates first that female splenocytes con- tain precursor cells capable of initiating infiltration ...
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Workshop on immunotherapy combinations Society for immunotherapy of cancer annual meeting Bethesda, November 3, 2011
... approach. In this disease there is a long interval from primary diagnosis to metastatic disease and serum PSA (doubling time velocity) can be used as a surrogate mar- ker for therapeutic response or disease recurrence. ...
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Cytokine induced killer cells promote antitumor immunity
... tumor effectively before releasing the virus and the modified vaccinia virus remains inactive until the CIK cell encounters with the tumor. These results highlight the idea that CIK cells can be used as a vehicle for ...
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Antiviral effect of lymphokine-activated killer cells: characterization of effector cells mediating prophylaxis.
... IFN protected targets from polyinosinic acid-polycytidylic acid-induced activated NK cells but enhanced their susceptibility to lysis by allospecific DISCUSSION The adoptive transfer stu[r] ...
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TGF β signaling is required for the function of insulin reactive T regulatory cells
... Signaling of TGF-β is important for the immune protection by 2H6 T cells. T cells from the 2H6 TCR transgenic mice showed sup- pressive properties and produced more TGF-β upon activation compared with those from the ...
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Protective Mechanisms Induced by a Japanese Encephalitis Virus DNA Vaccine: Requirement for Antibody but Not CD8+Cytotoxic T-Cell Responses
... used adoptive transfer experiments and gene knockout mice to demonstrate that the DNA-induced E-specific antibody alone can confer protection in the absence of cytotoxic T-lymphocyte (CTL) ...by ...
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