adult hippocampus
Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
... Figure 4 The number of proliferating type 1 and 2a cells was greater in the galectin-1-null mutant DG than the control DG. (A-A ’’’’ ) High-magnification images of Ki67 (blue), FABP7 (green), and DCX (red) triple ...
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GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors
... progenitors that generate proliferating neuroblasts, which exit the cell cycle before differentiating into granule neurons (Lugert et al., 2012). Neurogenesis is tightly regulated through a balance of NSC maintenance and ...
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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic and antidepressant like effects
... dorsal hippocampus was processed for BrdU immunohistochemistry, resulting in each section being 240 µm apart, thus ensuring the same cell would not be counted ...
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Sexual dimorphism in estrogen induced synaptogenesis in the adult hippocampus
... In the early nineties, it became evident that hormones, namely estrogens, influence synaptic plasticity. At that time, McEwen and co-workers discovered that ovariectomy results in loss of postsyn- aptic dendritic spines ...
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Frizzled-1 receptor regulates adult hippocampal neurogenesis
... the adult rat hippocampus, the Wnt/β-catenin signaling pathway is active in prolif- erating cells ...of adult-born neurons. Altogether, this evidence indicates that in the adult dentate gyrus ...
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Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
... New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell ...
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Neurogenic differentiation by hippocampal neural stem and progenitor cells is biased by NFIX expression
... Although our present study identifies neurogenic functions for Nfix in the adult hippocampus, we reveal two key differences with regards to its function within the embryonic brain. First, the relative ...
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Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development
... Several studies have suggested that the dosage of the Wnt and TGFβ/BMP pathways is critical and has to be tightly controlled through intricate networks of positive and nega- tive feedback loops [15, 19, 23, 32, 33]. It ...
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Amelioration of prenatal alcohol effects by environmental enrichment in a mouse model of FASD
... The effect of the environmental enrichment used has a subtle effect and relatively few genes (as analyzed by the microarray platform) in the adult hippocampus with most of the effects being significantly ...
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Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice
... the adult hippocampus, it could be that the qPCR approach is not sufficiently sensitive to detect very low levels of DNMT3a2 ...mature hippocampus (3 M) without the need for endogenous qPCR controls ...
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What is the functional role of adult neurogenesis in the hippocampus?
... The input layer represents the input patterns and does not perform any computation. The hidden layer performs an encoding and the output layer performs a decoding. Both layers are linear, and so is the whole network, ...
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MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above
... This study employed a Signa Horizon LX 1.0 Tesla MR unit (General Electric, Milwaukee, Wisconsin). The MR brain protocol series was performed first on sagittal T1 and on axial T1, T2 and fluid attenuation inversion ...
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The Behavioural Phenotype of pThr175-Tau Expression in the Hippocampus of Female Adult Sprague Dawley Rats
... the hippocampus have been demonstrated (Figure 2, Figure 3), and tau fibrillary structures have been identified in an experimental group (Thr175Asp-tau) at month 3 post-surgery (Figure ...the hippocampus ...
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Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry
... thalamus, hippocampus, frontal cortex, parietal cortex, occipital cortex, and amygdala, respec- tively ...in hippocampus, 14 in frontal cortex, 66 in parietal cor- tex, 24 in occipital cortex, and 36 in ...
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Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice
... Interleukin 1β (IL1β), interleukin 6 (IL6), tumor necrosis factor-α (TNF-α), interferon-inducible protein-10 (IP- 10) and toll-like receptor 4 (TLR4) mRNA levels were assessed in the hippocampus by quantitative ...
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Heat stress-induced memory impairment is associated with neuroinflammation in mice
... A number of studies showed that heat stress can cause cell death in the brain [6, 35, 36, 50]. Activated glial cells in the brain produce neurotoxic factors that subse- quently lead to neuronal death [44]. However, there ...
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Projection neurons in the cortex and hippocampus: differential effects of chronic khat and ethanol exposure in adult male rats
... young adult male rats markedly affects granular and pyramidal neurons, but in a different ...and hippocampus that are involved during chronic coadministration of khat and ...
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Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion
... to hippocampus-associated non-motor symptoms such as spatial learning and memory ...impaired adult hippocampal neurogenesis resulting from dopamine deficit and inflammation, represented in the ...
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Securitizing British India: A New Framework of Analysis for the First Anglo Afghan War
... and adult brain tumor survivors, shows that hippocampal abnormalities in adults should be predictive of impairments on both recall and recognition (encoding deficit ...
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Effects of Atorvastatin and Streptozocin on Immunohistochemical Markers in Hippocampus of Male Adult Rats
... the hippocampus significantly increases when the doses of 5 mg/kg, 10 mg/kg and 20 mg/kg atorvastatin orally are given after injection of 3 mg/kg streptozocin intrathecally compared with the group administered ...
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