AED resistance and the transporter hypothesis
Studies into the role of glucose transporter function in insulin resistance
... the hypothesis that a depletion in the intracellular GLUT4 transporter pool could account for the decreased insulin stimulated glucose uptake reported due to a lower number translocated to the cell ...
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Characterization of the Chloroquine Resistance Transporter Homologue in Toxoplasma gondii
... To elucidate the evolutionary relationships between CRT fam- ily proteins, we performed a phylogenetic analysis on CRT family proteins from apicomplexans, oomycetes, plants, red algae, and amoebae. This revealed that ...
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Survey of Plasmodium falciparum multidrug resistance 1 and chloroquine resistance transporter alleles in Haiti
... CQ resistance genotypes in Haiti are alarming for public health officials in Haiti and concerted efforts are needed to monitor the anti-malaria drug resistance genotypes in ...anti-malarial ...
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Chloroquine Resistance Modulated in Vitro by Expression Levels of the Plasmodium falciparum Chloroquine Resistance Transporter*
... To our knowledge, this is the first report in which genetic modification of a Plasmodium gene has been employed to spe- cifically study the effects of gene expression levels on drug- resistant phenotypes. Application of ...
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Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter
... ABSTRACT Overexpression of adenine triphosphate (ATP)-binding cassette (ABC) transporters is one of the main reasons of multidrug resistance (MDR) in cancer cells. Trametinib, a novel specific small-molecule ...
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Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance
... Defining the residues that interact with CQ and/or PPQ will enable us to predict novel mutations that could drive antimalarial resistance in geographically diverse PfCRT isoforms. As these mutations possibly ...
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Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
... drug resistance, such as remote symptomatic causes, early onset, multiple seizure types, and a high frequency of sei- zures before the initiation of treatment, provide a mechanistic explanation of the ...
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ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.
... adriamycin resistance and high ABCB1 expression was completely resistant to both CDK7i, whereas a mitoxantrone-resistant cell line with high ABCG2 expression, although non-responsive to THZ1, retained some ...
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Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum
... CQ resistance came from this region in the late 1950’s. MQ resistance was reported shortly after its deployment, a situation which was worsened despite doubling the drug dosage for ...
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In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene
... The present work demonstrated that piperaquine exhibits currently no cross-resistance with chloroquine in African P. falciparum isolates and that resistance to piperaquine is not associated with pfcrt , the ...
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Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes
... zinc transporter ZIP7 has suggested that this protein ameliorates ER-stress in heart muscle cells through ER-mediated zinc flux and therefore has a protective role against oxidative stress and ...
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Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell ...nucleoside ...
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Antibiotic resistance mediated by the MacB ABC transporter family : a structural and functional perspective
... ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative ...
18
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma
... ABC transporter genes in the human genome and their tendency for overlapping roles, and the fact that we wished to investigate early passage primary culture cells (which are challenging to transfect ...
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Association between acquired resistance to PLX4032 (vemurafenib) and ATP binding cassette transporter expression
... ABC transporter substrates including anti-cancer drugs and drugs that are administered for alternative indications ...ABC transporter-expressing cancer cells to co-administered anti-cancer drugs that are ...
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Role of Toxoplasma gondii Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance
... a Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA b Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy c Department of ...
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Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer
... pemetrexed resistance and can contribute to the optimization of breast cancer treatment ...ABC transporter family members in cell ...conferring resistance to pemetrexed in primary breast cancer cells ...
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RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer
... drug resistance is one of the major hurdles of mCRC treatment, and the underlying mechanisms are still largely ...the resistance against irinotecan and increases the sensitivity to other chemotherapeutic ...
11
Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence
... end of the abcB gene in the tagging construct. All the PCR products had a 40-bp overlap with the adjoining DNA fragments to generate the abcB- GFP-loxP-hph-loxP-abcB tagging construct in XbaI-linearized pRS316 by ...
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PACKAGES NON-ALCOHOLIC AED 260 VEGAN BRUNCH AED 350 HOUSE DRINKS AED 395 THE SOMMELIER CLUB AED 395 MOËT & CHANDON BRUT CHAMPAGNE AED 495
... Chocolate, Fresh & Marinated Fruits, Seasonal Cheesecake (D)(N)(V) فاديس.. BOCA’s Brunch is available Fridays from 01:00pm to 04:00pm Children 12 and under dine free with every payin[r] ...
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